公开(公告)号：US20170202789A1

公开(公告)日：2017-07-20

申请号：US15326016

申请日：2015-07-16

申请人： Frederick A. Sexton ,  Timothy S. Tracy ,  Sitaraman Krishnan ,  Vankat K. Vendra ,  James M. Myrick

发明人： Frederick A. Sexton ,  Timothy S. Tracy ,  Sitaraman Krishnan ,  Vankat K. Vendra ,  James M. Myrick

IPC分类号： A61K31/155 ,  A61K31/198 ,  A61K31/22 ,  A61K9/16 ,  A61K31/519 ,  A61K31/522 ,  A61K31/7072 ,  A61K31/7004 ,  A61K31/4164

CPC分类号： A61K31/155 ,  A61K9/1652 ,  A61K31/198 ,  A61K31/22 ,  A61K31/4164 ,  A61K31/519 ,  A61K31/522 ,  A61K31/7004 ,  A61K31/7072

摘要： The present invention relates to methods and compositions for improved drug bioavailability and disease treatment, including treatment of diseases related to hormone modulation or CNS function. In certain embodiments, the instant invention provides methods for hormone modulation or improving CNS function, comprising administering to a subject in need thereof a composition comprising one or more hydrogel particles, wherein the one or more hydrogel particles are non-toxic and incorporate at least one active agent, wherein the one or more hydrogel particles release the active agent in a time-controlled and sustained manner in vivo.

公开(公告)号：US07165550B1

公开(公告)日：2007-01-23

申请号：US10379078

申请日：2003-03-03

申请人： Timothy S. Tracy ,  Douglas D. Glover ,  Patrick S. Callery ,  Andrew P. Soisson ,  James E. Smith

发明人： Timothy S. Tracy ,  Douglas D. Glover ,  Patrick S. Callery ,  Andrew P. Soisson ,  James E. Smith

IPC分类号： A61F6/06

CPC分类号： A61F6/08 ,  A61F6/12 ,  A61F13/26

摘要： A cervical isolation and delivery apparatus having a cervical cap removably connected to a syringe such that a bottom opening of the cervical cap is in communication with an internal chamber of the syringe. The syringe is an elongated hollow tube with an elongated rod slidable disposed within an internal chamber of the elongated hollow tube. The cervical cap is removably connected to an application end of the elongated hollow tube such that upon insertion of the apparatus into a patient's vagina, the cervical cap covers the patient's cervix while protecting the tissue surrounding the cervix. The patient's cervix is treated by placing medication, e.g., one or more therapeutic agents, in the elongated hollow tube such that the elongated rod is in an extended position, inserting the apparatus into a patient's vagina, positioning the cervical cap over the patient's cervix, and pushing the elongated rod through the internal chamber of the elongated hollow tube until it is in a retracted position, thereby expelling the medication from the internal chamber into and through the cervical cap and into contact with the patient's cervix. The cervical cap covers and isolates the cervix thereby preventing the medication from leaking from the cervical area and irritating surrounding tissue.

摘要翻译： 一种宫颈分离和输送装置，其具有可拆卸地连接到注射器的颈帽，使得颈帽的底部开口与注射器的内部室连通。 注射器是细长的中空管，其细长杆可滑动地设置在细长中空管的内部腔室内。 颈部帽可移除地连接到细长中空管的应用端，使得当将装置插入患者的阴道中时，颈部帽覆盖患者的子宫颈，同时保护围绕子宫颈的组织。 通过将细长杆放置在延伸位置，将该装置插入患者的阴道内，将颈盖定位在病人的子宫颈上来治疗患者的子宫颈，例如将一种或多种治疗药物放置在细长的中空管中， 并且将细长的杆推动通过细长的中空管的内部腔，直到其处于缩回位置，从而将药物从内部室排出并穿过颈帽并与患者的子宫颈接触。 宫颈帽覆盖并隔离宫颈，从而防止药物从颈部区域泄漏并刺激周围组织。

公开(公告)号：US06526980B1

公开(公告)日：2003-03-04

申请号：US09649170

申请日：2000-08-25

申请人： Timothy S. Tracy ,  Douglas D. Glover ,  Patrick S. Callery ,  Leo R. Brancazio ,  Barbara L. McFarlin ,  Andrew P. Soisson ,  James E. Smith

发明人： Timothy S. Tracy ,  Douglas D. Glover ,  Patrick S. Callery ,  Leo R. Brancazio ,  Barbara L. McFarlin ,  Andrew P. Soisson ,  James E. Smith

IPC分类号： A61F606

CPC分类号： A61F6/08 ,  A61F6/12 ,  A61F13/26

摘要： An cervical drug delivery apparatus having an absorbent cylindrical structure with a cervical cap attached to one end. One or more therapeutic agents are applied to the internal surface of the cervical cap. The cervical drug delivery apparatus is housed within an applicator and inserted into a patient's vagina. Upon deployment of the cervical drug delivery apparatus, the cervical cap is automatically positioned over the patient's cervix providing for the direct application of the therapeutic agents on the patient's cervix. Alternative features of the cervical drug delivery apparatus include, a break-away cylindrical structure, a collapsible support structure for the cervical cap, an inflatable means for supporting the cervical cap, and the ability of the cylindrical structure and/or the cervical cap to contain one or more therapeutic agents that can be delivered by outside means.

摘要翻译： 具有吸收性圆柱形结构的颈部药物递送装置，其一端连接有颈帽。 将一种或多种治疗剂施用于宫颈帽的内表面。 宫颈药物输送装置容纳在施用器内并插入患者的阴道中。 在部署宫颈药物递送装置时，子宫颈帽被自动定位在患者子宫颈上方，用于将治疗剂直接施用于患者的子宫颈上。 子宫颈药物输送装置的替代特征包括：分离式圆柱形结构，用于颈帽的可折叠支撑结构，用于支撑颈帽的可膨胀装置，以及圆柱形结构和/或颈帽的容纳能力 可通过外部手段递送的一种或多种治疗剂。