公开(公告)号：US09302967B2

公开(公告)日：2016-04-05

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： A61K31/14 ,  A61K31/05 ,  C07C39/19 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US07674487B2

公开(公告)日：2010-03-09

申请号：US11730433

申请日：2007-04-02

申请人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

发明人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC分类号： A61K36/67 ,  A61P35/02

CPC分类号： A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

摘要： A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

摘要翻译： 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US20070184131A1

公开(公告)日：2007-08-09

申请号：US11730433

申请日：2007-04-02

申请人： Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

发明人： Santu Bandyopadhyay ,  Keshab Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC分类号： A61K36/67

CPC分类号： A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

摘要： A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

摘要翻译： 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US20050282892A1

公开(公告)日：2005-12-22

申请号：US11174545

申请日：2005-07-06

申请人： Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

发明人： Santu Bandyopadhyay ,  Bikas Pal ,  Samir Bhattacharyay ,  Swapan Mondal ,  Chhabinath Mandal ,  Aditya Konar ,  Keshab Roy ,  Tanusree Biswas ,  Gautam Bandyopadhyay

IPC分类号： A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/235 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06

CPC分类号： A61K31/235 ,  A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/70 ,  A61K31/716 ,  A61K45/06 ,  A61K2300/00

摘要： This invention relates to a pharmaceutical composition useful for treating chronic myeloid leukemia where Bcr-Abl kinase is constitutively expressed in animals and humans, and a treatment of chronic myeloid leukemia (CML) by a composition comprising an effective amount of analogs and/or salts of chlorogenic acid. The analogs are preferably sodium chlorogenate (Na-Chl) or potassium or ammonium salts, which were prepared from Chlorogenic acid or its analogs.

摘要翻译： 本发明涉及一种用于治疗慢性骨髓性白血病的药物组合物，其中Bcr-Abl激酶在动物和人体中组成型表达，并且通过包含有效量的类似物和/或盐类型的组合物的组合物治疗慢性骨髓性白血病（CML） 绿原酸。 类似物优选由绿原酸或其类似物制备的氯酸钠（Na-Chl）或钾盐或铵盐。

公开(公告)号：US06773728B2

公开(公告)日：2004-08-10

申请号：US09985160

申请日：2001-11-01

申请人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharya

发明人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Roy ,  Bikash Chandra Pal ,  Ranjan Bhadra ,  Krishna Das ,  Samir Bhattacharya

IPC分类号： A61K3578

CPC分类号： A61K36/67 ,  A61K36/75 ,  A61K2300/00

摘要： This invention relates to an herbal composition for the treatment and remedy of bronchial respiratory difficulties, more particularly this invention describes the process of separation, physicochemical characterization and biological response evaluation of active components obtained from extracts of any plant parts including leaves, barks, roots and seeds of plants M. koenigii and P. betle in order to establish their role on the treatment and remedy of bronchial respiratory troubles.

摘要翻译： 本发明涉及用于治疗和补救支气管呼吸困难的草药组合物，更具体地，本发明描述了从任何植物部分（包括叶，树皮，根和根）的提取物获得的活性成分的分离过程，物理化学表征和生物反应评估， 植物M.koenigii和P. betle的种子，以确定其在支气管呼吸困难的治疗和补救方面的作用。

公开(公告)号：US06610332B2

公开(公告)日：2003-08-26

申请号：US10124459

申请日：2002-04-18

申请人： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

发明人： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

IPC分类号： A61K3578

CPC分类号： A61K36/67 ,  C12N9/0071 ,  Y02A50/409

摘要： This invention relates to method of treating visceral leishmaniasis or kala-azar by administering effective amount of betel leaf extract or lyophilized extract together with or associated with an additive and a composition comprising betel leaf extract with a pharmaceutically acceptable additive.

