公开(公告)号：US10273288B2

公开(公告)日：2019-04-30

申请号：US16190676

申请日：2018-11-14

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America, as represented by the Secretary of the Army ,  Humabs BioMed SA

Inventor： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  G01N33/569

Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US10058602B2

公开(公告)日：2018-08-28

申请号：US14305572

申请日：2014-06-16

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The United States of America, as Represented by The Secretary of The Army

Inventor： Alexander G. Pletnev ,  Joseph R. Putnak ,  Robert M. Chanock ,  Brian R. Murphy ,  Stephen S. Whitehead ,  Joseph E. Blaney

IPC: A61K45/06 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005 ,  C12N15/86 ,  C12Q1/6888 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24162 ,  C12Q1/6888 ,  Y02A50/386 ,  Y02A50/394

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

公开(公告)号：US09427476B2

公开(公告)日：2016-08-30

申请号：US14402988

申请日：2013-05-23

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The United States of America, as Represented by the Secretary of the Army

Inventor： Che-Hung Robert Lee ,  Valerian B. Pinto

IPC: A61K39/095 ,  A61K47/48 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K47/646 ,  A61K2039/572 ,  A61K2039/70 ,  Y02A50/484

Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.

Abstract translation: 本文公开了脑膜炎球菌免疫原性缀合物，其可以引发针对组A，C，W-135和Y以及B组因子H结合蛋白（fHbp）的脑膜炎球菌多糖（PS）的免疫应答。 所公开的缀合物还表现出对脑膜炎球菌A，C，W-135，Y，B和X血清群的杀菌活性。 还公开了用于制备缀合物（例如免疫原性缀合物）的改进方法，包括在约4℃下用氰化剂活化多糖。

公开(公告)号：US10537337B2

公开(公告)日：2020-01-21

申请号：US15100258

申请日：2014-11-25

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  The United States of America; As represented by the Secretary of Defence, Walter Reed National Military Medical Center ,  The United States of America; as Represented by the Secretary of the Navy, IP Counsel of the Navy Office of Naval Research

Inventor： Chad Gordon ,  Mehran Armand ,  Ryan Murphy ,  Gerald Grant ,  Peter Liacouras ,  Kevin Wolfe

IPC: A61B34/10 ,  G06F19/00 ,  A61B17/17 ,  A61B17/15 ,  G16H50/50 ,  A61B34/20 ,  A61B17/16 ,  A61B17/80 ,  A61F2/28

Abstract: A computer-assisted surgical system can include a donor sub-system and a recipient sub-system. The donor sub-system includes a first reference unit having a first trackable element, a fragment reference unit having a second trackable element, and a first detector configured to provide at least one of a first signal corresponding to a detected location of one or more of the first trackable element and the second trackable element. The recipient sub-system includes a second reference unit having a third trackable element, and a second detector configured to provide at least one of a second signal corresponding to a detected location of at least the third trackable element.

公开(公告)号：US10160795B2

公开(公告)日：2018-12-25

申请号：US15526661

申请日：2015-11-13

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America as represented by the Secretary of the Army ,  Humabs BioMed SA

Inventor： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/00 ,  G01N33/569

Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US20180346553A1

公开(公告)日：2018-12-06

申请号：US16048389

申请日：2018-07-30

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE ,  The Government of the United States of America, as Represented by the Secretary of Homeland Security

Inventor： ALFONSO CLAVIJO ,  AIDA ELIZABETH RIEDER ,  ABU SAYED ,  MANGKEY A. BOUNPHENG ,  THOMAS G. BURRAGE ,  BROOKE A. DANCHO ,  SABENA UDDOWLA BLAKENEY

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/1009 ,  C07K2317/34 ,  C07K2319/21 ,  C12N2770/32122 ,  C12N2770/32134 ,  G01N33/56983 ,  G01N2333/09

Abstract: This disclosure pertains to isolated antibodies or antigen binding fragments thereof that specifically bind to the 3ABC non-structural protein of Foot-and-Mouth Disease virus (FMDV), wherein the antibodies or antigen binding fragments thereof recognize the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 or SEQ ID NO: 12. Accordingly, this disclosure also pertains to polypeptides having an amino acid sequence selected from SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 or SEQ ID NO: 12. Monoclonal antibody Mab 40C8 is also provided. The current disclosure also pertains to methods of detecting FMDV infection in an animal (including assays differentiating infected animals from vaccinated animals (DIVA)) and kits for performing the detection methods. Competitive ELISA kits comprising the antibody or antigen binding fragment thereof and immunoassay plates coated with the polypeptide comprising the amino acid sequence selected from SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 and/or SEQ ID NO: 12 are also provided.

