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公开(公告)号：US10376490B2
公开(公告)日：2019-08-13
申请号：US15560578
申请日：2016-03-22
发明人： Naifeng Wu , Xijun Yan , He Sun , Kaijing Yan , Yonghong Zhu , Shunnan Zhang , Xiaolin Bai , Yi He , Xiaohui Ma , Ting Li
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K36/82 , A61K47/24 , B65D81/32 , A61K31/357
摘要： A pharmaceutical composition for treating non-alcoholic fatty liver diseases consists of a silybin-phospholipid complex preparation and Pu'er tea/tea product according to a weight ratio of 0.5-2.5:0.3-10, wherein the silybin-phospholipid complex capsule preparation and the Pu'er teat/tea product are separately packaged.
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公开(公告)号：US10307395B2
公开(公告)日：2019-06-04
申请号：US15560560
申请日：2016-03-22
发明人： He Sun , Xijun Yan , Naifeng Wu , Kaijing Yan , Yonghong Zhu , Shunnan Zhang , Xiaolin Bai , Xiaohui Ma , Yi He , Ting Li , Lei Li
IPC分类号： A61K36/00 , A61K31/357 , A61K36/82 , A61K47/24 , A61K9/48 , A61K31/205 , A61P1/16 , A61K9/16 , A61K31/355 , A61K31/683 , A61K9/08 , A61K36/488
摘要： A pharmaceutical composition for treating non-alcoholic fatty liver diseases. The pharmaceutical composition is prepared from 8.75-60 parts by weight of silybin, 15-65 parts by weight of phospholipid, 25-150 parts by weight of a Pu'er tea extract, and 10.425-60 parts by weight of L-carnitine.
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公开(公告)号：US09889093B2
公开(公告)日：2018-02-13
申请号：US14910173
申请日：2014-08-06
发明人： Henry Sun , Xiaohui Ma , Zhixin Guo , Sen Lin , Genbei Wang , Lulu Yan , Lihua Zhang , Shuiping Zhou , Shunnan Zhang
IPC分类号： A61K9/16 , A61K31/365 , A61K9/50 , B01J2/00
CPC分类号： A61K9/1682 , A61K9/1635 , A61K9/1676 , A61K9/5026 , A61K9/5078 , A61K31/365 , B01J2/006
摘要： The present invention relates to an andrographolide enteric targeting micropellet and a method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in preparation of a pharmaceutical for treatment of inflammatory bowel disease.
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公开(公告)号：USRE49035E1
公开(公告)日：2022-04-19
申请号：US16715485
申请日：2019-12-16
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Zhengliang Ye , Shunnan Zhang , Lihong Zhou , Wensheng Zhang , Hai'ou Dong
IPC分类号： A61K36/00 , A61K31/216 , A61K31/343 , A61K31/192 , A61K9/20 , A61K31/045 , A61K36/258 , A61K36/537 , A61K9/28 , A61K31/704 , A61K9/16 , A61K31/11 , A61K36/82
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
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公开(公告)号：US11013694B2
公开(公告)日：2021-05-25
申请号：US16422857
申请日：2019-05-24
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Xiaobing Sun , Shunnan Zhang , Zhengliang Ye , Hai'ou Dong , Hongbo Zhang , Wensheng Zhang , Lihong Zhou , Chenming Li , Cong Chen , Xiaofeng Liu , Shiqing Wang , Changsheng Rong , Yongfeng Zheng , Lijun Fan
IPC分类号： A61K9/20 , A61K36/537 , A61K36/258 , A61K45/06 , A61J3/06 , A61K9/50 , A61K36/48 , A61K36/481
摘要： The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
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公开(公告)号：US10300030B2
公开(公告)日：2019-05-28
申请号：US14910088
申请日：2014-08-28
发明人： Xijun Yan , Naifeng Wu , Shunnan Zhang , Ping Li , Zhengliang Ye , Lihong Zhou , Lianwen Qi , Fenglian Zhang , Minchao Qi , Zhexuan Yang , Wei Sun , Jing Yu , Hua Yang , Peng Liu , Xiaohui Ma , Hai'ou Dong , Wensheng Zhang , Lanlan Zhang , Chenming Li
IPC分类号： A61K31/192 , A61K31/704 , A61K36/537 , A61K31/7028 , A61K31/11 , A61K31/216 , A61K31/343 , A61K31/352 , A61K36/258
摘要： A traditional Chinese medicine composition and preparation thereof for treating cardiovascular diseases is provided. The traditional Chinese medicine composition consists of: by weight percentage, phenolic acid derivatives 30%˜80%, tanshinones 2%˜10% and saponins 15%˜60%.
