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1.发明授权KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders 有权KASPP（LRRK2）基因，其生产和用于检测和治疗神经变性疾病公开(公告)号：US08409809B2
公开(公告)日：2013-04-02
申请号：US13219131
申请日：2011-08-26
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
IPC分类号： C12Q1/68
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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2.发明授权KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders 有权KASPP（LRRK2）基因，其生产和用于检测和治疗神经变性疾病公开(公告)号：US08029986B2
公开(公告)日：2011-10-04
申请号：US11665875
申请日：2005-09-27
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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3.发明申请KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS 有权KASPP（LRRK2）基因，其生产和用途，用于检测和治疗神经损伤性疾病公开(公告)号：US20120035072A1
公开(公告)日：2012-02-09
申请号：US13219131
申请日：2011-08-26
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra (Leitner) Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Johannes Gloeckner , Thomas Gasser , Petra (Leitner) Herzig , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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4.发明申请Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders 有权Kaspp（lrrk2）基因，其生产和用于检测和治疗神经退行性疾病公开(公告)号：US20100235933A1
公开(公告)日：2010-09-16
申请号：US11665875
申请日：2005-09-27
申请人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Gloeckner , Thomas Gasser , Petra Leitner , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
发明人： Thomas Meitinger , Tim Matthias Strom , Saskia Biskup , Marius Ueffing , Elisabeth Kremmer , Christian Gloeckner , Thomas Gasser , Petra Leitner , Friedrich Asmus , Nadja Patenge , Alexander Zimprich , Matthew J. Farrer , Jennifer M. Kachergus , Sara J. Lincoln , Mary M. Hulihan , Zibigniew Wszolek , Ryan Uitti
IPC分类号： A01K67/00 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , C12P21/06 , C12Q1/68 , C40B30/06 , A61K31/7088 , C07K16/00
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译： 本发明涉及一种新发现的基因名为KASPP，用于与帕金森综合征相关的激酶，具有多形性病理学，或者称为LRRK2用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病 疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。
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公开(公告)号：US08455243B2
公开(公告)日：2013-06-04
申请号：US13172412
申请日：2011-06-29
CPC分类号： A01K67/0275 , C12N9/1205 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： A polynucleotide consisting of the base sequence of SEQ ID NO:2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.
摘要翻译： 由SEQ ID NO：2的碱基序列或其互补链组成的多核苷酸，其中X是由碱基A，C或T定义的基团之一。对该多核苷酸特异性的引物和探针，其中 引物和/或探针含有至少10个连续的核苷酸，最后使用探针来证明帕金森综合征遗传。
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公开(公告)号：US20080009454A1
公开(公告)日：2008-01-10
申请号：US10568414
申请日：2005-12-19
CPC分类号： A01K67/0275 , C12N9/1205 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at the least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.
摘要翻译： 由SEQ ID NO：2的碱基序列或其互补链组成的多核苷酸，其中X是由碱基A，C或T定义的基团之一。对该多核苷酸特异性的引物和探针，其中 引物和/或探针含有至少10个连续核苷酸，最后使用探针来证明帕金森综合征遗传。
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公开(公告)号：US20120030781A1
公开(公告)日：2012-02-02
申请号：US13172412
申请日：2011-06-29
IPC分类号： A01K67/027 , C12N15/85 , C12N15/63
CPC分类号： A01K67/0275 , C12N9/1205 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： A polynucleotide consisting of the base sequence of SEQ ID NO:2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.
摘要翻译： 由SEQ ID NO：2的碱基序列或其互补链组成的多核苷酸，其中X是由碱基A，C或T定义的基团之一。对该多核苷酸特异性的引物和探针，其中 引物和/或探针含有至少10个连续的核苷酸，最后使用探针来证明帕金森综合征遗传。
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公开(公告)号：US20110092565A1
公开(公告)日：2011-04-21
申请号：US12416140
申请日：2009-03-31
IPC分类号： A61K31/7105 , A61P25/28
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12N2310/3521
摘要： Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
摘要翻译： 本发明特征的方面涉及用于抑制α-突触核蛋白（SNCA）基因表达的组合物和方法，例如用于治疗神经变性疾病。 本文特征的针对SNCA基因的抗SNCA试剂可以被修饰以改变有利于神经细胞的分布。
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公开(公告)号：US07544786B2
公开(公告)日：2009-06-09
申请号：US10568414
申请日：2005-12-19
CPC分类号： A01K67/0275 , C12N9/1205 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at the least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.
摘要翻译： 由SEQ ID NO：2的碱基序列或其互补链组成的多核苷酸，其中X是由碱基A，C或T定义的基团之一。对该多核苷酸特异性的引物和探针，其中 引物和/或探针含有至少10个连续核苷酸，最后使用探针来证明帕金森综合征遗传。
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