公开(公告)号：US20230296813A1

公开(公告)日：2023-09-21

申请号：US18018520

申请日：2020-07-30

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  OBSERVATOIRE DE LA COTE D’AZUR ,  UNIVERSITÉ CÔTE D’AZUR ,  UNIVERSITÉ GRENOBLE ALPES

发明人： François HENAULT ,  Alain SPANG

IPC分类号： G02B3/00 ,  G02B5/20 ,  G01J9/00

CPC分类号： G02B3/0056 ,  G01J9/00 ,  G02B5/20 ,  G02B2003/0093

摘要： The systems for inspecting an optical wave surface output from an optical device, the optical device comprising an output pupil, the inspection system comprising an optical measurement head and a computer for processing the images obtained from the optical measurement head. The optical measurement head comprises: a density gradient filter, the density varying periodically in the two directions of the space, a matrix array comprising at least four identical lenses, of square form, of the same focal length and disposed symmetrically, a matrix of photodetectors, each of the four lenses forming, of the pupil, an image in the plane of this matrix. The computer for processing the images comprises computation means that make it possible to calculate the partial derivatives






∂
Δ


∂
x




x
,
y


and


∂
Δ


∂
y




x
,
y






and of the wave surface Δ(x, y) in the plane of the output pupil.

公开(公告)号：US11754449B2

公开(公告)日：2023-09-12

申请号：US17310393

申请日：2020-01-21

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Observatoire De La Cote D'Azur ,  UNIVERSITE COTE D'AZUR ,  Université Grenoble Alpes

发明人： François Henault ,  Alain Spang

IPC分类号： G01J9/00 ,  G02B9/64

CPC分类号： G01J9/00 ,  G02B9/64

摘要： Systems for inspecting a surface of an optical wave originating from an optical device are provided. The optical device includes an exit pupil, and the inspection system includes an optical measuring head and a computer for processing the images from said optical measuring head. The optical measuring head includes a density gradient filter, the density varying periodically in the two directions in space, a matrix frame having at least four identical lenses of square shape of the same focal length and being arranged symmetrically, and a photodetector array, each of the four lenses forming an image of the pupil in the plane of this array. The image processing computer includes computing means for computing the partial derivatives






∂
Δ


∂
x


⁢

(

x
,
y

)






and







∂
Δ


∂
y


⁢

(

x
,
y

)





of the wave surface Δ(x, y) in the plane of the exit pupil.

公开(公告)号：US20220389019A1

公开(公告)日：2022-12-08

申请号：US17633617

申请日：2020-08-07

申请人： Université de Strasbourg ,  Centre National de la Recherche Scientifique ,  INSERM - Institut National de la Santé et de la Recherche Médicale ,  Université Grenoble Alpes

发明人： Didier ROGNAN ,  Martine SCHMITT ,  Maxime CAZORLA

IPC分类号： C07D487/04 ,  A61P25/28

摘要： The present invention relates to the field of pharmaceutical composition comprising “LIT-TB” derivatives. More particularly it relates to “LIT-TB” derivatives for use in the treatment of neurodegenerative diseases, and more particularly in the treatment of Huntington's disease. The invention also relates to the “LIT-TB” derivatives and preparation thereof.

公开(公告)号：US20220267417A1

公开(公告)日：2022-08-25

申请号：US17629161

申请日：2020-07-22

申请人： UNIVERSITÉ GRENOBLE ALPES ,  INSTITUT POLYTECHNIQUE DE GRENOBLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Jean-Luc LENORMAND ,  Landry GAYET ,  Géraldine MAYEUX

IPC分类号： C07K16/12 ,  A61P31/04 ,  G01N33/569

摘要： The invention relates to a monoclonal antibody against the OprF protein of Pseudomonas aeruginosa or to a functional fragment of this antibody. This antibody or antibody fragment is particularly useful for the preventive or curative treatment of infections with Pseudomonas aeruginosa.

公开(公告)号：US11387403B2

公开(公告)日：2022-07-12

申请号：US16628299

申请日：2018-07-05

申请人： UNIVERSITÉ GRENOBLE ALPES ,  VERMON S.A.

发明人： Libor Rufer ,  Skandar Basrour ,  Emilie Trioux ,  Guillaume Férin ,  Claire Bantignies ,  Hung Le Khanh ,  Bogdan Rosinski ,  An Nguyen-Dinh

IPC分类号： H01L41/09 ,  H01L41/113 ,  H01L41/083 ,  H01L41/27 ,  H02N2/18

摘要： A piezoelectric bimorph cantilever beam system includes a shim having a first main surface, a second main surface opposite the first main surface, a proximal end connected to an anchor, and a distal end opposite the proximal end. The system further includes a first piezoelectric layer laminated on the first main surface of the shim and a second piezoelectric layer laminated on the second main surface of the shim. A first beam stiffener is provided over the first main surface of the shim adjacent to the anchor with the first beam stiffener at least partially covering the first piezoelectric layer. A second beam stiffener is provided over the second main surface of the shim adjacent to the anchor with the second beam stiffener at least partially covering the second piezoelectric layer.

