公开(公告)号：US20130302612A1

公开(公告)日：2013-11-14

申请号：US13601348

申请日：2012-08-31

Applicant: Michael Louis HAYDEN ,  Jeffrey Allen HANSON ,  Keith MELCHER ,  Robert Mark REYNOLDS ,  Patricia Ann CONSTANDINE

Inventor： Michael Louis HAYDEN ,  Jeffrey Allen HANSON ,  Keith MELCHER ,  Robert Mark REYNOLDS ,  Patricia Ann CONSTANDINE

IPC: C01B33/02

CPC classification number: C01B33/02 ,  C01B33/037 ,  Y10T428/2982

Abstract: Systems and methods and resulting compositions of matter including silicon solids from a mixture of silicon and water. The mixture is collected at a collection stage from at least one wafer abrasion process performed on a silicon surface having an impurity concentration 0.1 ppb and extracting one portion of the water from the mixture using at least one dryer stage to form a dry cake. The dry cake includes at least 99.99% silicon by weight excluding water and non-silicon species, where a concentration of water in the dry cake is between 0.05% and 1% by weight, and where a concentration of non-silicon species in the dry cake is between 0.05% and 1% by weight.

Abstract translation: 系统和方法以及所得的物质组合物，包括来自硅和水的混合物的硅固体。 在收集阶段从至少一个在杂质浓度为0.1ppb的硅表面上进行的晶片磨损过程收集混合物，并使用至少一个干燥器阶段从混合物中提取一部分水以形成干饼。 干饼包含至少99.99重量％的硅，不包括水和非硅物质，其中干饼中的水的浓度为0.05重量％至1重量％，并且其中干燥中的非硅物质的浓度 蛋糕的重量在0.05％至1％之间。

公开(公告)号：US20130260368A1

公开(公告)日：2013-10-03

申请号：US13823551

申请日：2011-09-16

Applicant: Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

Inventor： Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

IPC: C12Q1/70

CPC classification number: C12Q1/707 ,  C12Q1/6837 ,  C12Q1/703 ,  Y02A50/53 ,  Y02A50/54 ,  C12Q2525/161

Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.

Abstract translation: 本发明提供了通过可以在固定化探针中结合互补L-核酸的L-核酸尾部固定的嵌合捕获探针。 捕获探针可用于从样品中捕获靶核酸。 捕获探针尾部的L-核酸与固定化探针中的互补L-核酸结合，具有与否则相当于D-核酸的亲和力。 然而，捕获探针尾和固定化探针的L-核酸不与存在于含有靶核酸的样品中的D-核酸形成稳定的双链体。 将样品中的核酸直接与捕获探针的固定化探针或尾部的结合降低或消除，增加了测定的灵敏度和/或特异性。

公开(公告)号：US08277768B2

公开(公告)日：2012-10-02

申请号：US12271329

申请日：2008-11-14

Applicant: Michael Louis Hayden ,  Jeffrey Allen Hanson ,  Keith Melcher ,  Robert Mark Reynolds ,  Patricia Ann Constandine

Inventor： Michael Louis Hayden ,  Jeffrey Allen Hanson ,  Keith Melcher ,  Robert Mark Reynolds ,  Patricia Ann Constandine

IPC: C01B31/20

CPC classification number: C01B33/02 ,  C01B33/037 ,  Y10T428/2982

Abstract: Systems and methods and resulting compositions of matter including silicon solids from a mixture of silicon and water. The mixture is collected at a collection stage from at least one wafer abrasion process performed on a silicon surface having an impurity concentration ≦0.1 ppb and extracting one portion of the water from the mixture using at least one dryer stage to form a dry cake. The dry cake includes at least 99.99% silicon by weight excluding water and non-silicon species, where a concentration of water in the dry cake is between 0.05% and 1% by weight, and where a concentration of non-silicon species in the dry cake is between 0.05% and 1% by weight.

