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公开(公告)号：US06790944B1
公开(公告)日：2004-09-14
申请号：US09129603
申请日：1998-08-05
申请人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
发明人： Tetsuyoshi Ishiwata , Mikiko Sakurada , Ayako Kawabata , Satoshi Nakagawa , Tetsuro Kuga , Tatsunari Nishi , Nobuo Nomura , Takahiro Nagase , Shigemasa Sawada , Masami Takei
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.
摘要翻译： 本发明涉及从IgA肾病患者的白细胞分离的新型蛋白质和编码该蛋白质的DNA。 它还涉及基于与DNA互补的核苷酸序列的寡核苷酸，与蛋白特异性反应的抗体，以及包含它的IgA肾病的诊断和治疗药物。
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公开(公告)号：US07829083B2
公开(公告)日：2010-11-09
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C12N5/10 , C12N5/12 , G01N33/53
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US07344838B2
公开(公告)日：2008-03-18
申请号：US11007517
申请日：2004-12-07
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US20050079539A1
公开(公告)日：2005-04-14
申请号：US11007517
申请日：2004-12-07
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US20090258022A1
公开(公告)日：2009-10-15
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , G01N33/566 , A61P37/02
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US06716613B1
公开(公告)日：2004-04-06
申请号：US10009332
申请日：2001-12-10
申请人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
发明人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.
摘要翻译： 本发明提供了具有引起关节疾病的聚集蛋白聚糖酶活性的新型金属蛋白酶，编码该金属蛋白酶的基因，上述金属蛋白酶的启动子，使用上述金属蛋白酶进行药物筛选的方法和抑制降解的药物组合物 蛋白多糖，其包含作为活性成分的能够抑制上述金属蛋白酶的聚集蛋白聚糖酶活性的物质。
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公开(公告)号：US06852836B1
公开(公告)日：2005-02-08
申请号：US09831846
申请日：1999-11-18
IPC分类号： C07K14/705 , C12N1/21 , C12N15/12 , C12P21/08 , C07K14/47
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ protein binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ蛋白结合基序。
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公开(公告)号：US20120135067A1
公开(公告)日：2012-05-31
申请号：US13376009
申请日：2010-06-04
申请人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
发明人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
IPC分类号： A61K9/127 , A61P37/04 , A61K39/02 , A61K39/09 , A61P31/16 , A61P31/00 , A61P11/06 , A61P19/02 , A61P11/00 , A61K9/00 , A61K39/145
CPC分类号： A61K39/0241 , A61K9/127 , A61K9/1272 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/55555 , A61K2039/55594 , Y02A50/403
摘要： Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.
摘要翻译： 公开了对支原体感染具有高治疗效果的疫苗，并且是高度安全的。 为了开发有效的支原体感染治疗方法，提供了作为支原体感染疫苗有效的支原体模拟颗粒，并且还提供了包括常见细菌的细菌模拟颗粒。 可以通过生产脂质体颗粒来提供细菌模拟颗粒，例如支原体模拟颗粒，其中作为构成脂质体的脂质组分含有诸如支原体的致病菌特异性的脂质抗原。 支原体模拟颗粒的施用使得能够诱导活体中有效的免疫活性。 支原体模拟颗粒可用作预防或治疗支原体感染的优良疫苗。
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9.发明授权
公开(公告)号：US5683556A
公开(公告)日：1997-11-04
申请号：US534889
申请日：1995-09-27
申请人： Nobuo Nomura , Fumiyoshi Shimizu
发明人： Nobuo Nomura , Fumiyoshi Shimizu
CPC分类号： H05F3/04
摘要： The invention provides a discharging method by which charges can be removed readily, uniformly and efficiently from a surface of a working object even where the surface has a complicated charge pattern of a large number of small positive and negative charged portions present closely to each other at random in a mixed condition. A working object is passed between a positive and negative ion producing discharging electrode and an ion attracting electrode opposed to the positive and negative ion producing discharging electrode and having a face extending in a travelling direction of the working object and a perpendicular direction. During such passage, high positive and negative voltages are applied alternately to the positive and negative ion producing discharging electrode to alternately produce positive and negative ions. Simultaneously, a high ac voltage is applied to the ion attracting electrode to induce positive and negative potentials in the working object so as to attract the positive and negative ions produced by the positive and negative ion producing discharging electrode by the induced potentials of the working object.
摘要翻译： 本发明提供了一种放电方法，即使在表面具有彼此紧密相对的大量小的正和负带电部分的复杂电荷模式的情况下，也可以容易地，均匀且有效地从工作对象的表面去除电荷， 随机在混合状态。 工作物体在正负离子产生放电电极和与正负离子产生放电电极相对的离子吸引电极之间通过，并且具有在工作对象的行进方向上延伸的面和垂直方向。 在这种通过期间，高正负电压交替地施加到正离子和负离子产生放电电极，以交替地产生正离子和负离子。 同时，向离子吸引电极施加高交流电压，以在工作对象中产生正电位和负电位，从而通过工作对象的感应电位吸引由正负离子产生放电电极产生的正离子和负离子 。
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公开(公告)号：US09539209B2
公开(公告)日：2017-01-10
申请号：US13376009
申请日：2010-06-04
申请人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
发明人： Kazuhiro Matsuda , Koji Ichiyama , Sachie Matsuda , Yuko Sasaki , Yoshichika Arakawa , Ryo Harasawa , Yoshihiro Nishida , Norio Katayama , Yasuo Endo , Nobuo Nomura
CPC分类号： A61K39/0241 , A61K9/127 , A61K9/1272 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/55555 , A61K2039/55594 , Y02A50/403
摘要： Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.
摘要翻译： 公开了对支原体感染具有高治疗效果的疫苗，并且是高度安全的。 为了开发有效的支原体感染治疗方法，提供了作为支原体感染疫苗有效的支原体模拟颗粒，并且还提供了包括常见细菌的细菌模拟颗粒。 可以通过生产脂质体颗粒来提供细菌模拟颗粒，例如支原体模拟颗粒，其中作为构成脂质体的脂质组分含有诸如支原体的致病菌特异性的脂质抗原。 支原体模拟颗粒的施用使得能够诱导活体中有效的免疫活性。 支原体模拟颗粒可用作预防或治疗支原体感染的优良疫苗。
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