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公开(公告)号：US20090023216A1
公开(公告)日：2009-01-22
申请号：US11776313
申请日：2007-07-11
Applicant: Tod Woolf
Inventor： Tod Woolf
CPC classification number: C12N15/113 , A61K31/713 , C12N13/00 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/351 , C12N2310/53 , C12N2320/31 , C12N2320/50 , C12N2320/51 , C12Y207/11022 , C12Y301/03048
Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
Abstract translation: 公开了具有比现有技术中教导的那些改进的性能的反义序列，包括双链RNAi组合物。 本发明提供了在体外系统和治疗上制备和使用这两者的优化的反义寡聚体组合物和方法。 本发明还提供了制备和使用改进的反义寡聚体组合物的方法。
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公开(公告)号：US20050202541A1
公开(公告)日：2005-09-15
申请号：US11035693
申请日：2005-01-14
Applicant: Amy Arrow , Roderic Dale , Tod Woolf
Inventor： Amy Arrow , Roderic Dale , Tod Woolf
IPC: C12N15/113 , A61K48/00 , C07H21/02 , C12P19/34
CPC classification number: C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527
Abstract: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
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公开(公告)号：US20060009409A1
公开(公告)日：2006-01-12
申请号：US11049636
申请日：2005-02-02
Applicant: Tod Woolf
Inventor： Tod Woolf
CPC classification number: C12N15/113 , A61K31/713 , C12N13/00 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/351 , C12N2310/53 , C12N2320/31 , C12N2320/50 , C12N2320/51 , C12Y207/11022 , C12Y301/03048
Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
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4.发明授权Nucleic acid molecules with novel chemical compositions capable of modulating gene expression 有权具有能够调节基因表达的新化学成分的核酸分子公开(公告)号：US06673611B2
公开(公告)日：2004-01-06
申请号：US09866316
申请日：2001-05-25
Applicant: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
Inventor： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC: C12Q168
CPC classification number: C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
Abstract: This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
Abstract translation: 本发明涉及具有特异性结构的新化学修饰的核酸分子，其表现出对核酸酶的增加的抗性和增加的对靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。
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Patent Agency Ranking
公开(公告)号：US08815821B2
公开(公告)日：2014-08-26
申请号：US13277957
申请日：2011-10-20
Applicant: Tod Woolf
Inventor： Tod Woolf
IPC: C12N15/11
CPC classification number: C12N15/113 , A61K31/713 , C12N13/00 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/351 , C12N2310/53 , C12N2320/31 , C12N2320/50 , C12N2320/51 , C12Y207/11022 , C12Y301/03048
Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.
Abstract translation: 公开了具有比现有技术中教导的那些改进的性能的反义序列，包括双链RNAi组合物。 本发明提供了在体外系统和治疗上制备和使用这两者的优化的反义寡聚体组合物和方法。 本发明还提供了制备和使用改进的反义寡聚体组合物的方法。
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公开(公告)号：US20090093433A1
公开(公告)日：2009-04-09
申请号：US12185012
申请日：2008-08-01
Applicant: Tod Woolf , Kristin Wiederholt , Margaret Taylor
Inventor： Tod Woolf , Kristin Wiederholt , Margaret Taylor
IPC: A61K31/7105 , C07H21/02 , C12P19/34
Abstract: The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.
Abstract translation: 本发明描述了稳定mRNA的新方法。 这些改变增加了mRNA的稳定性，并使其能够在有意义的RNA治疗中将细胞中的蛋白质转染表达。 因此，本发明涉及制备这种修饰的方法，包含这些修饰的组合物以及这些组合物在治疗疾病状态中的用途。
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7.发明申请'signalin' family of TGFbeta signal transduction proteins and uses related thereto 审中-公开“信号”家族的TGFbeta信号转导蛋白及其相关用途公开(公告)号：US20070117098A1
公开(公告)日：2007-05-24
申请号：US11251061
申请日：2005-10-14
Applicant: Jonathan Graff , Tod Woolf , Ping Jin , Douglas Melton
Inventor： Jonathan Graff , Tod Woolf , Ping Jin , Douglas Melton
IPC: C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC classification number: C12Q1/6886 , A61K48/00 , C07K14/4702 , C12Q2600/136
Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in a signal transduction induced by members of the TGFβ superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
Abstract translation: 本发明涉及由脊椎动物家族（称为这里称为信号蛋白相关基因）编码的蛋白质的参与由TGFbeta超家族成员诱导的信号转导的蛋白质的发现。 本发明提供可用于例如在体外和体内产生和/或维持不同脊椎动物组织阵列的组合物和方法。
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公开(公告)号：US20050176018A1
公开(公告)日：2005-08-11
申请号：US10715285
申请日：2003-11-17
Applicant: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
Inventor： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC: C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P5/30 , A61P35/00 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68
CPC classification number: C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
Abstract: This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
Abstract translation: 本发明涉及具有特异性结构的新型化学修饰的核酸分子，其表现出对核酸酶的增加的抗性并增加与靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。
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公开(公告)号：US5693532A
公开(公告)日：1997-12-02
申请号：US334847
申请日：1994-11-04
Applicant: James McSwiggen , Kenneth Draper , Pam Pavco , Tod Woolf
Inventor： James McSwiggen , Kenneth Draper , Pam Pavco , Tod Woolf
CPC classification number: C12N15/113 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
Abstract: An enzymatic RNA molecule which cleaves respiratory syncytial virus (RSV) genomic and RSV encoded RNA.
Abstract translation: 一种切断呼吸道合胞病毒（RSV）基因组和RSV编码RNA的酶RNA分子。
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