公开(公告)号：US10739356B2

公开(公告)日：2020-08-11

申请号：US15742484

申请日：2016-07-08

申请人： CHU DE NICE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS ,  UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS

发明人： Vincent Louis Marie Esnault ,  Barbara Polski ,  Gérard Jean Frantz Lambeau ,  Guillaume Dolla

IPC分类号： G01N33/53 ,  G01N33/68

摘要： Disclosed is a method for assessing the prognosis of idiopathic membranous nephropathy in a body fluid sample from a human subject, based on profiling PLA2R1 epitopes recognized by autoantibodies in the sample. The method further relates to analysis of PLA2R1 epitope spreading amongst three PLA2R1 domains (Cys R, CTLD1 and CTLD7) that are recognized by anti-PLA2R1 autoantibodies, two of which (CTLD1 and CTLD7) are more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.

公开(公告)号：US20200181089A1

公开(公告)日：2020-06-11

申请号：US16315930

申请日：2017-07-10

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  CHU DE NICE

发明人： Thierry PASSERON ,  Rachid BENHIDA ,  Pascal DAO ,  Gian Marco DE DONATIS ,  Anthony MARTIN

IPC分类号： C07D215/44 ,  C07D413/04 ,  C07D401/04 ,  C07D405/04 ,  A61P35/04

摘要： The present invention relates to a compound of general formula (I): said compound being as defined in claim (1). The invention also relates to a pharmaceutical composition comprising: —a compound of general formula (I) as defined in claim (12) and, —at least one antibody selected from an anti-PD1 antibody, an anti-CTLA4 antibody, an anti-PD-L1 antibody and a mixture of two or more thereof. The invention also relates to a compound of general formula (I) as defined in claim (17) for use in the treatment of cancer, said cancer being preferably selected from melanoma, bladder, kidney, prostate, colon, lung, breast and blood cancer.

公开(公告)号：US09879325B2

公开(公告)日：2018-01-30

申请号：US15121864

申请日：2015-02-27

申请人： ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS ,  UNIVERSITÉ PARIS DIDEROT (PARIS VII) ,  UNIVERSITÉ DE NICE—SOPHIA ANTIPOLIS ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Johanna Chiche ,  Catherine Thieblemont ,  Jean-Ehrland Ricci

IPC分类号： A61K39/395 ,  C07K16/30 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  C07K16/28

CPC分类号： C12Q1/6886 ,  C07K16/2887 ,  C07K16/3061 ,  C07K2317/24 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5052 ,  G01N33/57426 ,  G01N2333/90203 ,  G01N2800/52

摘要： The present invention relates to a method for predicting the responsiveness of a patient to a treatment with an anti-CD20 antibody, said method comprising measuring the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in B cells obtained from said patient.

公开(公告)号：US20140355998A1

公开(公告)日：2014-12-04

申请号：US14347739

申请日：2012-09-28

申请人： Université de Nice Sophia Antipolis ,  Centre National de la Research Scientifique-CNRS

发明人： Sébastien Tanzilli ,  Virginia D'Auria ,  Olivier Alibart ,  Anthony Christophe Mickaël Martin ,  Laurent Labonte

IPC分类号： H04L7/00 ,  H04B10/25 ,  H04B10/70

CPC分类号： H04L7/0075 ,  H04B10/25 ,  H04B10/70 ,  H04L9/0852

摘要： According to one aspect, the invention relates to a device (20) for synchronizing optical pumping entanglement sources (141, 142) in a quantum communication network, including a pulsed light source (21) enabling the emission of telecom-wavelength light pulses (I1,I2), which are distributed in parallel with all of the entanglement sources in order to provide an optical clock common to said entanglement sources and including, for each entanglement source, a device (243, 253) for converting the frequency of the distributed light pulse, thereby enabling a light pulse to be generated at a wavelength adapted to the optical pumping of the entanglement source in order to generate pairs of entangled photons.

摘要翻译： 根据一个方面，本发明涉及一种用于使量子通信网络中的光泵浦纠缠源（141,142）同步的装置（20），包括能够发射电信波长光脉冲（I1）的脉冲光源（21） ，I2），其与所有纠缠源平行分布，以便提供所述纠缠源公共的光时钟，并且对于每个纠缠源包括用于转换分布式光的频率的装置（243,253） 脉冲，从而使得能够以适合于缠绕源的光泵浦的波长产生光脉冲，以便产生成对的纠缠光子。

公开(公告)号：US20190290913A1

公开(公告)日：2019-09-26

申请号：US16347940

申请日：2017-11-08

申请人： GALVANI BIOELECTRONICS LIMITED ,  UNIVERSITÉ DE NICE SOPHIA-ANTIPOLIS ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

发明人： Philippe BLANCOU ,  Nicolas GLAICHENHAUS ,  Arun SRIDHAR

IPC分类号： A61N1/36

摘要： Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

公开(公告)号：US20220099497A1

公开(公告)日：2022-03-31

申请号：US17310393

申请日：2020-01-21

申请人： Centre National De La Recherche Scientifique ,  Observatoire De La Cote D'Azur ,  Université de Nice Sophia Antipolis ,  Université Grenoble Alpes

