-
公开(公告)号：US4346095A
公开(公告)日：1982-08-24
申请号：US64072
申请日：1979-08-06
Applicant: James B. Mercer
Inventor： James B. Mercer
IPC: A61K31/415
CPC classification number: A61K31/415 , Y10S514/863 , Y10S514/894 , Y10S514/896
Abstract: The administration internally to humans of 1-(B-hydroxethyl)-2-methyl-5-nitromidazole, (metronidazole) in a dosage range for adult humans of about 31 to 2,500 mgs per twenty-four hour period, is an effective therapeutic treatment for certain viral infections causing diverse symptoms both acute and chronic. Corresponding dosage proportional to body weight appears effective in other mammals also.
Abstract translation: 对于成人的剂量范围内，每二十四小时内给予1-（B-羟基乙基）-2-甲基-5-硝唑唑（甲硝唑）向人类内给药是一种有效的治疗方法 某些病毒感染引起急性和慢性各种症状。 与体重成正比的相应剂量也可见于其他哺乳动物。
-
公开(公告)号：US5707992A
公开(公告)日：1998-01-13
申请号：US418415
申请日：1995-04-07
Applicant: Stephen E. Webber , Ted M. Bleckman , John Attard , Terence R. Jones , Michael D. Varney
Inventor： Stephen E. Webber , Ted M. Bleckman , John Attard , Terence R. Jones , Michael D. Varney
IPC: A61K31/505 , A61K31/517 , A61P31/04 , A61P31/10 , A61P35/00 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/93 , C07D239/95 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/12
CPC classification number: C07D401/12 , C07D239/90 , C07D239/93 , C07D239/95 , C07D403/06 , C07D403/12 , C07D417/12 , Y10S514/895 , Y10S514/896 , Y10S514/898
Abstract: Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
-
公开(公告)号：US5585365A
公开(公告)日：1996-12-17
申请号：US273095
申请日：1994-07-08
Applicant: Toshimitsu Hayashi , Kyoko Hayashi , Ichiro Kojima
Inventor： Toshimitsu Hayashi , Kyoko Hayashi , Ichiro Kojima
IPC: A01N43/04 , A01N63/02 , A23G1/00 , A23G1/56 , A23G3/00 , A23K1/16 , A23L1/0532 , A23L1/223 , A23L1/30 , A23L1/48 , A23L2/52 , A61K31/715 , A61K35/74 , A61P31/12 , A61P31/16 , C08B37/00 , A01N61/00 , A61K39/12
CPC classification number: A61K35/748 , A01N43/16 , A01N63/02 , A23G1/56 , A23K20/163 , A23L2/52 , A23L27/14 , A23L29/256 , A23G2200/06 , Y10S514/885 , Y10S514/888 , Y10S514/896 , Y10S514/934
Abstract: An antiviral polysaccharide purified from an extract prepared by extracting Spirulina cells with hot water, having the following properties:(1) it comprises rhamnose, glucose, fructose, ribose, galactose, xylose, mannose, glucuronic acid and galacturonic acid;(2) it exhibits an absorption at 480 nm in phenolsulfuric acid reaction; and(3) it has a molecular weight of 250,000 to 300,000 Daltons as determined by gel filtration; and pharmaceuticals, food and feed, comprising said antiviral polysaccharide.
Abstract translation: 从通过用热水提取螺旋藻细胞制备的提取物中纯化的抗病毒多糖，具有以下性质：（1）它包含鼠李糖，葡萄糖，果糖，核糖，半乳糖，木糖，甘露糖，葡糖醛酸和半乳糖醛酸; （2）在苯酚硫酸反应中，其在480nm处表现出吸收; 和（3）通过凝胶过滤测定其分子量为250,000至300,000道尔顿; 以及包含所述抗病毒多糖的药物，食品和饲料。
-
公开(公告)号：US5001119A
公开(公告)日：1991-03-19
申请号：US126215
申请日：1987-11-25
Applicant: Arthur G. Schwartz , Marvin L. Lewbart
Inventor： Arthur G. Schwartz , Marvin L. Lewbart
IPC: C07J1/00 , C07J11/00 , C07J13/00 , C07J21/00 , C07J41/00 , C07J43/00 , C07J51/00 , C07J53/00 , C07J71/00
CPC classification number: C07J51/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J11/00 , C07J13/005 , C07J21/00 , C07J21/008 , C07J41/0005 , C07J41/0038 , C07J43/003 , C07J53/001 , C07J53/004 , C07J71/001 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/888 , Y10S514/889 , Y10S514/894 , Y10S514/896 , Y10S514/897 , Y10S514/903 , Y10S514/908 , Y10S514/934
Abstract: Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.
