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24 条记录 (耗时 0.029 秒)

    Antiarrhythmic agent
    2.
    发明授权
    Antiarrhythmic agent 失效
    抗心律失常药

    公开(公告)号：US5654317A

    公开(公告)日：1997-08-05

    申请号：US403891

    申请日：1995-03-17

    申请人： Takafumi Fujioka ,  Shuji Teramoto ,  Michiaki Tominaga ,  Yoichi Yabuuchi

    发明人： Takafumi Fujioka ,  Shuji Teramoto ,  Michiaki Tominaga ,  Yoichi Yabuuchi

    IPC分类号： A61K31/47 ,  A61K31/4704

    CPC分类号： A61K31/4704 ,  A61K31/47

    摘要： An antiarrhythmic agent which comprises as an active ingredient a carbostyril derivative of the formula: ##STR1## wherein R.sub.1 is hydrogen atom or a lower alkyl group, and R.sub.2 is a phenyl-lower alkyl group which has optionally 1 to 3 substituents of a lower alkoxy group on the phenyl ring, or a pharmaceutically acceptable salt thereof.

    摘要翻译： PCT No.PCT / JP93 / 01294 Sec。 371日期1995年3月17日 102（e）1995年3月17日PCT 1993年9月10日PCT公布。 出版物WO94 / 06427 日期：1994年3月31日一种抗心律失常药，其包含下式的喹诺酮衍生物作为活性成分：其中R1是氢原子或低级烷基，R2是具有任选的苯基 - 低级烷基 苯基环上1至3个低级烷氧基的取代基，或其药学上可接受的盐。

    Agent for treating thrombosis and phosphodiesterase inhibitor
    3.
    发明授权
    Agent for treating thrombosis and phosphodiesterase inhibitor 失效
    治疗血栓形成和磷酸二酯酶抑制剂的药剂

    公开(公告)号：US5401754A

    公开(公告)日：1995-03-28

    申请号：US208803

    申请日：1994-03-11

    申请人： Takafumi Fujioka ,  Shuji Teramoto ,  Michiaki Tominaga ,  Yoichi Yabuuchi

    发明人： Takafumi Fujioka ,  Shuji Teramoto ,  Michiaki Tominaga ,  Yoichi Yabuuchi

    IPC分类号： A61K31/47 ,  A61P7/02 ,  A61P43/00 ,  C07D215/22 ,  C07D215/227

    CPC分类号： C07D215/227 ,  A61K31/47

    摘要： A pharmaceutical preparation comprising at least one compound selected from the group consisting of carbostyril derivatives having the general formula: ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group optionally having hydroxy group as a substituent; R.sup.2 is a phenyl(lower alkyl) group optionally having 1 to 3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring, pyridyl(lower alkyl) group, or a group of the formula --A--NR.sup.3 R.sup.4 (wherein A is a lower alkylene group, R.sup.3 and R.sup.4 are the same or different and represent a lower alkyl group or phenyl group), and a salt thereof, which is useful as an agent for treating thrombosis, more particularly, as an agent for inhibiting platelet aggregation and as an agent for platelet aggregate dissociation.

    摘要翻译： 一种药物制剂，其包含至少一种选自具有以下通式的喹诺酮衍生物的化合物：其中R 1为氢或任选具有羟基作为取代基的低级烷基; R2是任选具有1〜3个选自苯环上的低级烷氧基和卤素原子的取代基的苯基（低级烷基），吡啶基（低级烷基）或式-A- NR3R4（其中A为低级亚烷基，R3和R4相同或不同，表示低级烷基或苯基）及其盐，其可用作治疗血栓形成的药剂，更特别是作为药剂 用于抑制血小板聚集和作为血小板聚集体解离的药剂。

    Carbostyril derivatives and antihistaminic agents containing the carbostyril derivatives
    5.
    发明授权
    Carbostyril derivatives and antihistaminic agents containing the carbostyril derivatives 失效

