公开(公告)号：US20130079323A1

公开(公告)日：2013-03-28

申请号：US13394985

申请日：2010-09-10

Applicant: Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

Inventor： Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

IPC: C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D487/16 ,  C07D513/04

CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D471/16 ,  C07D487/04 ,  C07D487/16 ,  C07D491/048 ,  C07D513/04

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I), wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.

Abstract translation: 新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。 公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

公开(公告)号：US20130042332A1

公开(公告)日：2013-02-14

申请号：US13507945

申请日：2012-08-08

Applicant: Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

Inventor： Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

IPC: A01K67/00 ,  F41B11/32 ,  A01K29/00 ,  F41B11/00

CPC classification number: A61B5/4064 ,  A01K29/00 ,  A22B3/02 ,  A61B5/1036 ,  A61B5/6803 ,  A61B2503/40 ,  A61B2562/0247 ,  F41B11/60 ,  G01L5/0052

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

公开(公告)号：US20120204971A1

公开(公告)日：2012-08-16

申请号：US13236510

申请日：2011-09-19

Applicant: Wenjie Wu ,  Ping Yu ,  Yuan Tian ,  Zhiyong Chen

Inventor： Wenjie Wu ,  Ping Yu ,  Yuan Tian ,  Zhiyong Chen

IPC: F02B43/00

CPC classification number: F02C3/22 ,  F02C3/28 ,  F02C7/22 ,  F05D2220/722 ,  F05D2260/20 ,  F23K5/007 ,  F23K2401/10 ,  F23K2401/201 ,  F23K2900/05001 ,  Y02E20/16 ,  Y02E20/18 ,  Y02T50/675 ,  Y10T137/6416

Abstract: A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.

Abstract translation: 系统包括冷却器，该冷却器构造成冷却压缩气体燃料的第一气体部分并排出冷却的流体。 冷却的流体包括冷却的气体部分和冷却的液体部分。 该系统还包括分离器，该分离器被构造成将冷却的流体分离成冷却的气体部分和冷却的液体部分;以及混合罐，其被配置成将压缩气体燃料的第二气体部分与冷却的气体部分彼此直接接触， 产生过热气体燃料。 过热气体燃料包括一个超过燃烧系统下限阈值的过热度。

公开(公告)号：USD651137S1

公开(公告)日：2011-12-27

申请号：US29384113

申请日：2011-01-26

Applicant: Guogui Lai ,  Youheng Qian ,  Zhangping Yuan ,  Hui Xu ,  Zhiyong Chen ,  Minqiang Xiong

Designer： Guogui Lai ,  Youheng Qian ,  Zhangping Yuan ,  Hui Xu ,  Zhiyong Chen ,  Minqiang Xiong

公开(公告)号：USD590749S1

公开(公告)日：2009-04-21

申请号：US29303066

申请日：2008-01-31

Applicant: Guogui Lai ,  Youheng Qian ,  Zhangping Yuan ,  Hui Xu ,  Zhiyong Chen ,  Minqiang Xiong

Designer： Guogui Lai ,  Youheng Qian ,  Zhangping Yuan ,  Hui Xu ,  Zhiyong Chen ,  Minqiang Xiong

公开(公告)号：USD478696S1

公开(公告)日：2003-08-19

申请号：US29137875

申请日：2001-03-02

Applicant: Chao Li ,  Shuchun Wang ,  Zhiyong Chen ,  Bo Sun

Designer： Chao Li ,  Shuchun Wang ,  Zhiyong Chen ,  Bo Sun

公开(公告)号：US09732083B2

公开(公告)日：2017-08-15

申请号：US13496188

申请日：2012-03-14

Applicant: Daniel Bensen ,  Zhiyong Chen ,  John Finn ,  Thanh To Lam ,  Suk Joong Lee ,  Xiaoming Li ,  Douglas W. Phillipson ,  Leslie William Tari ,  Michael Trzoss ,  Junhu Zhang ,  Felice C. Lightstone ,  Toan B. Nguyen ,  Sergio E. Wong ,  Paul Aristoff ,  Michael Jung

Inventor： Daniel Bensen ,  Zhiyong Chen ,  John Finn ,  Thanh To Lam ,  Suk Joong Lee ,  Xiaoming Li ,  Douglas W. Phillipson ,  Leslie William Tari ,  Michael Trzoss ,  Junhu Zhang ,  Felice C. Lightstone ,  Toan B. Nguyen ,  Sergio E. Wong ,  Paul Aristoff ,  Michael Jung

IPC: C07D487/04 ,  C07D487/14

CPC classification number: C07D487/04 ,  C07D487/14

Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

公开(公告)号：US09051880B2

公开(公告)日：2015-06-09

申请号：US13236510

申请日：2011-09-19

Applicant: Wenjie Wu ,  Ping Yu ,  Yuan Tian ,  Zhiyong Chen

Inventor： Wenjie Wu ,  Ping Yu ,  Yuan Tian ,  Zhiyong Chen

IPC: G05D23/13 ,  F02C3/22 ,  F02C3/28 ,  F02C7/22 ,  F23K5/00

CPC classification number: F02C3/22 ,  F02C3/28 ,  F02C7/22 ,  F05D2220/722 ,  F05D2260/20 ,  F23K5/007 ,  F23K2401/10 ,  F23K2401/201 ,  F23K2900/05001 ,  Y02E20/16 ,  Y02E20/18 ,  Y02T50/675 ,  Y10T137/6416

Abstract: A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.

Abstract translation: 系统包括冷却器，该冷却器构造成冷却压缩气体燃料的第一气体部分并排出冷却的流体。 冷却的流体包括冷却的气体部分和冷却的液体部分。 该系统还包括分离器，该分离器被构造成将冷却的流体分离成冷却的气体部分和冷却的液体部分;以及混合罐，其被配置成将压缩气体燃料的第二气体部分与冷却的气体部分彼此直接接触， 产生过热气体燃料。 过热气体燃料包括一个超过燃烧系统下限阈值的过热度。

公开(公告)号：US09481675B2

公开(公告)日：2016-11-01

申请号：US13394985

申请日：2010-09-10

Applicant: Christopher J Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

Inventor： Christopher J Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

IPC: C07D487/04 ,  C07D519/00 ,  C07D471/04 ,  C07D487/16 ,  C07D491/048 ,  C07D513/04

CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D471/16 ,  C07D487/04 ,  C07D487/16 ,  C07D491/048 ,  C07D513/04

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula I are disclosed: wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.

Abstract translation: 新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。 公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

公开(公告)号：US08973565B2

公开(公告)日：2015-03-10

申请号：US13507945

申请日：2012-08-08

Applicant: Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

Inventor： Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

IPC: F41B11/32

CPC classification number: A61B5/4064 ,  A01K29/00 ,  A22B3/02 ,  A61B5/1036 ,  A61B5/6803 ,  A61B2503/40 ,  A61B2562/0247 ,  F41B11/60 ,  G01L5/0052

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Abstract translation: 在实验室动物身上造成脑损伤的装置和方法，该实验动物采用支撑实验室动物的平台。 平台定义了用于将实验室动物的头部定位在开口上的开口。 弹射器从位于平台开口下方的射弹发射装置发射。 射弹发射装置具有在所述平台的开口处和/或通过所述平台的开口直接推进射弹的手段，从而通过射弹的压力波或震荡冲击对动物造成脑部伤害。 没有头盔，射弹的直接影响会导致严重的创伤性脑损伤。 使用头盔保护动物免受颅骨骨折，硬膜下血肿，脑内出血和挫伤，但产生轻度脑震荡样病理。