Abstract translation: 下式的化合物可用作抗癌，抗肥胖，抗糖尿病，抗冠状动脉剂，抗衰老剂，抗降血脂药和抗自身免疫剂。
-
公开(公告)号：US4657761A
公开(公告)日：1987-04-14
申请号：US741344
申请日：1985-06-05
Applicant: Cesar M. Pinto
Inventor： Cesar M. Pinto
IPC: A61K39/295 , A61K39/00
CPC classification number: A61K39/12 , A61K39/04 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/35 , A61K39/38 , A61K2039/58 , A61K2039/70 , C12N2760/18734 , C12N2760/20134 , Y10S514/825 , Y10S514/859 , Y10S514/863 , Y10S514/885 , Y10S514/894 , Y10S514/896 , Y10S514/903 , Y10S514/931 , Y10S514/934
Abstract: A non-specific therapeutic polyvalent vaccine for subcutaneous injection containing a minimum combination of a PPD (tuberculin vaccine), a rabies vaccine, and snake venom vaccine and preferably including at least a DTP vaccine in addition and optimally a mumps antigen vaccine and Dermatophytin vaccine in controlled levels, all such constituent vaccines being commercially available. The vaccine provides a broad-based stimulation or potentiation of the immuno-defense system of the patient and is useful for the symptomatic relief and/or mitigation of diseases of viral origin, such as Herpes Zoster, labialis and genitalis, various neuralgias, mumps, measles, viral hepatitis, psoriasis and severe acne, or of autoimmune origin, such as multiple sclerosis and arthritis.
Abstract translation: 一种用于皮下注射的非特异性治疗性多价疫苗，其包含PPD（结核菌素疫苗），狂犬病疫苗和蛇毒疫苗的最小组合，并且优选地还包括至少一种DTP疫苗，并且最佳地包含腮腺炎抗原疫苗和Dermatophytin疫苗 所有这些成分疫苗都是可商购的。 疫苗提供广泛的刺激或增强患者的免疫防御系统，并且可用于病毒源性疾病的症状缓解和/或缓解，例如带状疱疹，唇唇和生殖器，各种神经痛，腮腺炎， 麻疹，病毒性肝炎，牛皮癣和严重痤疮，或自身免疫性起源，如多发性硬化症和关节炎。
-
Patent Agency Ranking
公开(公告)号：US4177281A
公开(公告)日：1979-12-04
申请号：US876618
申请日：1978-02-10
Applicant: James B. Mercer
Inventor： James B. Mercer
IPC: A61K31/415
CPC classification number: A61K31/415 , Y10S514/896
Abstract: The administration internally to humans of 1-(.beta.-hydroxethyl)-2-methyl-5-nitromidazole, (metronidazole) in a dosage range for adult humans of about 31 to 2,500 mgs per twenty-four hour period, is an effective therapeutic treatment for measles.
