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    METHOD FOR FERMENTATIVE PRODUCTION OF N-ACETYL-D-GLUCOSAMINE BY MICROORGANISM
    1.
    发明申请
    METHOD FOR FERMENTATIVE PRODUCTION OF N-ACETYL-D-GLUCOSAMINE BY MICROORGANISM 有权
    通过微生物发酵制备N-乙酰-D-葡萄糖胺的方法

    公开(公告)号：US20110059489A1

    公开(公告)日：2011-03-10

    申请号：US12944592

    申请日：2010-11-11

    申请人： Tetsuya Mori ,  Wakako Ichikawa ,  Yuichi Kita ,  Yasuyuki Tetsuka

    发明人： Tetsuya Mori ,  Wakako Ichikawa ,  Yuichi Kita ,  Yasuyuki Tetsuka

    IPC分类号： C12P19/26

    CPC分类号： C12R1/885 ,  C12P19/26

    摘要： N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB 10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate N-acetyl-D-glucosamine in the culture medium and then collecting N-acetyl-D-glucosamine from the culture medium.

    摘要翻译： N-乙酰基-D-葡糖胺可以通过培养能够产生N-乙酰基-D-葡糖胺的真菌，例如木霉木霉AB 10282菌株（FERM BP-10623）或哈茨木霉AB10283菌株（FERM BP-10624）， 在补充有除甲壳素和几丁质寡糖以外的碳源的培养基和氮源中，在培养基中产生并积累N-乙酰基-D-葡糖胺，然后从培养基中收集N-乙酰基-D-葡糖胺。

    Maleimide compounds having improved in storage stability
    2.
    发明授权
    Maleimide compounds having improved in storage stability 失效
    具有改善的储存稳定性的马来酰亚胺化合物

    公开(公告)号：US5556991A

    公开(公告)日：1996-09-17

    申请号：US256829

    申请日：1994-09-22

    申请人： Yuichi Kita ,  Koichi Nakagawa ,  Kazuo Kishino

    发明人： Yuichi Kita ,  Koichi Nakagawa ,  Kazuo Kishino

    IPC分类号： C07D207/44 ,  C07D207/448 ,  C07D207/452 ,  C08F22/36 ,  C08F222/40

    CPC分类号： C07D207/448

    摘要： The present invention provides a stabilized maleimide compound which is hard to discolor during storage. The maleimide compound has a content of primary amines of not more than 500 ppm or further has a content of maleic anhydride in the range of 5 to 2,000 ppm or a content of 2-amino-N-substituted succinimide compounds of not more than 300 ppm. Furthermore, it is preferable that the content of chlorine compounds reduced as a chlorine atom is not more than 10 ppm and further the content of volatile components having a boiling point of not more than 200.degree. C. at normal pressure is not more than 2,000 ppm.

    摘要翻译： PCT No.PCT / JP93 / 00112 Sec。 371日期1994年9月22日 102（e）1994年9月22日PCT 1993年1月29日PCT公布。 出版物WO93 / 15048 日期：1993年8月5日本发明提供一种稳定的马来酰亚胺化合物，其在储存期间难以变色。 马来酰亚胺化合物的伯胺含量为500ppm以下，或者还含有5〜2000ppm的马来酸酐含量或2-氨基-N-取代琥珀酰亚胺化合物的含量不大于300ppm 。 此外，作为氯原子还原的氯化合物的含量优选为10ppm以下，在常压下沸点为200℃以下的挥发成分的含量不大于2000ppm 。

    Method for manufacture of high-purity phthalic anhydride
    5.
    发明授权
    Method for manufacture of high-purity phthalic anhydride 失效
    制造高纯度邻苯二甲酸酐的方法

    公开(公告)号：US4436922A

    公开(公告)日：1984-03-13

    申请号：US394477

    申请日：1982-07-01

    申请人： Yuichi Kita ,  Kentaro Sakamoto ,  Takahisa Sato

    发明人： Yuichi Kita ,  Kentaro Sakamoto ,  Takahisa Sato

    IPC分类号： C07C51/573 ,  C07D307/89

    CPC分类号： C07C51/573

    摘要： A method for the manufacture of high-purity phthalic anhydride, which comprises exposing crude phthalic anhydride obtained by vapor-phase catalytic oxidation of ortho-xylene to contact with a gas containing molecular oxygen at an elevated temperature in the presence of an alkali metal salt of at least one carboxylic acid selected from the group consisting of maleic acid, succinic acid and benzoic acid, and optionally a manganese-containing alloy, and subsequently subjecting the resultant reaction mixture to distillation.

    摘要翻译： 一种制备高纯度邻苯二甲酸酐的方法，其包括将在邻二甲苯的气相催化氧化获得的粗邻苯二甲酸酐与含分子氧的气体在升高的温度下，在碱金属盐 至少一种选自马来酸，琥珀酸和苯甲酸的羧酸，以及任选的含锰合金，随后将所得反应混合物进行蒸馏。

    Method for producing scyllo-inositol
    6.
    发明授权
    Method for producing scyllo-inositol 有权
    鲨肌醇的制备方法

    公开(公告)号：US07745671B2

    公开(公告)日：2010-06-29

    申请号：US10576030

    申请日：2004-10-14

    申请人： Masanori Yamaguchi ,  Yuichi Kita ,  Tetsuya Mori ,  Kenji Kanbe ,  Akihiro Tomoda ,  Atsushi Takahashi ,  Wakako Ichikawa

    发明人： Masanori Yamaguchi ,  Yuichi Kita ,  Tetsuya Mori ,  Kenji Kanbe ,  Akihiro Tomoda ,  Atsushi Takahashi ,  Wakako Ichikawa

    IPC分类号： C07C35/16 ,  C07H1/06 ,  C07C35/46

    CPC分类号： C12P7/02 ,  C07C29/145 ,  C12N9/0004 ,  C12N9/0006 ,  C12P7/18 ,  C12P7/26

    摘要： It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.