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公开(公告)号：US09999630B2
公开(公告)日：2018-06-19
申请号：US14903995
申请日：2014-07-11
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Zhengliang Ye , Shunnan Zhang , Lihong Zhou , Wensheng Zhang , Hai'ou Dong
IPC分类号： A61K36/00 , A61K31/704 , A61K36/537 , A61K36/258 , A61K31/045 , A61K9/20 , A61K31/192 , A61K31/216 , A61K31/343 , A61K9/28
CPC分类号： A61K31/704 , A61K9/16 , A61K9/1664 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2059 , A61K9/2068 , A61K9/2893 , A61K31/045 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/343 , A61K36/258 , A61K36/537 , A61K36/82 , A61K2300/00
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
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8.发明申请公开(公告)号：US20160175336A1
公开(公告)日：2016-06-23
申请号：US14903995
申请日：2014-07-11
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Zhengliang Ye , Shunnan Zhang , Lihong Zhou , Wensheng Zhang , Hai'ou Dong
IPC分类号： A61K31/704 , A61K36/258 , A61K31/045 , A61K9/28 , A61K31/192 , A61K31/216 , A61K31/343 , A61K36/537 , A61K9/20
CPC分类号： A61K31/704 , A61K9/16 , A61K9/1664 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2059 , A61K9/2068 , A61K9/2893 , A61K31/045 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/343 , A61K36/258 , A61K36/537 , A61K36/82 , A61K2300/00
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
摘要翻译： 一种治疗心血管疾病的中药组合物及其制备方法，特别是其微滴丸制剂及其制备方法。 制备微滴丸制剂的方法可用于制备具有高药物负载能力的滴丸，包衣药丸和滴丸胶囊。
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公开(公告)号：US11318112B2
公开(公告)日：2022-05-03
申请号：US15560573
申请日：2016-03-22
发明人： He Sun , Xijun Yan , Naifeng Wu , Kaijing Yan , Yonghong Zhu , Shunnan Zhang , Xiaolin Bai , Xiaohui Ma , Yi He , Ting Li , Lei Li
IPC分类号： A61K31/357 , A61K36/82 , A61K47/24 , A61K9/48 , A61K31/205 , A61P1/16 , A61K9/16 , A61K31/355 , A61K31/683 , A61K9/08 , A61K36/488
摘要： A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
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公开(公告)号：US10507197B2
公开(公告)日：2019-12-17
申请号：US15560576
申请日：2016-03-22
发明人： Naifeng Wu , Xijun Yan , He Sun , Kaijing Yan , Yonghong Zhu , Shunnan Zhang , Xiaolin Bai , Yi He , Xiaohui Ma , Ting Li , Lei Li
IPC分类号： A61K31/357 , A61K36/82 , A61K47/24 , A61K9/48 , A61K31/205 , A61P1/16 , A61K9/16 , A61K31/355 , A61K31/683 , A61K9/08 , A61K36/488
摘要： Disclosed is a pharmaceutical composition containing silibinin, which is prepared from the following bulk drugs by weight ratio: 8.75-60 parts of silibinin, 15-65 parts of phospholipid, and 25-200 parts of Pu'er tea extract. The drug has the function of treating non-alcoholic fatty liver.
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