    公开(公告)号：US4567187A

    公开(公告)日：1986-01-28

    申请号：US366336

    申请日：1982-04-07

    申请人： Kazuo Banno ,  Takafumi Fujioka ,  Masaaki Osaki ,  Kazuyuki Nakagawa

    发明人： Kazuo Banno ,  Takafumi Fujioka ,  Masaaki Osaki ,  Kazuyuki Nakagawa

    IPC分类号： C07D241/02 ,  C07D215/22 ,  C07D215/227 ,  C07D295/04 ,  A61K31/47

    CPC分类号： C07D215/227

    摘要： Novel carbostyril derivatives and their salts having antihistaminic effect and central nervous system controlling effect and are useful as antihistaminic agents and central nervous system controlling agents, represented by the general formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group, a lower alkenyl group, a lower alkynyl group; A is a group of the formula ##STR2## or a group of the formula ##STR3## (wherein R.sup.2 is a hydrogen atom or a lower alkyl group); B is a lower alkylene group; l is 1 when A is a group of the formula ##STR4## or l is 0 or 1 when A is a group of the formula ##STR5## Z is a group of the formula ##STR6## (wherein R.sup.3 is a substituted-phenyl group having 1 to 3 substituents, on the phenyl ring, selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkoxy-carbonyl group, a carboxyl group, a lower alkylthio group, a lower alkanoyl group, a hydroxyl group, a nitro group, an amino group and a cyano group; or R.sup.3 is a substituted-phenyl group having a lower alkylenedioxy group as the substituent, a phenyl-lower alkyl group or a 1,2,3,4-tetrahydronaphthyl group; R.sup.4 is a substituted-phenyl group having 1 to 3 substituents, on the phenyl group, selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; or R.sup.4 is a substituted-phenyl group having a lower alkylenedioxy group as the substituent, a phenyl-lower alkyl group, a 1,2,3,4-tetrahydronaphthyl group or a group of the formula ##STR7## R.sup.5 is a hydrogen atom, a hydroxyl group or a lower alkanoyl group; or when R.sup.5 is a hydrogen atom the carbon-carbon bond between 3- and 4-positions in the piperidine ring is a double bond which is dehydrogenated the hydrogen atoms bonded at 3- and 4-positions of piperidine ring; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or double bond.The carbostyril derivatives of the present invention have antihistaminic effects and central nervous system controlling effects and are useful for antihistaminic agents and central nervous system controlling agents.

    Carbostyril derivatives and pharmaceutical composition containing the same
    6.
    发明授权
    Carbostyril derivatives and pharmaceutical composition containing the same 失效
    碳青霉烯衍生物和含有其的药物组合物

    公开(公告)号：US4455422A

    公开(公告)日：1984-06-19

    申请号：US366335

    申请日：1982-04-07

    申请人： Kazuo Banno ,  Takafumi Fujioka ,  Masaaki Osaki ,  Kazuyuki Nakagawa

    发明人： Kazuo Banno ,  Takafumi Fujioka ,  Masaaki Osaki ,  Kazuyuki Nakagawa

    IPC分类号： C07D241/02 ,  C07D215/22 ,  C07D215/227 ,  C07D295/04 ,  C07D401/00 ,  A61K31/495

    CPC分类号： C07D215/227

    摘要： Novel carbostyril derivatives and their salts, having antihistaminic effect and central nervous system controlling effect, are represented by the general formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group, a lower alkenyl group, a lower alkynyl group; A is a group of the formula ##STR2## (wherein R.sup.2 is a hydrogen atom or a lower alkyl group); B is a lower alkylene group; l is 1 when A is a group of the formula ##STR3## or l is 0 or 1 when A is a group of the formula ##STR4## Z is a group of the formula >N--R.sup.3 or ##STR5## (wherein R.sup.3, R.sup.4 and R.sup.5 are as defined herein).

    摘要翻译： 具有抗组胺作用和中枢神经系统控制作用的新型喹诺酮衍生物及其盐由通式（1），其中R 1为氢原子，低级烷基，苯基 - 低级烷基 基，低级烯基，低级炔基; A是下式的基团：其中R 2是氢原子或低级烷基; B是低级亚烷基; 当A是下式的组时，A是式（IMAGE）的组或l是0或1，当A是下式的基团时，Z是1，其中Z是式> N-R3或的基团（其中R3， R4和R5如本文所定义）。