    摘要翻译： 旨在提供一种新的NAD +独立肌醇2-脱氢酶，其在不存在NAD +的情况下将肌醇转化为鲨肌内糖; 在NADH或NADPH的存在下，立体选择性地将鲨肌内糖降解成鲨肌醇的新型鲨肌醇肌醇脱氢酶; 和属于醋杆菌属或伯克霍尔德氏菌属的新型微生物，可将肌醇转化为鲨肌醇。 通过使用这些酶或微生物，产生鲨肌醇。 此外，通过向含有鲨肌醇和除了鲨肌醇之外的中性糖的液体混合物中加入硼酸和金属盐以形成鲨肌醇/硼酸络合物，将所述络合物与液体混合物分离，将鲨肌醇纯化 将如此分离的络合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化鲨肌醇。

    Process for producing L-epi-2-inosose and novel process for producing epi-inositol
    7.
    发明授权
    Process for producing L-epi-2-inosose and novel process for producing epi-inositol 失效
    制备L-表 - 二烯糖的方法和制备表肌醇的新方法

    公开(公告)号：US06818430B1

    公开(公告)日：2004-11-16

    申请号：US09980453

    申请日：2002-02-12

    申请人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

    发明人： Atsushi Takahashi ,  Kenji Kanbe ,  Tetsuya Mori ,  Yuichi Kita ,  Tsuyoshi Tamamura ,  Tomio Takeuchi

    IPC分类号： C12P1902

    CPC分类号： C12R1/18 ,  C12P19/02 ,  C12R1/38 ,  C12R1/64

    摘要： Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, there is used inexpensive myo-inositol as a starting compound. That is, there is now developed a new process which comprises reacting myo-inositol with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. Further, a novel process is provided, which comprises reacting the so produced L-epi-2-inosose with a reducing agent made of an alkali metal boron hydride or any other alkali metal hydride in an aqueous reaction medium, to produce epi-inositol and myo-inositol, and then isolating epi-inositol from the resulting reaction product composed of the epi-inositol and myo-inositol.

    摘要翻译： 提供了用于有效生产L-外 - 二糖和外消旋肌醇的新方法，其可用作各种药物或用于合成各种药物的中间体。 在这些方法中，使用廉价的肌醇作为起始化合物。 也就是说，现在开发了一种新的方法，其包括使肌醇与能够将肌醇转化为L-表 - 2-inosose的革兰氏阴性细菌反应，从而通过转化肌内 - 肌醇进入L-epi-2-inosose。 此外，提供了一种新的方法，其包括使如此制备的L-表 - 2-异糖与在水性反应介质中由碱金属硼氢化物或任何其它碱金属氢化物制成的还原剂反应，以产生表肌醇和 肌醇，然后从由肌醇和肌醇组成的反应产物中分离表肌醇。

    Acrylonitrile solutions of maleimides, method for preparation thereof, and acrylonitrile based copolymers obtained by use of the solutions
    8.
    发明授权
    Acrylonitrile solutions of maleimides, method for preparation thereof, and acrylonitrile based copolymers obtained by use of the solutions 失效
    马来酰亚胺的丙烯腈溶液，其制备方法和使用该溶液得到的丙烯腈共聚物

    公开(公告)号：US06733693B1

    公开(公告)日：2004-05-11

    申请号：US09473415

    申请日：1999-12-29

    申请人： Kazuo Kishino ,  Kinichi Nakayama ,  Fumioki Shimoyama ,  Yuichi Kita

    发明人： Kazuo Kishino ,  Kinichi Nakayama ,  Fumioki Shimoyama ,  Yuichi Kita

    IPC分类号： C09K1535

    CPC分类号： C07D207/448 ,  C07C255/08

    摘要： An acrylonitrile solution of maleimide manifesting transparency, precluding coloration and opacification during the course of handling, and excelling in stability, a method for the preparation of the acrylonitrile solution, and an acrylonitrile based copolymer obtained by using the acrylonitrile solution are provided. The acrylonitrile solution of maleimide is such that, when it is subjected to a forced coloration test, the differences &Dgr;L, &Dgr;a, &Dgr;b values (invariably as absolute values) each between L, a, and b values before and after the test are respectively not more than 5, not more than 5, and not more than 10. The acrylonitrile solution of maleimide is prepared by lowering the water content in the acrylonitrile solution to a level of not more than 0.1% by weight, or causing the acrylonitrile solution to permit coexistence therein of a polymerization inhibitor and lowering the water content in the acrylonitrile solution to a level of not more than 0.3% by weight.

    摘要翻译： 提供了具有透明性的马来酰亚胺的丙烯腈溶液，在处理过程中排除了着色和不透明性，并且稳定性优异，制备丙烯腈溶液的方法以及使用丙烯腈溶液得到的丙烯腈共聚物。 马来酰亚胺的丙烯腈溶液使得当进行强制着色试验时，在试验前后的L，a和b值之间的差值DeltaL，Deltaa，Deltab值（总是绝对值）分别不是 大于5，不大于5，且不大于10.马来酰亚胺的丙烯腈溶液通过将丙烯腈溶液中的水含量降低至不超过0.1重量％，或使丙烯腈溶液允许 共聚抑制剂并将丙烯腈溶液中的水分降低到不超过0.3重量％的水平。