公开(公告)号：US11291406B2

公开(公告)日：2022-04-05

申请号：US16499827

申请日：2018-03-28

申请人： UNIVERSITÉ GRENOBLE ALPES

发明人： Damien Colas ,  Aurélien Bricout ,  Grégoire Gerard ,  Pierre-Yves Gumery

IPC分类号： A61B5/00 ,  A61B5/024

摘要： A system for determining a set of at least one cardio-respiratory descriptor of an individual during sleep comprises a memory device having a first accelerometer for a thoracic position, a second accelerometer synchronized with the first and for an abdominal position, and an optional sensor (e.g., a photoplethysmographic sensor). The system also includes memory for recording accelerometer and optional sensor data; memory with a reference model; and a device for filtering accelerometer data and configured to extract low-, medium-, and high- frequency ranges. A computer is configured for determining, within the extracted frequency ranges, at least one characteristic representative of a cardio-respiratory and physiological state and the time of the extraction thereof; comparing the determined characteristic(s) with similar characteristics from the reference model; and deducing therefrom a set of at least one probable corresponding event the individual experienced during a predetermined period of time.

公开(公告)号：US20210378995A1

公开(公告)日：2021-12-09

申请号：US17282428

申请日：2019-10-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE ROUEN NORMANDIE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN ,  UNIVERSITÉ GRENOBLE ALPES ,  CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE

发明人： Jérémy BELLIEN ,  Frédéric BOUNOURE ,  Mohamed SKIBA ,  Yann SAVINA ,  Matthieu ROUSTIT ,  Jean-Luc CRACOWSKI

IPC分类号： A61K31/17 ,  A61K31/197 ,  A61K31/4468 ,  A61K31/53 ,  A61P17/00 ,  A61P9/14 ,  A61P3/10

摘要： Microvascular dysfunction remains a major contributor to the development of skin complications. The inventors assessed the impact of the local inhibition of soluble epoxide hydrolase (sEH), which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on the diabetic skin microvascular dysfunction. The inventors have therefore developed some formulations of sEH inhibitors (GSK2256294 and t-AUCB) for topical administration. In particular, they show that an aqueous gel containing 400 mg/L t-AUCB dissolved in 50% dimethy lsulfo xide (DMSO) allowed a stable and continuous diffusion of t-AUCB from 2 hours after application on skin pig ears to over a period of 24 h. Compared to a control gel, the gel with t-AUCB did not significantly modify the basal skin blood flow but improved the altered hyperemic response of db/db mice 2 hours after application. The results show that the topical administration of a sEH inhibitor improves the skin microcirculatory function, representing a promising pharmacological approach to prevent the development of skin complications especially in diabetic patients.

公开(公告)号：US10978234B2

公开(公告)日：2021-04-13

申请号：US16277260

申请日：2019-02-15

申请人： Commissariat á l'énergie atomique et aux énergies alternatives ,  Université Grenoble Alpes ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Jyotirmoy Chatterjee ,  Paulo Veloso Coelho ,  Bernard Dieny ,  Ricardo Sousa ,  Lucian Prejbeanu

IPC分类号： G06F1/16 ,  H01L51/00 ,  G06F3/044 ,  G06F3/041 ,  H01L51/52 ,  H01L27/32 ,  H01F10/32 ,  H01L43/10 ,  H01L43/02 ,  H01L27/22 ,  G11C11/16 ,  G01R33/09 ,  H01F10/12 ,  H01F41/30 ,  H01L43/12

摘要： A magnetic stack includes a first element including a ferromagnetic layer; a second element including a metal layer able to confer on the assembly formed by the first and the second elements a magnetic anisotropy perpendicular to the plane of the layers. The first element further includes a refractory metal material, the second element being arranged on the first element.

公开(公告)号：US10968436B2

公开(公告)日：2021-04-06

申请号：US16716202

申请日：2019-12-16

申请人： Université Grenoble Alpes ,  Centre National de la Recherche Scientifique

发明人： Jérôme Dupuy

IPC分类号： C12N9/00 ,  C12Q1/26 ,  C12Q1/28 ,  G01N33/52 ,  C12N9/02

摘要： The present invention relates to novel NADPH oxidase proteins, or Nox, the use thereof, the method of preparation thereof and the method for identification thereof.

公开(公告)号：US20210036210A1

公开(公告)日：2021-02-04

申请号：US17047669

申请日：2019-04-11

申请人： Consiglio Nazionale Delle Ricerche ,  ENEA - AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE ,  Université Grenoble Alpes

发明人： Riccardo Castagna ,  Massimo Rippa ,  Lucia Petti ,  Anna De Girolamo Del Mauro ,  Giuseppe Nenna ,  Claudia Diletto ,  Gustavo Ardila Rodriguez

IPC分类号： H01L41/08 ,  H01L41/193 ,  H01L41/047 ,  H01L41/297 ,  H01L41/37 ,  H01L41/45 ,  H01L41/314

摘要： The present invention relates to a energy conversion device (100) configured to convert a light signal into an electrical signal, comprising: an actuator element (50), substantially planar, having at least one activatable portion (30), said activatable portion comprising a photomobile polymeric material; a transducer element (60), substantially planar, having at least a portion of piezoelectric material; wherein said actuator element (50) is coupled to said transducer element (60) so that, at a light beam incident on said photomobile polymeric material, a movement of said transducer element (60) is activated through a movement of said activatable portion (30), said movement of said transducer element (60) providing the generation of a potential difference at the terminal ends of said portion of piezoelectric material.
The present invention also relates to a method of production of the aforesaid device.