公开(公告)号：US06818430B1

公开(公告)日：2004-11-16

申请号：US09980453

申请日：2002-02-12

申请人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

发明人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

IPC分类号： C12P1902

CPC分类号： C12R1/18 ,  C12P19/02 ,  C12R1/38 ,  C12R1/64

摘要： Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, there is used inexpensive myo-inositol as a starting compound. That is, there is now developed a new process which comprises reacting myo-inositol with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. Further, a novel process is provided, which comprises reacting the so produced L-epi-2-inosose with a reducing agent made of an alkali metal boron hydride or any other alkali metal hydride in an aqueous reaction medium, to produce epi-inositol and myo-inositol, and then isolating epi-inositol from the resulting reaction product composed of the epi-inositol and myo-inositol.

摘要翻译： 提供了用于有效生产L-外 - 二糖和外消旋肌醇的新方法，其可用作各种药物或用于合成各种药物的中间体。 在这些方法中，使用廉价的肌醇作为起始化合物。 也就是说，现在开发了一种新的方法，其包括使肌醇与能够将肌醇转化为L-表 - 2-inosose的革兰氏阴性细菌反应，从而通过转化肌内 - 肌醇进入L-epi-2-inosose。 此外，提供了一种新的方法，其包括使如此制备的L-表 - 2-异糖与在水性反应介质中由碱金属硼氢化物或任何其它碱金属氢化物制成的还原剂反应，以产生表肌醇和 肌醇，然后从由肌醇和肌醇组成的反应产物中分离表肌醇。

公开(公告)号：US07157268B2

公开(公告)日：2007-01-02

申请号：US10852153

申请日：2004-05-25

申请人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

发明人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

IPC分类号： C12P19/02 ,  C12N1/20

CPC分类号： C12R1/18 ,  C12P19/02 ,  C12R1/38 ,  C12R1/64

摘要： Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, inexpensive myo-inositol is used as a starting compound which is reacted with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. A biologically pure culture of Pseudomonas sp. AB 10215 strain is also provided which has a characteristic nature of being capable of converting myo-inositol into L-epi-2-inosose.

摘要翻译： 提供了用于有效生产L-外 - 二糖和外消旋肌醇的新方法，其可用作各种药物或用于合成各种药物的中间体。 在该方法中，使用廉价的肌醇作为起始化合物，其与能够将肌醇转化为L-外 - 二糖的革兰氏阴性细菌反应，从而通过转化产生L-表二-2-糖 的肌醇变为L-epi-2-inosose。 假单胞菌属的生物纯培养物 还提供了AB 10215菌株，其特征在于能够将肌醇转化为L-表 - 2-inosose。