Small Molecule Inhibitors of Toll-Like Receptor 9
    2.
    发明申请
    Small Molecule Inhibitors of Toll-Like Receptor 9 审中-公开
    Toll样受体的小分子抑制剂9

    公开(公告)号:US20100160314A1

    公开(公告)日:2010-06-24

    申请号:US12439924

    申请日:2007-09-05

    摘要: Small molecule compounds and compositions containing said compounds useful for inhibiting signaling by certain Toll-like receptors (TLRs), particularly TLR9, are provided. The compounds and compositions can be used to inhibit immune responses, including unwanted immune responses in particular. Compounds, compositions, and methods are provided to treat a variety of conditions involving unwanted immune responses, including for example autoimmune disease, inflammation, transplant rejection, and sepsis.

    摘要翻译: 提供了含有用于抑制某些Toll样受体(TLR)特异性TLR9的信号传导的所述化合物的小分子化合物和组合物。 化合物和组合物可用于抑制免疫应答,特别是包括不期望的免疫应答。 提供化合物,组合物和方法以治疗涉及不想要的免疫应答的各种病症,包括例如自身免疫疾病,炎症,移植排斥和败血症。

    Host adapter for combining I/O completion reports and method of using the same
    3.
    发明授权
    Host adapter for combining I/O completion reports and method of using the same 有权
    用于组合I / O完成报告的主机适配器及其使用方法

    公开(公告)号:US06434630B1

    公开(公告)日:2002-08-13

    申请号:US09282341

    申请日:1999-03-31

    IPC分类号: G06F1314

    CPC分类号: G06F13/24 G06F13/385

    摘要: An input/output (I/O) controller in an I/O system processes I/O requests from a host computer to a plurality of I/O devices. The I/O controller generates an interrupt to the host computer and reports a plurality of completed I/O requests from the I/O devices when at least one condition of the I/O system is met. A first condition of the I/O system comprises a predetermined ratio between the total number of unreported I/O completions by the I/O devices and the total number of remaining I/O requests from the host computer. A second condition comprises the expiration of a timer, which starts when the number of remaining I/O requests left to process for any individual I/O device reaches a predetermined minimum limit.

    摘要翻译: I / O系统中的输入/输出(I / O)控制器处理从主机到多个I / O设备的I / O请求。 当满足I / O系统的至少一个条件时,I / O控制器向主机计算机产生中断并报告来自I / O设备的多个完成的I / O请求。 I / O系统的第一条件包括I / O设备的未通报的I / O完成总数与来自主计算机的剩余I / O请求总数之间的预定比例。 第二个条件包括定时器的到期,当定时器的剩余I / O请求的数量达到预定的最小限度时,该定时器的开始。