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1.发明授权KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders 有权KASPP（LRRK2）基因，其生产和用于检测和治疗神经变性疾病公开(公告)号：US08409809B2
公开(公告)日：2013-04-02
申请号：US13219131
申请日：2011-08-26
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
IPC分类号： C12Q1/68
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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公开(公告)号：US20120064544A1
公开(公告)日：2012-03-15
申请号：US13084203
申请日：2011-04-11
申请人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
发明人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
IPC分类号： G01N21/76 , G01N21/64 , G01N33/566
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/1825 , A61K48/00 , C07K14/50 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to methods of diagnosing hypophosphatemic disorders.
摘要翻译： 本发明涉及诊断低磷血症的方法。
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3.发明授权KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders 有权KASPP（LRRK2）基因，其生产和用于检测和治疗神经变性疾病公开(公告)号：US08029986B2
公开(公告)日：2011-10-04
申请号：US11665875
申请日：2005-09-27
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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公开(公告)号：US20080241946A1
公开(公告)日：2008-10-02
申请号：US11983137
申请日：2007-11-07
申请人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
发明人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
IPC分类号： G01N33/68
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/1825 , A61K48/00 , C07K14/50 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.
摘要翻译： 本发明涉及用于诊断疾病的试剂盒，其包含检测FGF23多肽和突变型FGF23多肽的试剂。
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5.发明申请Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives 有权维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点公开(公告)号：US20050271644A1
公开(公告)日：2005-12-08
申请号：US10965694
申请日：2004-10-14
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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公开(公告)号：US08586317B2
公开(公告)日：2013-11-19
申请号：US13084203
申请日：2011-04-11
IPC分类号： G01N33/53 , A61K39/395
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/1825 , A61K48/00 , C07K14/50 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to methods of diagnosing hypophosphatemic disorders.
摘要翻译： 本发明涉及诊断低磷血症的方法。
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7.发明申请KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS 有权KASPP（LRRK2）基因，其生产和用途，用于检测和治疗神经损伤性疾病公开(公告)号：US20120035072A1
公开(公告)日：2012-02-09
申请号：US13219131
申请日：2011-08-26
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra (Leitner) Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra (Leitner) Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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8.发明申请Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives 审中-公开维生素K环氧化物回收多肽VKORC1，香豆素及其衍生物的治疗靶标公开(公告)号：US20110154520A1
公开(公告)日：2011-06-23
申请号：US12943260
申请日：2010-11-10
申请人： Johannes Oldenburg , Clemens R. Mueller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
发明人： Johannes Oldenburg , Clemens R. Mueller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
IPC分类号： A01K67/027 , C12N9/04 , C07H21/04 , C12N9/96 , C12N15/63 , C12N5/10 , C07H21/02 , C07K16/40 , C12Q1/68 , C12Q1/26 , G01N33/573 , C07D311/20
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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公开(公告)号：US07947810B2
公开(公告)日：2011-05-24
申请号：US11983190
申请日：2007-11-07
申请人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
发明人： Michael Econs , Ken White , Tim Matthias Strom , Thomas Meitinger
IPC分类号： C07K16/22
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , A61K38/1825 , A61K48/00 , C07K14/50 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.
摘要翻译： 本发明涉及用于诊断疾病的试剂盒，其包含检测FGF23多肽和突变型FGF23多肽的试剂。
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10.发明授权Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives 有权维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点公开(公告)号：US07939250B2
公开(公告)日：2011-05-10
申请号：US10965694
申请日：2004-10-14
申请人： Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
发明人： Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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