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公开(公告)号：US20120238751A1
公开(公告)日：2012-09-20
申请号：US13496188
申请日：2012-03-14
申请人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
发明人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
IPC分类号： C07D487/04 , C07D471/10 , C07D487/08 , C07D471/08 , C07D487/10 , C07D491/048 , C07D491/056 , C07D487/14 , C07D471/14 , C07D471/04 , C07D498/04
CPC分类号： C07D487/04 , C07D487/14
摘要： Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
摘要翻译： 本文公开了具有式I结构的化合物及其药学上合适的盐，酯和前药，其可用作抗菌三环类回旋酶抑制剂。 还考虑了相关的药物组合物，用途和制备化合物的方法。
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2.发明授权
公开(公告)号：US5077277A
公开(公告)日：1991-12-31
申请号：US403232
申请日：1989-09-05
IPC分类号： A61K31/70 , A61K31/7024 , A61K31/7048 , A61P31/04 , C07H7/02 , C07H13/04 , C07H15/26
摘要： Derivatives of antibiotics derived from the microorganism Streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta, are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections.
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3.发明授权4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof 失效4-甲氧基-5-甲基 - 吡喃-3-醇天然产物及其衍生物
公开(公告)号：US5270334A
公开(公告)日：1993-12-14
申请号：US908767
申请日：1992-07-01
IPC分类号： C07D309/10 , C07D405/04 , C07H15/12 , C07H15/26 , A01N43/16
CPC分类号： C07D405/04 , C07D309/10 , C07H15/12 , C07H15/26
摘要： Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
摘要翻译： 公开了具有通式“IMAGE”I的新型抗生素物质，包括新型天然产物，其中R1和R2如本文所定义。 已经发现这些化合物是细胞色素P450抑制剂。
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公开(公告)号：US5294725A
公开(公告)日：1994-03-15
申请号：US305338
申请日：1989-01-31
IPC分类号： C07D309/10 , C07D405/04 , C07H15/12 , C07H15/26
CPC分类号： C07D405/04 , C07D309/10 , C07H15/12 , C07H15/26
摘要： A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.
摘要翻译： 通过培养微生物菌株Scopulariopsis，A.T.C.C.制备新型抗生素物质Scopularin。 第20,914号。 该化合物及其醇衍生物也被发现具有细胞色素P450抑制活性。
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公开(公告)号：US09732083B2
公开(公告)日：2017-08-15
申请号：US13496188
申请日：2012-03-14
申请人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
发明人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
IPC分类号： C07D487/04 , C07D487/14
CPC分类号： C07D487/04 , C07D487/14
摘要： Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
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