发明人： François HENAULT ,  Alain SPANG

IPC分类号： G01J9/00 ,  G02B9/64

摘要： Systems for inspecting a surface of an optical wave originating from an optical device are provided. The optical device includes an exit pupil, and the inspection system includes an optical measuring head and a computer for processing the images from said optical measuring head. The optical measuring head includes a density gradient filter, the density varying periodically in the two directions in space, a matrix frame having at least four identical lenses of square shape of the same focal length and being arranged symmetrically, and a photodetector array, each of the four lenses forming an image of the pupil in the plane of this array. The image processing computer includes computing means for computing the partial derivatives ∂ Δ ∂ x ⁢ ( x , y ) and ∂ Δ ∂ y ⁢ ( x , y ) of the wave surface Δ(x, y) in the plane of the exit pupil.

公开(公告)号：US20180203020A1

公开(公告)日：2018-07-19

申请号：US15742484

申请日：2016-07-08

申请人： CHU DE NICE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNR ,  UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS

发明人： Vincent Louis Marie Esnault ,  Barbara Polski ,  Gérard Jean Frantz Lambeau ,  Guillaume Dolla

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6878 ,  G01N2333/705 ,  G01N2800/347 ,  G01N2800/52

摘要： The invention relates to a method for assessing the prognosis of idiopathic membranous nephropathy in a subject, based on the analysis of PLA2R1 epitope profile. The invention further relates to a method for monitoring the progression of idiopathic membranous nephropathy based on the analysis of the PLA2R1 epitope spreading. The invention highlights that three PLA2R1 domains (Cys R, CTLD1 and CTLD7) are involved in anti-PLA2R1 activity, with two of them (CTLD1 and CTLD7) more closely associated with active idiopathic membranous nephropathy and likely linked by a mechanism of epitope spreading.

公开(公告)号：US09800399B2

公开(公告)日：2017-10-24

申请号：US14347739

申请日：2012-09-28

申请人： Centre National de la Recherche Scientifique—CNRS ,  Université de Nice Sophia Antipolis

发明人： Sébastien Tanzilli ,  Virginia D'Auria ,  Olivier Alibart ,  Anthony Christophe Mickaël Martin ,  Laurent Labonte

IPC分类号： H04B10/12 ,  H04L7/00 ,  H04L9/08 ,  H04B10/25 ,  H04B10/70

CPC分类号： H04L7/0075 ,  H04B10/25 ,  H04B10/70 ,  H04L9/0852

摘要： A device and a method for synchronizing entanglement sources with optical pump in a quantum communication network are disclosed. The device includes a pulsed optical source allowing emission of telecom wavelength optical clock pulses distributed in parallel to the entanglement sources to ensure synchronization of the entanglement sources; and for each of the entanglement sources, a frequency conversion device, allowing frequency conversion of the distributed telecom wavelength optical clock pulses to a wavelength adapted to optically pump the entanglement source. The method includes emitting and distributing in parallel, to the entanglement sources, telecom wavelength optical clock pulses; and locally, at each of the entanglement sources, frequency converting the telecom wavelength optical clock pulses to a wavelength adapted to optically pump the entanglement source.

公开(公告)号：US20170073762A1

公开(公告)日：2017-03-16

申请号：US15121864

申请日：2015-02-27

申请人： ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS ,  UNIVERSITÉ PARIS DIDEROT (PARIS VII) ,  UNIVERSITÉ DE NICE - SOPHIA ANTIPOLIS ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Johanna CHICHE ,  Catherine THIEBLEMONT ,  Jean-Ehrland RICCI

IPC分类号： C12Q1/68 ,  C07K16/30 ,  C07K16/28 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C07K16/2887 ,  C07K16/3061 ,  C07K2317/24 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5052 ,  G01N33/57426 ,  G01N2333/90203 ,  G01N2800/52

摘要： The present invention relates to a method for predicting the responsiveness of a patient to a treatment with an anti-CD20 antibody, said method comprising measuring the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in B cells obtained from said patient.

摘要翻译： 本发明涉及一种用于预测患者对抗CD20抗体治疗的反应性的方法，所述方法包括测量从所述患者获得的B细胞中甘油醛-3-磷酸脱氢酶（GAPDH）表达的水平。

公开(公告)号：US20190270771A1

公开(公告)日：2019-09-05

申请号：US16340832

申请日：2017-10-11

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ DE NICE - SOPHIA ANTIPOLIS

发明人： Jean MAZELLA ,  Marc BORSOTTO ,  Catherine HEURTEAUX ,  Alaeddine DJILLANI ,  Sébastien MORENO ,  Mariel PIETRI

IPC分类号： C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  A61K31/7105 ,  A61P25/24 ,  A61P25/08 ,  A61P35/00 ,  A61P3/10 ,  C12N15/63

摘要： Disclosed are new peptides derived from the neurotensin receptor 3 (NTSR3), and to their use, particularly in the treatment of various diseases, especially depression.