Abstract translation: 系统和方法以及所得的物质组合物，包括来自硅和水的混合物的硅固体。 在收集阶段从混合浓度为0.1ppb的硅表面上进行的至少一个晶片磨损过程收集混合物，并使用至少一个干燥器阶段从混合物中提取一部分水以形成干饼。 干饼包含至少99.99重量％的硅，不包括水和非硅物质，其中干饼中的水的浓度为0.05重量％至1重量％，并且其中干燥中的非硅物质的浓度 蛋糕的重量在0.05％至1％之间。

公开(公告)号：US07553830B2

公开(公告)日：2009-06-30

申请号：US10966174

申请日：2005-04-14

Applicant: Leonid Beigelman ,  Jasenka Matulic-Adamic ,  Alexander Karpeisky ,  Peter Haeberli ,  David Sweedler ,  Mark Reynolds ,  Nilabh Chaudhary ,  John Min

Inventor： Leonid Beigelman ,  Jasenka Matulic-Adamic ,  Alexander Karpeisky ,  Peter Haeberli ,  David Sweedler ,  Mark Reynolds ,  Nilabh Chaudhary ,  John Min

IPC: A61K31/26 ,  C07J9/00

CPC classification number: C07D213/64 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  C07C237/06 ,  C07C237/22 ,  C07C279/04 ,  C07C279/12 ,  C07C279/14 ,  C07H19/06 ,  C07J1/00 ,  C07J41/0005 ,  C07J43/003 ,  C07J51/00 ,  C12N15/88

Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Abstract translation: 本发明的特征在于渗透性增强剂分子和方法，以提高各种分子如核酸，多核苷酸，寡核苷酸，酶核酸分子，反义核酸分子，2-5A反义嵌合体，形成三链体的寡核苷酸，诱饵RNAS， dsRNA，siRNA，适体或含有核酸切割化学基团，肽，多肽，蛋白质，碳水化合物，类固醇，金属和小分子的反义核酸，从而促进这些分子的细胞摄取。

公开(公告)号：US20080021936A1

公开(公告)日：2008-01-24

申请号：US11840723

申请日：2007-08-17

Applicant: Mark Reynolds

Inventor： Mark Reynolds

IPC: G06F17/00

CPC classification number: G06F21/64 ,  G06F8/71 ,  G06F2221/2101 ,  G06F2221/2111

Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

Abstract translation: 本发明提供用于区分文件与可能存在的文件的任何或所有副本的工具和技术。 一种方法确定（204）文件的实际物理位置（512）并将物理位置与该文件相关联（214）作为文件的所声明的物理位置（516）。 然后可以通过找到（304）位置声明，从其读取（306）与文件相关联的所声明的物理位置来确定（308）文件的实际物理位置，并且（ 310）位置。 如果所声明的和实际的位置相同，则该文件是其声称的原始文件。 如果所声明的文件所述的物理位置与文件的实际物理位置之间存在差异，则它不是原始文件。

公开(公告)号：US20050148588A1

公开(公告)日：2005-07-07

申请号：US11040639

申请日：2005-01-21

Applicant: Daniel Burdick ,  Mark Stanley ,  David Oare ,  Mark Reynolds ,  Thomas Gadek ,  James Marsters

Inventor： Daniel Burdick ,  Mark Stanley ,  David Oare ,  Mark Reynolds ,  Thomas Gadek ,  James Marsters

IPC: C07D277/06 ,  A61K31/197 ,  A61K31/198 ,  A61K31/341 ,  A61K31/351 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/426 ,  A61K31/427 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4458 ,  A61K31/4462 ,  A61K31/4465 ,  A61K31/4525 ,  A61P1/04 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07C233/83 ,  C07D207/16 ,  C07D211/60 ,  C07D211/62 ,  C07D307/54 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  A61K31/537 ,  A61K31/195 ,  A61K31/381 ,  A61K31/421 ,  A61K31/495

CPC classification number: C07D405/12 ,  A61K31/198 ,  A61K31/40 ,  A61K31/44 ,  C07D207/16 ,  C07D277/06 ,  C07D307/54 ,  C07D417/12

Abstract: The invention relates to novel compounds having formula (I) wherein Cy, X, Y, L and R1-6 are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation and autoimmune diseases.