公开(公告)号：US10448956B2

公开(公告)日：2019-10-22

申请号：US15100215

申请日：2014-11-26

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF DEFENSE

Inventor： Chad Gordon ,  Mehran Armand ,  Ryan Murphy ,  Gerald Grant ,  Peter Liacouras ,  Kevin Wolfe ,  Ehsan Basafa

IPC: A61B5/02 ,  A61B17/15 ,  G16H50/50 ,  A61B17/17 ,  A61B34/10 ,  A61B34/20 ,  A61B17/16 ,  A61B17/80 ,  A61F2/28 ,  G06F19/00

Abstract: A method for computer-assisted planning of a transplant surgery is provided. The method includes obtaining a computer-readable representation of a donor and recipient skeletal fragment; determining surgical cutting planes on the computer-readable representation of the donor skeletal fragment from which a portion of the donor skeletal fragment from the computer-readable representation of the donor skeletal fragment will be harvested; determining virtual cutting guides; performing a virtual osteotomy to separate the portion of the donor skeletal fragment from the computer-readable representation of the donor skeletal fragment from a remainder portion of the donor skeletal fragment based on a position of the virtual cutting guides that are attached to the computer-readable representation of the donor skeletal fragment; positioning the donor skeletal fragment within a transplant region of the recipient skeletal fragment; and creating a hybrid computer-readable representation comprising the recipient skeletal fragment and the portion of the donor skeletal.

公开(公告)号：US20220034884A1

公开(公告)日：2022-02-03

申请号：US17389645

申请日：2021-07-30

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy ,  The Government of the United States of America, as represented by the Secretary, Department of Healt

Inventor： Eunkeu Oh ,  Kimihiro Susumu ,  Mason A. Wolak ,  Kirill Gorshkov

IPC: G01N33/569 ,  G01N33/58

Abstract: Quantum dots conjugated to SARS-CoV-2 Spike protein receptor binding domain (RBD) interact with gold nanoparticles bound to angiotensin converting enzyme 2 (ACE2) and thus undergo energy transfer. This energy transfer indicates RBD/ACE binding and can be used to assay for inhibitors thereof. Moreover, these labeled quantum dots were found to undergo endocytosis in cells expressing ACE2.

公开(公告)号：US10351850B2

公开(公告)日：2019-07-16

申请号：US15709890

申请日：2017-09-20

Applicant: The United States of America as represented by the Secretary of the Navy ,  The United States of America as represented by the Secretary of Agriculture

Inventor： Alden S. Estep, III ,  James J. Becnel ,  Neil D. Sanscrainte

IPC: C12N15/113 ,  A01N25/00 ,  A01N63/00

Abstract: A composition for use in formulations for controlling insect populations, including populations of mosquito and flies. The composition comprises one or more double-stranded constructs inhibitory to RNA transcription of ribosomal proteins. The invention also relates to method of using the compositions in formulations to inhibit insect populations.

公开(公告)号：US20250156981A1

公开(公告)日：2025-05-15

申请号：US18937200

申请日：2024-11-05

Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security

Inventor： Matthew R. Aderholdt ,  Lee J. Spanier

IPC: G06Q50/26 ,  G01G19/44 ,  G06V20/52

Abstract: In an example, a monitoring method for screening an individual, the monitoring method comprising: performing a pre-checkpoint monitoring of a stance of the individual as the individual's stance to collect baseline data including weight distribution and balance of the individual as the individual's weight distribution and balance; performing a pre-scanning monitoring of the individual's stance at a scanning system at a checkpoint to collect pre-scanning monitoring data prior to scanning the individual by the scanning system; and comparing the pre-scanning monitoring data with the baseline data to determine whether the pre-scanning monitoring data falls below a pre-scanning threshold with respect to the baseline data, the individual resetting the individual's stance at the scanning system until the pre-scanning monitoring data is below the pre-scanning threshold with respect to the baseline data before scanning the individual at the scanning system.