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公开(公告)号：US20230226253A1
公开(公告)日：2023-07-20
申请号：US17980684
申请日：2022-11-04
CPC分类号： A61L27/18 , A61L27/56 , A61L33/0041 , A61L33/0082 , C08J5/18 , A61L2430/36 , A61L2300/414 , A61L2300/42 , A61L2300/604 , B29L2031/7562
摘要： A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.
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公开(公告)号：US20220024084A1
公开(公告)日：2022-01-27
申请号：US17492862
申请日：2021-10-04
发明人： William Hudson Hofmeister , Alexander Yuryevich Terekhov , Jose Lino Vasconcelos da Costa , Kathleen Stacia Lansford , Deepak Rajput , Lloyd M. Davis
IPC分类号： B29C41/00 , B29C41/38 , B29C33/38 , G03F7/00 , B82Y10/00 , B82Y40/00 , B29C41/02 , B29C41/42 , C08B3/06 , C08B5/02 , C08F110/02 , C08F120/18 , C08F120/40 , C08G63/08 , C08G63/664 , C08G77/04
摘要： Solution casting a nanostructure. Preparing a template by ablating nanoholes in a substrate using single-femtosecond laser machining. Replicating the nanoholes by applying a solution of a polymer and a solvent into the template. After the solvent has substantially dissipated, removing the replica from the substrate.
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公开(公告)号：US11155007B2
公开(公告)日：2021-10-26
申请号：US14560833
申请日：2014-12-04
发明人： William Hudson Hofmeister , Alexander Yuryevich Terekhov , Jose Lino Vasconcelos da Costa , Kathleen Stacia Lansford , Deepak Rajput , Lloyd M. Davis
IPC分类号： B29C41/00 , B29C33/38 , B29C41/38 , G03F7/00 , B82Y10/00 , B82Y40/00 , B29C41/02 , B29C41/42 , C08B3/06 , C08B5/02 , C08F110/02 , C08F120/18 , C08F120/40 , C08G63/08 , C08G63/664 , C08G77/04 , B29L31/00 , B29K1/00 , B29K31/00 , B29K33/00 , B29K67/00 , B29K71/00 , B29K83/00
摘要： Solution casting a nanostructure. Preparing a template by ablating nanoholes in a substrate using single-femtosecond laser machining. Replicating the nanoholes by applying a solution of a polymer and a solvent into the template. After the solvent has substantially dissipated, removing the replica from the substrate.
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公开(公告)号：US20160222345A1
公开(公告)日：2016-08-04
申请号：US15014762
申请日：2016-02-03
发明人： William Hudson Hofmeister , Lucas Hofmeister , Alexander Yuryevich Terekhov , Jose Lino Vasconcelos da Costa
CPC分类号： C12N5/0068 , B29C67/20 , B29K2067/04 , B29K2101/12 , B29K2105/256 , C12N2533/30 , C12N2535/10
摘要： Embodiments of the presently disclosed subject matter provide biomimetic cell culture substrates comprising highly tunable patterned polymer nanofiber matrices capable of modulating expression of critical self-renewal factors and markers of cell-cell interaction to maintain stemness of human mesenchymal stem cells in vitro. Embodiments of the presently-disclosed subject matter also provide scalable, highly repeatable methods of making biomimetic cell culture substrates by hot pressing thermoplastic polymer films into femtosecond laser-ablated nanopore molds to form patterned polymer nanofiber matrices on flat thermoplastic substrates.
摘要翻译： 目前公开的主题的实施方案提供了包含高度可调图案的聚合物纳米纤维基质的仿生细胞培养基质，其能够调节临界自我更新因子的表达和细胞 - 细胞相互作用的标记以维持体外人间质干细胞的干性。 目前公开的主题的实施方案还提供可扩展的，高度可重复的制造仿生细胞培养基质的方法，其通过将热塑性聚合物膜热压到飞秒激光烧蚀的纳米孔模具中以在平坦的热塑性基材上形成图案化的聚合物纳米纤维基质。
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公开(公告)号：US11666841B2
公开(公告)日：2023-06-06
申请号：US17246929
申请日：2021-05-03
CPC分类号： B01D39/1623 , D04H3/016 , B01D2239/0618 , B01D2239/1208 , B01D2239/1233
摘要： Nanofiber filter media ribbons are flexible elongate strips of polymeric material having a surface on which is formed an array of nanofibers. Ribbons are formable into woven or non-woven mats. The array of nanofibers can be configured to filter a predetermined contaminant from a fluid stream passing through the mats. Filter ribbons are formable by applying a moldable polymer to a first angular location of a rotating cylindrical roll having an array of nanoholes formed in a circumferential surface thereof so that the polymer covers the surface of the roll and infiltrates the nanoholes; cooling the polymer while rotating the polymer-covered roll to a second angular position; and removing the cooled polymer from the roll as an elongate film having an array of nanofibers formed on a surface thereof by the polymer that infiltrated the nanoholes.
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公开(公告)号：US11491258B1
公开(公告)日：2022-11-08
申请号：US17461667
申请日：2021-08-30
摘要： A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.
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公开(公告)号：US20220347343A1
公开(公告)日：2022-11-03
申请号：US17462316
申请日：2021-08-31
摘要： A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.
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公开(公告)号：US11147900B1
公开(公告)日：2021-10-19
申请号：US17244908
申请日：2021-04-29
摘要： A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.
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公开(公告)号：US20210252440A1
公开(公告)日：2021-08-19
申请号：US17246929
申请日：2021-05-03
摘要： Nanofiber filter media ribbons are flexible elongate strips of polymeric material having a surface on which is formed an array of nanofibers. Ribbons are formable into woven or non-woven mats. The array of nanofibers can be configured to filter a predetermined contaminant from a fluid stream passing through the mats. Filter ribbons are formable by applying a moldable polymer to a first angular location of a rotating cylindrical roll having an array of nanoholes formed in a circumferential surface thereof so that the polymer covers the surface of the roll and infiltrates the nanoholes; cooling the polymer while rotating the polymer-covered roll to a second angular position; and removing the cooled polymer from the roll as an elongate film having an array of nanofibers formed on a surface thereof by the polymer that infiltrated the nanoholes.
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公开(公告)号：US11014029B2
公开(公告)日：2021-05-25
申请号：US16875067
申请日：2020-05-15
摘要： Nanofiber filter media ribbons are flexible elongate strips of polymeric material having a surface on which is formed an array of nanofibers. Ribbons are formable into woven or non-woven mats. The array of nanofibers can be configured to filter a predetermined contaminant from a fluid stream passing through the mats. Filter ribbons are formable by applying a moldable polymer to a first angular location of a rotating cylindrical roll having an array of nanoholes formed in a circumferential surface thereof so that the polymer covers the surface of the roll and infiltrates the nanoholes; cooling the polymer while rotating the polymer-covered roll to a second angular position; and removing the cooled polymer from the roll as an elongate film having an array of nanofibers formed on a surface thereof by the polymer that infiltrated the nanoholes.
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