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32 条记录 (耗时 0.015 秒)

    COMPREHENSIVE DETECTION OF SINGLE CELL GENETIC STRUCTURAL VARIATIONS
    1.
    发明申请
    COMPREHENSIVE DETECTION OF SINGLE CELL GENETIC STRUCTURAL VARIATIONS 有权

    公开(公告)号：US20220199196A1

    公开(公告)日：2022-06-23

    申请号：US17602895

    申请日：2020-04-09

    申请人： European Molecular Biology Laboratory ,  Universität des Saarlandes ,  Max-Planck-Gesellschaft zur Föerderung der Wissenschaften e.V.

    发明人： Jan KORBEL ,  Ashley SANDERS ,  Sascha MEIERS ,  David PORUBSKY ,  Maryam GHAREGHANI ,  Tobias MARSHALL

    IPC分类号： G16B20/20 ,  G16B30/00 ,  G16B50/00

    摘要： The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others. The method of the invention may further be applied in research to decipher the karyotypes of cellular models (cell lines), patient samples, or to further unravel genetic and mechanistic pathways leading to the generation of any SV within genomes.

    Method and evaluation device for evaluating projection data of an object being examined
    2.
    发明授权
    Method and evaluation device for evaluating projection data of an object being examined 有权

    公开(公告)号：US10134156B2

    公开(公告)日：2018-11-20

    申请号：US15319587

    申请日：2015-06-16

    申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Universität des Saarlandes

    发明人： Steven Oeckl ,  Alfred K. Louis ,  Tobias Schön

    IPC分类号： G06T11/00

    摘要： In a method and an evaluation device for the evaluation of projection data of an object being examined, which are determined along a trajectory in a multiplicity of projection positions relative to a co-ordinate origin, a particular trajectory function is determined for the projection positions, for each of a multiplicity of positions from a reconstruction region of dimension n by establishing an offset (d) and a direction vector at the co-ordinate origin, establishing a hyperplane of dimension n−1 which runs perpendicular to the direction vector and has an offset to the co-ordinate origin, establishing a number of intersection points where the hyperplane intersects the trajectory, establishing a derivative vector of the trajectory according to its trajectory path and calculating the derivative vector in the projection position, and establishing an absolute value of a scalar product between the derivative vector and the position and dividing the absolute value by the number. The determined trajectory functions are transformed to a frequency domain of dimension n and the projection data are evaluated by means of the transformed trajectory functions.

    METHOD AND SYSTEM FOR PROCESSING INPUT VALUES
    4.
    发明公开
    METHOD AND SYSTEM FOR PROCESSING INPUT VALUES 审中-公开

    公开(公告)号：US20240027977A1

    公开(公告)日：2024-01-25

    申请号：US18037626

    申请日：2021-11-19

    申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  UNIVERSITÄT DES SAARLANDES

    发明人： Heiko ZIMMERMANN ,  GüNTER FUHR ,  Antonie FUHR

    IPC分类号： G05B13/02 ,  G05B13/04

    CPC分类号： G05B13/027 ,  G05B13/042 ,  G06Q10/0637

    摘要： The invention relates to a method implemented in a control system of a machine for processing input values in an overall system with a working level and an evaluation level comprising



    inputting first input values to the working level and determining first output values; forming first situation data; inputting the first situation data to the evaluation level and determining first evaluations indicating whether the first situation data satisfy predetermined first conditions; influencing the determination of the first output values based on the first evaluations; inputting second input values to the working level and determining second output values, wherein the determination of the second output values is influenced by the first output values; forming second situation data; inputting the second situation data to the evaluation level and determining second evaluations indicating whether the second situation data satisfy predetermined second conditions, the determining of the second evaluations being influenced by the first evaluations; influencing the determining of the second output values based on the second evaluations; wherein the first and/or the second output values are used as overall output values of the overall system.

    Optimized Rendering with Eye Tracking in a Head-Mounted Display
    5.
    发明申请
    Optimized Rendering with Eye Tracking in a Head-Mounted Display 审中-公开

    公开(公告)号：US20190180723A1

    公开(公告)日：2019-06-13

    申请号：US16321922

    申请日：2017-08-01

    申请人： Universität Des Saarlandes

    发明人： Daniel Pohl ,  Xucong Zhang ,  Andreas Bulling

    IPC分类号： G09G5/391 ,  G06F3/01 ,  G06F3/02

    摘要： The invention is directed to a method and a device for controlling images in a head mounted display equipped with an eye tracker and worn by a user, comprising the following steps: detecting, with the eye-tracker, an eye gaze of at least one of the eyes of the user; controlling the images depending on the detected eye gaze; wherein the step of controlling the images comprises not rendering or not updating pixels (22) of the images that are not visible by the user at the detected eye gaze.

    COUPLING MULTIPLE ARTIFICIALLY LEARNING UNITS WITH A PROJECTION LEVEL
    8.
    发明申请
    COUPLING MULTIPLE ARTIFICIALLY LEARNING UNITS WITH A PROJECTION LEVEL 有权

    公开(公告)号：US20220292331A1

    公开(公告)日：2022-09-15

    申请号：US17612768

    申请日：2020-03-09

    申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  UNIVERSITÄT DES SAARLANDES

    发明人： Heiko ZIMMERMANN ,  Günter FUHR ,  Antonie FUHR

    IPC分类号： G06N3/04 ,  G06N3/08

    摘要： Provided are methods in a system of at least a second and a third artificial intelligence unit, comprising: inputting first input values to at least one second artificial intelligence unit, and obtaining output values based on the input values from the at least one second artificial intelligence unit; at least temporarily storing situation data, the situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values of the third artificial intelligence unit, the third artificial intelligence unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more predetermined conditions based on the third output values. Also provided is a system for carrying out such a method.

    MIRNAS AS BIOMARKERS FOR PARKINSON'S DISEASE
    9.
    发明申请
    MIRNAS AS BIOMARKERS FOR PARKINSON'S DISEASE 审中-公开

    公开(公告)号：US20200208219A1

    公开(公告)日：2020-07-02

    申请号：US16632222

    申请日：2018-07-18

    申请人： Hummingbird Diagnostics GmbH ,  Universität des Saarlandes

    发明人： Andreas KELLER ,  Mustafa Kahraman ,  Thomas Laufer ,  Jochen Kohlhaas

    IPC分类号： C12Q1/6883 ,  G01N1/28

    摘要： The present invention relates to a method for diagnosing Parkinson's disease (PD) in an individual. Further, the present invention relates to a method for determining the course of Parkinson's disease (PD) in an individual having PD. Furthermore, the present invention relates to a method for determining the risk for developing Parkinson's disease (PD) in an individual. In addition, the present invention relates to the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for diagnosing Parkinson's disease (PD) in the individual, the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual having Parkinson's disease (PD) for determining the course of PD in the individual, and/or the use of at least one polynucleotide for detecting at least one miRNA in a biological sample isolated from an individual for determining the risk of the individual to develop Parkinson's disease (PD). Moreover, the present invention relates to a kit for diagnosing Parkinson's disease (PD) in an individual, for determining the course of Parkinson's disease (PD) in an individual having PD, and/or for determining the risk for developing Parkinson's disease (PD) in an individual.