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1.发明公开公开(公告)号：US20240116923A1
公开(公告)日：2024-04-11
申请号：US18273878
申请日：2022-01-25
申请人： Seabelife , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , Université Claude Bernard Lyon 1 , Universite de Rennes 1
发明人： Stéphane BACH , Arnaud COMTE , Claire DELEHOUZE , Marie-Thérèse DIMANCHE-BOITREL , Peter GOEKJIAN
IPC分类号： C07D471/04 , A61K31/404 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P39/06 , C07D209/12
CPC分类号： C07D471/04 , A61K31/404 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P39/06 , C07D209/12
摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.
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公开(公告)号：US20240116876A1
公开(公告)日：2024-04-11
申请号：US17925738
申请日：2021-05-19
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Universite de Bretagne Occidentale , Ecole Nationale Superieure de Chimie de Rennes , Institut National des Sciences Appliquees de Rennes , Universite Nangui Abrogoua , Centre National de la Recherche Scientifique , Universite de Rennes 1
发明人： Jean Pierre Bazureau , Déliko Camille Dago , Lou Anna Voli , Olivier Mignen , Christophe Brigaudeau , Yves-Alain Berko
IPC分类号： C07D235/04 , A61P35/00
CPC分类号： C07D235/04 , A61P35/00
摘要： The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.
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公开(公告)号：US11834429B2
公开(公告)日：2023-12-05
申请号：US17058197
申请日：2019-05-29
发明人： Guillaume Michaud , Stéphane Fouquay , Frédéric Simon , Cyril Chauveau , Sophie Guillaume , Jean-François Carpentier
IPC分类号： C07D317/40 , C08F212/08 , C08F220/14 , C08F220/28 , C08F220/18
CPC分类号： C07D317/40 , C08F212/08 , C08F220/14 , C08F220/283 , C08F220/1804 , C08F220/1811 , C08F220/40 , C08F212/08 , C08F220/1804 , C08F220/1811 , C08F220/14 , C08F212/08 , C08F220/1811 , C08F220/1804 , C08F220/14
摘要： The invention relates to a monoethylenically unsaturated monomer of formula (I), and to the use thereof for producing a polymer. The invention also relates to the polymer obtained by polymerising said monomer, and to the use thereof in a composition for producing coatings.
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公开(公告)号：US20220315517A1
公开(公告)日：2022-10-06
申请号：US17642248
申请日：2020-09-14
申请人： DEMETA , UNIVERSITE DE RENNES 1
摘要： The present invention relates to a method for oxidative cleavage of a substrate consisting of at least one functionalised or non-functionalised linear olefin, in particular a mono- or polyunsaturated aliphatic carboxylic acid, or one of the esters thereof, or at least one non-functionalised cyclic olefin, using hydrogen peroxide, in the presence of a metal catalyst which consists of at least one onium halooxodiperoxometallate. It also relates to a novel catalyst consisting of a specific onium halooxodiperoxometallate which can be used, in particular, in said method.
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公开(公告)号：US11345184B2
公开(公告)日：2022-05-31
申请号：US16480465
申请日：2018-01-26
摘要： A solvent transfer printing method for applying a pattern made of a non-soluble material and non-dispersible on the surface of an object. The method includes the steps of: m1/forming a pattern on a surface of a solvent-soluble substrate, m2/depositing the solvent-soluble substrate on the surface of a solvent bath, on the side of the substrate opposed to the side on which the pattern is applied, in order to dissolve partially the substrate, m3/dipping the object in the bath, so that the surface of the object comes into contact with the pattern, m4/getting the object, on which the pattern is applied, out of the bath, and b 5/drying the object.
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6.发明授权公开(公告)号：US11171250B2
公开(公告)日：2021-11-09
申请号：US16305579
申请日：2017-05-22
申请人： SAFRAN ELECTRONICS & DEFENSE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS- , UNIVERSITE DE RENNES 1
IPC分类号： H01L31/00 , H01L31/0216 , H01L31/0203 , H01L31/18
摘要： A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.
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公开(公告)号：US11114761B2
公开(公告)日：2021-09-07
申请号：US16652564
申请日：2018-10-04
申请人： TDF , UNIVERSITE DE RENNES 1
摘要： The invention concerns an antenna, comprising at least two non-ferrous metal plates, at least one first plate forming a radiating portion and a second plate forming a mass plane, at least one substrate, arranged between the mass plane and the radiating portion, and an excitor of length at least equal to the thickness of the substrate, extending between the mass plane and the radiating portion and connected to the radiating portion, and adapted to supply the antenna, characterised in that the substrate is a dispersive ferromagnetic substrate, called dispersive ferrite presenting, as magnetic features, a high relative magnetic permeability comprised between 10 and 10,000 and a high magnetic loss tangent greater than 0.1, said antenna comprising means for gradually and locally reducing magnetic features of the dispersive ferrite.
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公开(公告)号：US20210207151A1
公开(公告)日：2021-07-08
申请号：US17056574
申请日：2018-05-25
发明人： Reynald GILLET , Charlotte GUYOMAR
摘要： The present invention relates to a reporter system for trans-translation based on the reassembly of GFP and on the capacity of tmRNA to add a peptide tag to a protein blocked on a ribosome. The invention also relates to the in vivo or in vitro use of this reporter system for studying trans-translational activity and for identifying compounds capable of inhibiting trans-translation and therefore capable of being of interest as antibiotics.
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公开(公告)号：US20210163671A1
公开(公告)日：2021-06-03
申请号：US17263475
申请日：2019-07-19
发明人： Frederic SIMON , Stephane FOUQUAY , Guillaume MICHAUD , Cyril CHAUVEAU , Jean-Francois CARPENTIER , Sophie GUILLAUME
摘要： Method for preparing a compound having an alkoxysilyl group of formula (I), wherein X represents —O— or —NR4— with R4═H or C1-C4alkyl; R1 is a radical having from 1 to 20 carbon atoms; R2 and R3 are a C1-C4 alkyl radical; p is an integer equal to 0, 1 or 2; comprising a cross metathesis reaction in the presence (i) of a compound having a group of acrylate type and of formula: —X(C═O)—CH═CH2, (ii) of an α-olefinic silane of formula (II): and (iii) of a metathesis catalyst chosen from GRUBBS catalysts and 2nd generation HOVEYDA-GRUBBS (HG2) catalysts. 2) Compound having said alkoxysilyl group, obtained by the method 1).
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公开(公告)号：US10739392B2
公开(公告)日：2020-08-11
申请号：US15747217
申请日：2016-07-20
发明人： Maxim Zhadobov , Artem Boriskin
IPC分类号： G01R29/08
摘要： Some embodiments relate to a device for simulating characteristics of human tissues in electromagnetic dosimetry. The device includes a substrate bearing a metallised shielding, a layer of a dielectric material arranged on or preferentially beneath the substrate and the device including a plurality of openings made in the shielding and at least one array of sensors in the layer of dielectric material.
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