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13 条记录 (耗时 0.016 秒)

    HBV treatment
    2.
    发明授权
    HBV treatment 有权
    HBV治疗

    公开(公告)号：US09080174B2

    公开(公告)日：2015-07-14

    申请号：US13882124

    申请日：2011-10-27

    申请人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    发明人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    IPC分类号： C07H21/04 ,  C12N15/113

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/531

    摘要： RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.

    摘要翻译： 提供RNA干扰（RNAi）试剂和使用RNAi试剂治疗个体中的乙型肝炎感染，以及含有RNAi试剂的药物组合物。 用于表达它们的RNAi剂或构建体用于抑制至少一种乙型肝炎病毒（HBV）基因的表达，其中每种试剂包含与从靶区转录的预测序列互补或基本上互补的效应序列。 在本发明的一些实施方案中，所述试剂具有多于一个效应序列; 其中所述多个效应子可以靶向相同基因和/或不同HBV基因的HBV基因的相同区域，不同（可能重叠的）区域。

    Multi-targets interfering RNA molecules and their applications
    5.
    发明授权
    Multi-targets interfering RNA molecules and their applications 有权
    多靶点干扰RNA分子及其应用

    公开(公告)号：US09115167B2

    公开(公告)日：2015-08-25

    申请号：US13415600

    申请日：2012-03-08

    申请人： York YuanYuan Zhu ,  TieJun Li

    发明人： York YuanYuan Zhu ,  TieJun Li

    IPC分类号： C07H21/02 ,  A61K31/7088

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/52 ,  C12N2310/53 ,  C12N2310/531

    摘要： This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.

    摘要翻译： 本发明涉及干扰RNA（iRNA）分子及其应用，特别是多靶标iRNA分子及其应用。 所述多靶iRNA分子由在至少一条反义链上退火的有义链组成，每条链长度至少为30个核苷酸，正义或反义链具有至少两个片段，其可靶向至少两个不同的RNA 基因，或可靶向RNA的至少两部分，并且其中iRNA在转染入细胞时不诱导干扰素反应。 iRNA分子可以干扰转录后的翻译过程，靶基因被抑制或阻断，iRNA在体内不诱导干扰素反应。 RNA分子是可以调节一种或多种基因功能的药物的制备中的活性成分。

    Protective jewelry display device
    6.
    发明申请
    Protective jewelry display device 审中-公开
    防护饰品显示装置

    公开(公告)号：US20150027910A1

    公开(公告)日：2015-01-29

    申请号：US14065885

    申请日：2013-10-29

    申请人： Tiejun LI

    发明人： Tiejun LI

    IPC分类号： A45C11/16

    CPC分类号： A45C11/16 ,  A45C2200/10

    摘要： A protective display device comprising a hollow transparent tube; an article for sale or display placed inside the tube; two covers respectively closing openings at both ends of the tube; a disposable blocking material closing and locking connecting portions between each end of the tubes and each of the two covers; at least one observation window passing through walls of the tube to facilitate measurement and observation of the article for sale or display.

    摘要翻译： 一种保护性显示装置，包括中空透明管; 出售或放置在管内的物品; 两个盖分别在管的两端封闭开口; 一次性阻塞材料封闭和锁定管的每个端部和两个盖中的每一个之间的连接部分; 至少一个观察窗通过管的壁，以便于用于销售或展示的物品的测量和观察。

    Large-field unit-magnification projection optical system
    7.
    发明授权
    Large-field unit-magnification projection optical system 有权
    大场单位放大投影光学系统

    公开(公告)号：US07746571B2

    公开(公告)日：2010-06-29

    申请号：US12302824

    申请日：2006-12-04

    申请人： Tiejun Li ,  Ling Huang ,  Jun Wei

    发明人： Tiejun Li ,  Ling Huang ,  Jun Wei

    IPC分类号： G02B9/60 ,  G02B17/00

    CPC分类号： G02B17/08 ,  G02B13/26 ,  G03F7/70225 ,  G03F7/70791

    摘要： The present invention discloses a large-field unit-magnification projection optical system. The optical system includes an optical axis, a spherical concave reflection mirror; a lens group with positive refracting power arranged adjacent the mirror with an air space therebetween. The lens group includes a first plano-convex lens, a negative meniscus lens adjacent the plano-convex lens, a positive lens adjacent the negative meniscus lens, a negative double-convex lens spaced apart far from the positive lens, and a second plano-convex lens. The optical system further includes a pair of prisms each having respective first and second surface. The second surfaces are arranged adjacent the flat surface of the plano-convex lens element on opposite sides of the optical axis and the first surfaces are arranged adjacent object planes and image planes, respectively. Each lens in the lens group and the pair of prisms provide chromatic aberration correction in a spectral region that contains at least g, h and i-line wavelengths. In this projection optical system, the object plane is parallel to the image plane.

    摘要翻译： 本发明公开了一种大视场单位放大投影光学系统。 光学系统包括光轴，球面凹面反射镜; 具有正反射功率的透镜组，其布置在反射镜附近，其间具有空气空间。 透镜组包括第一平凸透镜，与平凸透镜相邻的负弯月透镜，邻近负弯月透镜的正透镜，与正透镜间隔开的负双凸透镜，以及第二平凸透镜， 凸透镜 光学系统还包括一对棱镜，每个棱镜具有相应的第一和第二表面。 第二面与光轴的相对侧的平凸透镜元件的平面相邻配置，第一面与物平面和像面分别配置。 透镜组中的每个透镜和一对棱镜在包含至少g，h和i线波长的光谱区域中提供色差校正。 在该投影光学系统中，物平面与图像平面平行。