Abstract translation: 对于成人的剂量范围内，每二十四小时内给予1-（β-羟乙基）-2-甲基-5-硝唑唑（甲硝唑）的人体内给予约31-2500mg的治疗是一种有效的治疗方法 麻疹。
-
公开(公告)号：US5885996A
公开(公告)日：1999-03-23
申请号：US923117
申请日：1997-09-04
Applicant: Stephen E. Webber , Ted M. Bleckman , John Attard , Terrence R. Jones , Michael D. Varney
Inventor： Stephen E. Webber , Ted M. Bleckman , John Attard , Terrence R. Jones , Michael D. Varney
IPC: A61K31/505 , A61K31/517 , A61P31/04 , A61P31/10 , A61P35/00 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/93 , C07D239/95 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/12 , A61K31/54 , C07D403/02
CPC classification number: C07D401/12 , C07D239/90 , C07D239/93 , C07D239/95 , C07D403/06 , C07D403/12 , C07D417/12 , Y10S514/895 , Y10S514/896 , Y10S514/898
Abstract: Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
Abstract translation: 显示抗增殖活性的喹唑啉化合物，例如抗肿瘤活性，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物的用途。 这些化合物抑制细菌，酵母和真菌等高等生物和微生物细胞的生长和增殖。 优选的喹唑啉化合物能够抑制胸苷酸合酶的酶。 由抑制酶胸苷酸合酶导致的效果包括上述讨论。
-
公开(公告)号：US5370873A
公开(公告)日：1994-12-06
申请号：US944201
申请日：1992-09-11
Applicant: Iroka J. Udeinya
Inventor： Iroka J. Udeinya
CPC classification number: A61K36/58 , Y10S514/896 , Y10S514/934
Abstract: The present invention relates to purified extracts from Neem leaves. The extracts inhibit the adhesion of infectious cells and cancer cells to endothelial cells. The extracts also inhibit viruses, and malaria parasites in both the asexual and sexual forms. The invention also relates to a method of extraction, and pharmaceutical preparations containing the purified extracts.
Abstract translation: 本发明涉及来自楝树叶的纯化提取物。 提取物抑制感染细胞和癌细胞对内皮细胞的粘附。 提取物还可以无性和有性的形式抑制病毒和疟疾寄生虫。 本发明还涉及提取方法和含有纯化提取物的药物制剂。
-
公开(公告)号：US4221794A
公开(公告)日：1980-09-09
申请号：US50785
申请日：1979-06-21
Applicant: Lionel N. Simon , John W. Hadden
Inventor： Lionel N. Simon , John W. Hadden
IPC: C07D473/00 , C07D473/30 , C07D473/34 , C07D473/38 , A01N43/90
CPC classification number: C07D473/00 , C07D473/30 , C07D473/34 , C07D473/38 , Y10S514/885 , Y10S514/888 , Y10S514/894 , Y10S514/896 , Y10S514/897 , Y10S514/908 , Y10S514/934
Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
Abstract translation: 其中X是OH，NH2，SH，OR或SR（其中R是1至4个碳原子的烷基或苄基），R1是H或1至8个碳原子的烷基，R2是H或 甲基，Y是下式的胺的盐，其中R 3和R 4是低级烷基，例如1至4个碳原子，n是与对乙酰氨基苯甲酸的2至4的整数，并且其中z是数 0至10作为抗病毒剂可用作免疫调节剂，在特定情况下可具有抗白血病活性。 其中z为1至10的化合物和组合物本身是新颖的。 当R2为H时，Y的存在增强了免疫调节活性和抗病毒活性。 如果X是NH2，则具有免疫抑制活性，但没有免疫刺激（免疫激活）活性。
-
公开(公告)号：US4133959A
公开(公告)日：1979-01-09
申请号：US725160
申请日：1976-09-21
Applicant: Joseph C. Collins , Guy D. Diana
Inventor： Joseph C. Collins , Guy D. Diana
CPC classification number: C07D295/15 , C07C323/00 , C07C45/68 , C07C65/40 , Y10S514/868 , Y10S514/894 , Y10S514/896 , Y10S514/897 , Y10S514/908 , Y10S514/934
Abstract: Aryloxyalkyl diketones, useful as anti-viral agents, are prepared from an aryloxyalkyl halide and an alkali metal enolate salt of a diketone or keto-ester, or from a haloalkyl-diketone and an alkali metal salt of a phenol.
Abstract translation: 可用作抗病毒剂的芳氧基烷基二酮由二酮或酮酯的芳氧基烷基卤化物和碱金属烯醇盐，或卤代烷基 - 二酮和苯酚的碱金属盐制备。
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.012 seconds)
