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1.发明授权公开(公告)号：US09388252B2
公开(公告)日：2016-07-12
申请号：US14624294
申请日：2015-02-17
IPC分类号： A61K38/18 , C08B37/00 , A61K31/7016 , A61K6/097 , A61K9/06 , C08J3/075 , C08L5/12 , A61K47/36 , A61L27/20 , A61L27/52 , A61L15/60 , A61K31/729 , A61K9/00
CPC分类号： C08B37/0039 , A61K6/097 , A61K9/0019 , A61K9/06 , A61K31/7016 , A61K31/729 , A61K38/18 , A61K47/36 , A61L15/28 , A61L15/60 , A61L26/0023 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/04 , C08B37/0003 , C08J3/075 , C08J2305/12 , C08L5/12 , C08L1/00
摘要： Methods for removing endotoxin from naturally occurring materials, such as polysaccharides (e.g., agarose and/or carrageenan) are described herein. Polysaccharides that are substantially free of endotoxins and uses thereof are also described. The polysaccharide materials can be isolated from microorganisms, multicellular organisms, such as, algae, plants, seaweed, etc. The method involves the use of acidic and basic solutions to hydrolyze the lipid-polysaccharide bond in endotoxins. Cleaving the fatty acid from the polysaccharide reduces the water-solubility of the fatty acid and enables its removal with an organic solvent such as ethanol. The polysaccharide component can also undergo acidic or basic hydrolysis due to the weak glycosidic bond between the sugar rings.
摘要翻译： 本文描述了从天然存在的材料如多糖（例如琼脂糖和/或角叉菜胶）中除去内毒素的方法。 还描述了基本上不含内毒素的多糖及其用途。 多糖物质可以从微生物，多细胞生物体，如藻类，植物，海藻等中分离。该方法包括使用酸性和碱性溶液来水解内毒素中的脂多糖键。 从多糖中切下脂肪酸降低了脂肪酸的水溶性，使其能够用有机溶剂如乙醇除去。 由于糖环之间的弱糖基键，多糖组分也可以进行酸性或碱性水解。
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2.发明申请METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT 审中-公开从光聚合环境中保护敏感分子的方法公开(公告)号：US20100009914A1
公开(公告)日：2010-01-14
申请号：US12496680
申请日：2009-07-02
CPC分类号： A61K48/0008 , A61K9/0024 , A61K9/2077 , A61K9/2095 , A61K47/32 , A61K48/0041 , A61K48/0091
摘要： In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photo-polymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules.
摘要翻译： 在一个实施方案中，本发明是可光聚合单体和生物活性分子的底物体系，其与单体混合，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽。 在聚合时，单体产生交联结构，并且保护的生物活性分子免受聚合环境的侵袭。 在不同方面，底物系统用于药物递送和组织工程和酶，蛋白质和生长因子的保护。 在另一个实施方案中，本发明是可光聚合单体的药物递送系统，与单体相关的药物分子，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽，以及用于聚合的光聚合装置 所述单体产生包括药物分子的交联结构。
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3.发明申请Methods for Purifying Polysaccharides and Pharmaceutical Compositions and Medical Devices Containing the Same 审中-公开纯化多糖和药物组合物的方法及其含有的医疗装置公开(公告)号：US20170002099A1
公开(公告)日：2017-01-05
申请号：US15183077
申请日：2016-06-15
IPC分类号： C08B37/00 , A61K9/06 , A61K38/18 , A61K6/097 , C08J3/075 , A61L26/00 , A61L27/20 , A61L27/52 , A61L31/14 , A61L31/04 , A61K47/36 , A61L15/28
CPC分类号： C08B37/0039 , A61K6/097 , A61K9/0019 , A61K9/06 , A61K31/7016 , A61K31/729 , A61K38/18 , A61K47/36 , A61L15/28 , A61L15/60 , A61L26/0023 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/04 , C08B37/0003 , C08J3/075 , C08J2305/12 , C08L5/12 , C08L1/00
摘要： Methods for removing endotoxin from naturally occurring materials, such as polysaccharides (e.g., agarose and/or carrageenan) are described herein. Polysaccharides that are substantially free of endotoxins and uses thereof are also described. The polysaccharide materials can be isolated from microorganisms, multicellular organisms, such as, algae, plants, seaweed, etc. The method involves the use of acidic and basic solutions to hydrolyze the lipid-polysaccharide bond in endotoxins. Cleaving the fatty acid from the polysaccharide reduces the water-solubility of the fatty acid and enables its removal with an organic solvent such as ethanol. The polysaccharide component can also undergo acidic or basic hydrolysis due to the weak glycosidic bond between the sugar rings.
摘要翻译： 本文描述了从天然存在的材料如多糖（例如琼脂糖和/或角叉菜胶）中除去内毒素的方法。 还描述了基本上不含内毒素的多糖及其用途。 多糖物质可以从微生物，多细胞生物体，如藻类，植物，海藻等中分离。该方法包括使用酸性和碱性溶液来水解内毒素中的脂多糖键。 从多糖中切下脂肪酸降低了脂肪酸的水溶性，使其能够用有机溶剂如乙醇除去。 由于糖环之间的弱糖基键，多糖组分也可以进行酸性或碱性水解。
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4.发明申请公开(公告)号：US20150232581A1
公开(公告)日：2015-08-20
申请号：US14624294
申请日：2015-02-17
IPC分类号： C08B37/00 , A61K9/06 , A61K6/097 , A61K31/7016 , A61K45/06
CPC分类号： C08B37/0039 , A61K6/097 , A61K9/0019 , A61K9/06 , A61K31/7016 , A61K31/729 , A61K38/18 , A61K47/36 , A61L15/28 , A61L15/60 , A61L26/0023 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , A61L2400/04 , C08B37/0003 , C08J3/075 , C08J2305/12 , C08L5/12 , C08L1/00
摘要： Methods for removing endotoxin from naturally occurring materials, such as polysaccharides (e.g., agarose and/or carrageenan) are described herein. Polysaccharides that are substantially free of endotoxins and uses thereof are also described. The polysaccharide materials can be isolated from microorganisms, multicellular organisms, such as, algae, plants, seaweed, etc. The method involves the use of acidic and basic solutions to hydrolyze the lipid-polysaccharide bond in endotoxins. Cleaving the fatty acid from the polysaccharide reduces the water-solubility of the fatty acid and enables its removal with an organic solvent such as ethanol. The polysaccharide component can also undergo acidic or basic hydrolysis due to the weak glycosidic bond between the sugar rings.
摘要翻译： 本文描述了从天然存在的材料如多糖（例如琼脂糖和/或角叉菜胶）中除去内毒素的方法。 还描述了基本上不含内毒素的多糖及其用途。 多糖物质可以从微生物，多细胞生物体，如藻类，植物，海藻等中分离。该方法包括使用酸性和碱性溶液来水解内毒素中的脂多糖键。 从多糖中切下脂肪酸降低了脂肪酸的水溶性，使其能够用有机溶剂如乙醇除去。 由于糖环之间的弱糖基键，多糖组分也可以进行酸性或碱性水解。
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公开(公告)号：US07291693B2
公开(公告)日：2007-11-06
申请号：US10180000
申请日：2002-06-25
IPC分类号： C08G73/06
CPC分类号： H01B1/127 , C08G61/124
摘要： The present invention specifically contemplates a polymer, preferably an electrically conductive polymer, derived from substituted pyrrolyl moieties.
摘要翻译： 本发明具体考虑了衍生自取代的吡咯基部分的聚合物，优选导电聚合物。
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