Abstract translation: 本发明涉及具有式（I）的新化合物，其中Cy，X，Y，L和R 1-6如本文所定义。 这些化合物结合CD11 / CD18粘附受体如淋巴细胞功能相关抗原-1（LFA-1），因此可用于治疗由LFA-1介导的疾病如炎症和自身免疫性疾病。

公开(公告)号：US06371723B1

公开(公告)日：2002-04-16

申请号：US09641825

申请日：2000-08-17

Applicant: Lloyd Grant ,  Mark Reynolds

Inventor： Lloyd Grant ,  Mark Reynolds

IPC: F01D102

CPC classification number: F04D29/043 ,  F04D7/065 ,  Y10T29/49885

Abstract: Disclosed is a shaft system particularly adapted for use in molten metal applications, such as injecting impellers, submersible molten metal pumps, and others. Embodiments of the shaft system contemplated by this invention very generally including a base shaft with an outer surface, a shaft sleeve composed of material adapted to be used in a molten metal environment, the shaft sleeve having an inner surface approximately corresponding in size to the outer surface of the shaft and located approximately concentrically around the shaft; and a shaft coupler between the outer surface of the shaft and the inner surface of the shaft sleeve; wherein the shaft sleeve is securely attached to the shaft by the expansion of the shaft coupler relative to the shaft and the shaft sleeve.

Abstract translation: 公开了一种特别适用于熔融金属应用的轴系统，例如喷射叶轮，潜水熔融金属泵等。 本发明设想的轴系的实施例非常通常包括具有外表面的基轴，由适于在熔融金属环境中使用的材料构成的轴套，所述轴套具有大致对应于外部尺寸的内表面 轴的表面并且大致同心地围绕轴定位; 以及在所述轴的外表面和所述轴套的内表面之间的轴联接器; 其中所述轴套通过所述轴联接器相对于所述轴和所述轴套的膨胀而牢固地附接到所述轴。

公开(公告)号：US09938590B2

公开(公告)日：2018-04-10

申请号：US13823551

申请日：2011-09-16

Applicant: Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

Inventor： Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

IPC: C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/707 ,  C12Q1/6837 ,  C12Q1/703 ,  Y02A50/53 ,  Y02A50/54 ,  C12Q2525/161

Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.

公开(公告)号：US07893072B2

公开(公告)日：2011-02-22

申请号：US10884379

申请日：2004-07-02

Applicant: Mark Reynolds ,  Paul Polakis

Inventor： Mark Reynolds ,  Paul Polakis

IPC: A01N43/54 ,  A01N43/42 ,  A61K31/58

CPC classification number: C07C233/58 ,  A61K31/00 ,  A61K31/16 ,  A61K31/175 ,  A61K31/513 ,  A61K31/66 ,  C07C233/59 ,  C07C233/60 ,  C07C2601/14 ,  C07C2602/08 ,  C07D239/22 ,  C07D295/096 ,  C07D295/135 ,  C07D307/58

Abstract: Compounds of the disclosure provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases. The disclosure encompasses compounds, analogs, prodrugs, metabolites, and pharmaceutically acceptable salts thereof, pharmaceutical compositions, and methods for prophylaxis and treatment of diseases and other maladies or conditions involving cancer, tumors, and like conditions. The disclosure also provides therapeutic methods including the administration of an effective amount of a compound of the disclosure.

Abstract translation: 本公开的化合物提供对预防和治疗诸如细胞增殖，血管生成或细胞凋亡介导的疾病等疾病或病症有效的组合物。 本公开包括其化合物，类似物，前药，代谢产物及其药学上可接受的盐，药物组合物和预防和治疗涉及癌症，肿瘤等病症和其它疾病或病症的方法。 本公开还提供治疗方法，包括施用有效量的本发明化合物。

公开(公告)号：US20100205112A1

公开(公告)日：2010-08-12

申请号：US12731192

申请日：2010-03-25

Applicant: Mark Reynolds ,  Marcia Reynolds

Inventor： Mark Reynolds ,  Marcia Reynolds

IPC: G06Q40/00 ,  G06F3/048

CPC classification number: G06Q40/00 ,  G06Q40/06

Abstract: The present invention involves a system and method for generating customized retirement plans for a user. A user interaction module for obtains user information and includes software for asking a plurality of questions relating to the user. The questions include at least one question relating to quantitative information of the retirement funds of the user and at least one question relating to qualitative information about the user. The advice module correlates user quantitative information on retirement funds and user qualitative information to generate a customized retirement plan for the user.

Abstract translation: 本发明涉及一种用于为用户生成定制退休计划的系统和方法。 一种用于获取用户信息的用户交互模块，并且包括用于询问与该用户有关的多个问题的软件。 这些问题至少包括一个与用户的退休基金的定量信息有关的问题，以及至少一个与用户定性信息有关的问题。 咨询模块将关于退休基金和用户定性信息的用户定量信息相关联，以为用户生成定制的退休计划。