公开(公告)号：US06828428B2

公开(公告)日：2004-12-07

申请号：US09090672

申请日：1998-06-04

申请人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Nishimura ,  Satoshi Nakagawa ,  Tatsunari Nishi ,  Tetsuro Kuga ,  Shigemasa Sawada ,  Masami Takei

发明人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Nishimura ,  Satoshi Nakagawa ,  Tatsunari Nishi ,  Tetsuro Kuga ,  Shigemasa Sawada ,  Masami Takei

IPC分类号： C07H2102

CPC分类号： G01N33/6893 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6809

摘要： The present invention relates to a novel DNA related to IgA nephropathy obtained by a differential display method [FEBS Letters, 351, 231 (1994)] taking note of an mRNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a method for detecting the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, a method for detecting the protein, and diagnosis and treatment of IgA nephropathy.

摘要翻译： 本发明涉及通过差异显示法获得的与IgA肾病有关的新型DNA [FEBS Letters，351,231（1994）]，注意到与IgA肾病患者的白细胞相比，其表达水平波动的mRNA与健康白细胞相比 人，分离DNA的方法，DNA检测方法，由DNA编码的新型蛋白质，识别蛋白质的抗体，检测蛋白质的方法以及诊断和治疗IgA肾病。

公开(公告)号：US06790944B1

公开(公告)日：2004-09-14

申请号：US09129603

申请日：1998-08-05

申请人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Kawabata ,  Satoshi Nakagawa ,  Tetsuro Kuga ,  Tatsunari Nishi ,  Nobuo Nomura ,  Takahiro Nagase ,  Shigemasa Sawada ,  Masami Takei

发明人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Kawabata ,  Satoshi Nakagawa ,  Tetsuro Kuga ,  Tatsunari Nishi ,  Nobuo Nomura ,  Takahiro Nagase ,  Shigemasa Sawada ,  Masami Takei

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.

摘要翻译： 本发明涉及从IgA肾病患者的白细胞分离的新型蛋白质和编码该蛋白质的DNA。 它还涉及基于与DNA互补的核苷酸序列的寡核苷酸，与蛋白特异性反应的抗体，以及包含它的IgA肾病的诊断和治疗药物。

公开(公告)号：US5865908A

公开(公告)日：1999-02-02

申请号：US788796

申请日：1997-01-27

申请人： Masami Takei ,  Hideto Fujita ,  Ryoji Fujino

发明人： Masami Takei ,  Hideto Fujita ,  Ryoji Fujino

IPC分类号： C23C8/24 ,  C23C8/26

CPC分类号： C23C8/24 ,  C23C8/26

摘要： A composite diffusion type nitriding method and a composite diffusion type nitriding apparatus of the present invention are effectively used for nitriding various materials, such as machine parts, as well as a material which is difficult for nitriding by a conventional method. The composite diffusion nitriding apparatus is formed of a container filled with solid granular materials, a furnace for housing the container therein, a nitriding gas introduction path for introducing the nitriding gas into the container, and an exhausting path for exhausting the gas from the container. In the method, the material to be nitrided is placed in the solid granular materials, and the nitriding gas is supplied to flow through the solid granular materials to thereby nitride the material.

摘要翻译： 本发明的复合扩散型氮化方法和复合扩散型氮化装置有效地用于氮化各种材料，例如机械部件，以及通过常规方法难以氮化的材料。 复合扩散氮化装置由填充有固体颗粒材料的容器，用于容纳容器的炉子，用于将氮化气体引入容器的渗氮气体引入路径和用于从容器排出气体的排气路径形成。 在该方法中，将待氮化的材料置于固体颗粒材料中，并且将氮化气体供给流过固体颗粒材料，从而氮化该材料。

公开(公告)号：US06962984B2

公开(公告)日：2005-11-08

申请号：US09730559

申请日：2000-12-07

申请人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Kawabata ,  Satoshi Nakagawa ,  Tatsunari Nishi ,  Tetsuro Kuga ,  Shigemasa Sawada ,  Masami Takei ,  Kenji Shibata ,  Akiko Furuya

发明人： Tetsuyoshi Ishiwata ,  Mikiko Sakurada ,  Ayako Kawabata ,  Satoshi Nakagawa ,  Tatsunari Nishi ,  Tetsuro Kuga ,  Shigemasa Sawada ,  Masami Takei ,  Kenji Shibata ,  Akiko Furuya

IPC分类号： A61K48/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68 ,  C07H21/02 ,  C07H21/04 ,  C12N5/00

CPC分类号： C12Q1/6809 ,  A61K48/00 ,  C07K14/47 ,  G01N33/6893

摘要： A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.

摘要翻译： 与健康人的白细胞相比，IgA肾病患者的白细胞中的表达水平波动的新型DNA，分离DNA的方法，DNA编码的新型蛋白质，识别蛋白质的抗体，检测蛋白质和DNA的方法 ，以及IgA肾病的诊断和治疗方法。