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公开(公告)号:US06962984B2
公开(公告)日:2005-11-08
申请号:US09730559
申请日:2000-12-07
申请人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei , Kenji Shibata , Akiko Furuya
发明人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei , Kenji Shibata , Akiko Furuya
CPC分类号: C12Q1/6809 , A61K48/00 , C07K14/47 , G01N33/6893
摘要: A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.
摘要翻译: 与健康人的白细胞相比,IgA肾病患者的白细胞中的表达水平波动的新型DNA,分离DNA的方法,DNA编码的新型蛋白质,识别蛋白质的抗体,检测蛋白质和DNA的方法 ,以及IgA肾病的诊断和治疗方法。
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公开(公告)号:US06790944B1
公开(公告)日:2004-09-14
申请号:US09129603
申请日:1998-08-05
申请人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
发明人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
IPC分类号: C07H2102
CPC分类号: C07K14/47
摘要: The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.
摘要翻译: 本发明涉及从IgA肾病患者的白细胞分离的新型蛋白质和编码该蛋白质的DNA。 它还涉及基于与DNA互补的核苷酸序列的寡核苷酸,与蛋白特异性反应的抗体,以及包含它的IgA肾病的诊断和治疗药物。
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公开(公告)号:US06828428B2
公开(公告)日:2004-12-07
申请号:US09090672
申请日:1998-06-04
申请人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Nishimura , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei
发明人: Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Nishimura , Satoshi Nakagawa , Tatsunari Nishi , Tetsuro Kuga , Shigemasa Sawada , Masami Takei
IPC分类号: C07H2102
CPC分类号: G01N33/6893 , A61K48/00 , C07K14/47 , C12Q1/6809
摘要: The present invention relates to a novel DNA related to IgA nephropathy obtained by a differential display method [FEBS Letters, 351, 231 (1994)] taking note of an mRNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a method for detecting the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, a method for detecting the protein, and diagnosis and treatment of IgA nephropathy.
摘要翻译: 本发明涉及通过差异显示法获得的与IgA肾病有关的新型DNA [FEBS Letters,351,231(1994)],注意到与IgA肾病患者的白细胞相比,其表达水平波动的mRNA与健康白细胞相比 人,分离DNA的方法,DNA检测方法,由DNA编码的新型蛋白质,识别蛋白质的抗体,检测蛋白质的方法以及诊断和治疗IgA肾病。
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