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公开(公告)号：US07531499B2
公开(公告)日：2009-05-12
申请号：US11011278
申请日：2004-12-15
CPC分类号： A61K47/20 , A61K9/02 , A61K9/1617 , A61K9/1641 , A61K9/2013 , A61K9/2031 , A61K9/4808 , A61K9/5015 , A61K9/5026 , A61K31/38 , A61K31/4704 , A61K31/4709 , A61K47/183 , A61K47/34
摘要： The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an effect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.
摘要翻译： 本发明提供一种药物组合物，其包含（1）药理活性物质，（2）药物吸收剂和（3）牛磺酸化合物或多胺。 牛磺酸化合物具有抑制或预防肠粘膜损伤的效果，因此将牛磺酸化合物加入到含有药理活性物质和药物吸收剂的药物组合物中可以抑制或防止肠粘膜的损伤。 多胺改善药理活性物质的吸收性，因此将多胺添加到含有药理活性物质和药物吸收剂的药物组合物中可以减少药物吸收剂的剂量，从而抑制或防止肠粘膜的损伤。
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公开(公告)号：US07008920B2
公开(公告)日：2006-03-07
申请号：US11011035
申请日：2004-12-15
IPC分类号： A61K31/00
CPC分类号： A61K47/20 , A61K9/02 , A61K9/1617 , A61K9/1641 , A61K9/2013 , A61K9/2031 , A61K9/4808 , A61K9/5015 , A61K9/5026 , A61K31/38 , A61K31/4704 , A61K31/4709 , A61K47/183 , A61K47/34
摘要： The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.
摘要翻译： 本发明提供一种药物组合物，其包含（1）药理活性物质，（2）药物吸收剂和（3）牛磺酸化合物或多胺。 牛磺酸化合物具有抑制或预防肠粘膜损伤的效果，因此将牛磺酸化合物加入到含有药理活性物质和药物吸收剂的药物组合物中可以抑制或预防肠粘膜的损伤。 多胺改善药理活性物质的吸收性，因此将多胺添加到含有药理活性物质和药物吸收剂的药物组合物中可以减少药物吸收剂的剂量，从而抑制或防止肠粘膜的损伤。
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公开(公告)号：US20050100530A1
公开(公告)日：2005-05-12
申请号：US11011278
申请日：2004-12-15
IPC分类号： A61K9/00 , A61K9/02 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/50 , A61K31/185 , A61K31/38 , A61K31/445 , A61K31/4704 , A61K31/4709 , A61K31/496 , A61K31/522 , A61K31/56 , A61K38/21 , A61K45/08 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/34 , A61P1/04 , A61P43/00 , A61K31/5513 , A61K31/655
CPC分类号： A61K47/20 , A61K9/02 , A61K9/1617 , A61K9/1641 , A61K9/2013 , A61K9/2031 , A61K9/4808 , A61K9/5015 , A61K9/5026 , A61K31/38 , A61K31/4704 , A61K31/4709 , A61K47/183 , A61K47/34
摘要： The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.
摘要翻译： 本发明提供一种药物组合物，其包含（1）药理活性物质，（2）药物吸收剂和（3）牛磺酸化合物或多胺。 牛磺酸化合物具有抑制或预防肠粘膜损伤的效果，因此将牛磺酸化合物加入到含有药理活性物质和药物吸收剂的药物组合物中可以抑制或预防肠粘膜的损伤。 多胺改善药理活性物质的吸收性，因此将多胺添加到含有药理活性物质和药物吸收剂的药物组合物中可以减少药物吸收剂的剂量，从而抑制或防止肠粘膜的损伤。
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公开(公告)号：US20050095290A1
公开(公告)日：2005-05-05
申请号：US11011035
申请日：2004-12-15
IPC分类号： A61K9/00 , A61K9/02 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/50 , A61K31/185 , A61K31/38 , A61K31/445 , A61K31/4704 , A61K31/4709 , A61K31/496 , A61K31/522 , A61K31/56 , A61K38/21 , A61K45/08 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/34 , A61P1/04 , A61P43/00
CPC分类号： A61K47/20 , A61K9/02 , A61K9/1617 , A61K9/1641 , A61K9/2013 , A61K9/2031 , A61K9/4808 , A61K9/5015 , A61K9/5026 , A61K31/38 , A61K31/4704 , A61K31/4709 , A61K47/183 , A61K47/34
摘要： The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.
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5.发明申请公开(公告)号：US20050158375A1
公开(公告)日：2005-07-21
申请号：US11078502
申请日：2005-03-14
申请人： Toshikiro Kimura , Kazutaka Higaki , Ken-ichi Ogawara , Toshiya Kai , Jun-ichi Yokoe , Shiho Sakuragi , Makoto Sato
发明人： Toshikiro Kimura , Kazutaka Higaki , Ken-ichi Ogawara , Toshiya Kai , Jun-ichi Yokoe , Shiho Sakuragi , Makoto Sato
IPC分类号： A61K9/127 , A61K47/48 , A61K38/38 , A61K31/704
CPC分类号： A61K9/1272 , A61K47/62 , A61K47/6911
摘要： The present invention provides liposome-containing drug administration carriers that have improved residence time in the blood and improved migration into tumor cells as compared with conventional ones and that have reduced accumulation in the heart, and a pharmaceutical composition for treating a cancer that includes liposomes containing an antitumor active substance and having polyalkylene glycol and albumin bound thereto and that can be incorporated in large amounts in the cancer cells.
摘要翻译： 本发明提供了含有脂质体的药物给药载体，其与常规的相比具有改善的在血液中的停留时间和改善的向肿瘤细胞的迁移，并且降低了在心脏中的积聚，以及用于治疗癌症的药物组合物，其包含含有 抗肿瘤活性物质，其结合有聚亚烷基二醇和白蛋白，并且可以大量掺入癌细胞中。
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公开(公告)号：US06884768B2
公开(公告)日：2005-04-26
申请号：US10480598
申请日：2002-06-14
IPC分类号： A61K9/00 , A61K9/02 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/50 , A61K31/185 , A61K31/38 , A61K31/445 , A61K31/4704 , A61K31/4709 , A61K31/496 , A61K31/522 , A61K31/56 , A61K38/21 , A61K45/08 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/34 , A61P1/04 , A61P43/00 , A61K31/00
CPC分类号： A61K47/20 , A61K9/02 , A61K9/1617 , A61K9/1641 , A61K9/2013 , A61K9/2031 , A61K9/4808 , A61K9/5015 , A61K9/5026 , A61K31/38 , A61K31/4704 , A61K31/4709 , A61K47/183 , A61K47/34
摘要： The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal mucous membrane, and therefore adding the taurine compound to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to suppress or prevent damage of the intestinal mucosa. A polyamine improves the absorbability of pharmacologically active substances, and therefore adding the polyamine to a medicinal composition containing a pharmacologically active substance and a drug absorbefacient makes it possible to decrease the dose of the drug absorbefacient, thereby suppressing or preventing damage of the intestinal mucosa.
摘要翻译： 本发明提供一种药物组合物，其包含（1）药理活性物质，（2）药物吸收剂和（3）牛磺酸化合物或多胺。 牛磺酸化合物具有抑制或预防肠粘膜损伤的效果，因此将牛磺酸化合物加入到含有药理活性物质和药物吸收剂的药物组合物中可以抑制或预防肠粘膜的损伤。 多胺改善药理活性物质的吸收性，因此将多胺添加到含有药理活性物质和药物吸收剂的药物组合物中可以减少药物吸收剂的剂量，从而抑制或防止肠粘膜的损伤。
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