公开(公告)号：US08519154B2

公开(公告)日：2013-08-27

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

发明人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

IPC分类号： C07D209/82 ,  C07D209/88 ,  A61K31/403

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药路线以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。

公开(公告)号：US20120202868A1

公开(公告)日：2012-08-09

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata MUKHOPADHYAY ,  Mumu CHAKRABORTY ,  Tulika MUKHERJEE ,  Arun BANDYOPADHYAY ,  Dipak KAR ,  Tanima BANERJEE ,  Aditya KONAR ,  Debaprasad JANA ,  Siddhartha ROY ,  Santu BANDYOPADHYAY ,  Balram GHOSH ,  Mabalirajan ULAGANATHAN ,  Rakesh Kamal JOHRI ,  Subhash Chander SHARMA ,  Gurdarshan SINGH ,  Bholanath PAUL ,  Vasanta Madhava Sharma GANGAVARAM ,  Jhillu Singh YADAV ,  Radha Krishna PALAKODETY

发明人： Sibabrata MUKHOPADHYAY ,  Mumu CHAKRABORTY ,  Tulika MUKHERJEE ,  Arun BANDYOPADHYAY ,  Dipak KAR ,  Tanima BANERJEE ,  Aditya KONAR ,  Debaprasad JANA ,  Siddhartha ROY ,  Santu BANDYOPADHYAY ,  Balram GHOSH ,  Mabalirajan ULAGANATHAN ,  Rakesh Kamal JOHRI ,  Subhash Chander SHARMA ,  Gurdarshan SINGH ,  Bholanath PAUL ,  Vasanta Madhava Sharma GANGAVARAM ,  Jhillu Singh YADAV ,  Radha Krishna PALAKODETY

IPC分类号： A61K31/403 ,  A61P11/06 ,  C07D209/86

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthama and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients. Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药途径以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。

公开(公告)号：US07638329B2

公开(公告)日：2009-12-29

申请号：US09800448

申请日：2001-03-05

申请人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Monidipa Gosh ,  Mitali Ray ,  Chiranjib Pal ,  Samir Bhattacharya

发明人： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Monidipa Gosh ,  Mitali Ray ,  Chiranjib Pal ,  Samir Bhattacharya

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/0639 ,  C12N2502/11

摘要： Described is an in vitro method for developing dendritic Langerhans type cells, for use in immunotherapy against cancer or infectious diseases and enhancement of graft survival in mammals. The method includes the steps of: culturing cells selected from peripheral blood monocytes and bone marrow cells in a medium containing platelets obtained from the same species or phylogenetically close species; and incubating the culture at 30 to 40° C. for a period sufficient to enable formation of mature dendritic Langerhans type cells.

摘要翻译： 描述了用于开发树突状朗格汉斯型细胞的体外方法，用于针对癌症或感染性疾病的免疫治疗和增强哺乳动物的移植物存活。 该方法包括以下步骤：在含有从相同物种或系统发育密切物种获得的血小板的培养基中培养选自外周血单核细胞和骨髓细胞的细胞; 并将培养物在30至40℃下孵育足以形成成熟树突状朗格汉斯型细胞的时间。

公开(公告)号：US06531166B2

公开(公告)日：2003-03-11

申请号：US09746017

申请日：2000-12-26

申请人： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

发明人： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

IPC分类号： A61K3578

CPC分类号： A61K36/67 ,  Y10S514/885

摘要： This invention relates to use of betel leaf extract to induce IFN&ggr; from human peripheral blood mononuclear cells and as a Th1 type immuno modulator, wherein the said method comprises the steps of, preparing water extract of betel leaf, preparation of human peripheral blood mononuclear cells, incubation of hPBMC with betel leaf extract for a period of 18-48 hours, extraction of RNA for cytokine specific RT-PCR or for flow cytometry for the detection of intracellular cytokine protein, subjecting RNA for RT-PCR to obtain PCR products using IFN&ggr; specific known primers, and enhancement of IFN&ggr; as reflected by IFN&ggr; specific band.