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    NEW ENAMEL-DENTIN ADHESIVES BASED ON CHEMICALLY MODIFIED NATURAL POLYSACCHARIDES
    1.
    发明申请
    NEW ENAMEL-DENTIN ADHESIVES BASED ON CHEMICALLY MODIFIED NATURAL POLYSACCHARIDES 有权
    基于化学修饰的天然多糖的新型ENAMEL-DENTIN粘合剂

    公开(公告)号：US20160362503A1

    公开(公告)日：2016-12-15

    申请号：US15121504

    申请日：2015-02-26

    申请人： Universita' Degli Studi Di Trieste

    发明人： Sergio Paoletti ,  Roberto Di Lenarda ,  Lorenzo Breschi ,  Milena Cadenaro ,  Marina Diolosa ,  Gianluca Turco ,  Ivan Donati

    IPC分类号： C08B37/08 ,  A61L24/08 ,  A61K6/097

    CPC分类号： C08B37/003 ,  A61K6/083 ,  A61K6/097 ,  A61L24/08 ,  C08L33/08 ,  C08L5/08

    摘要： The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

    摘要翻译： 本发明涉及具有丙烯酸基团的壳聚糖的化学改性衍生物的制备及其在釉 - 牙本质粘合剂领域中的应用。 壳聚糖衍生物具有物理化学特征（亲水性，在链上存在电荷），这使得它们与去矿质化牙齿的有机部分相互作用。 同时，掺入聚合物链中的丙烯酸基允许与通常由丙烯酸树脂组成的牙科领域中使用的修复材料形成共价键。 通过结合与牙齿表面的粘附和与修复材料的粘合，本文所述的化学改性的壳聚糖能够增加牙齿修复体的寿命，因此可用于粘合剂领域，特别是牙釉质 - 牙本质粘合剂领域。

    Light-curable bone growth material for treating dental bone defects
    5.
    发明申请
    Light-curable bone growth material for treating dental bone defects 审中-公开
    用于治疗牙齿缺陷的可光固化骨生长材料

    公开(公告)号：US20100034883A1

    公开(公告)日：2010-02-11

    申请号：US12587717

    申请日：2009-10-12

    申请人： Katherine Suzanne Walline ,  Brent Lee Atkinson

    发明人： Katherine Suzanne Walline ,  Brent Lee Atkinson

    IPC分类号： A61K9/14 ,  A61P19/08

    CPC分类号： A61K6/087 ,  A61K6/0052 ,  A61K6/097 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/44 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/02 ,  C08L5/08 ,  C08L1/284

    摘要： Improved compositions comprising a mixture of particulate bone growth material and polymeric carrier are provided. The particulate is preferably porous, resorbable, anorganic bone material. The polymeric carrier can be light-cured to form a cross-linked, biodegradable hydrogel. In one version, the bone growth material is a synthetic peptide bound to anorganic bone matrix particles and the carrier is methacrylated sodium hyaluronate (MHy) or methacrylated hydroxyethylcellulose (MHEC). The composition is particularly suitable for repairing defective dental and orthopedic bone tissue. The particulate and hydrogel carrier are biodegradable so the composition can be replaced by new bone formation over time.

    摘要翻译： 提供包含颗粒骨生长材料和聚合物载体的混合物的改进的组合物。 颗粒优选是多孔的，可再吸收的，无机骨材料。 聚合物载体可以光固化形成交联的可生物降解的水凝胶。 在一个版本中，骨生长材料是与无机骨基质颗粒结合的合成肽，载体是甲基丙烯酸化的透明质酸钠（MHy）或甲基丙烯酸羟乙基纤维素（MHEC）。 该组合物特别适用于修复有缺陷的牙科和矫形骨组织。 颗粒和水凝胶载体是可生物降解的，因此随着时间的推移，组合物可以被新的骨形成代替。

    Organometallic monoacylarylphosphines
    8.
    发明授权
    Organometallic monoacylarylphosphines 失效
    有机金属一酰基芳基膦

    公开(公告)号：US06399805B2

    公开(公告)日：2002-06-04

    申请号：US09776657

    申请日：2001-02-05

    申请人： Jean-Pierre Wolf ,  Beat Michael Aebli ,  Gebhard Hug

    发明人： Jean-Pierre Wolf ,  Beat Michael Aebli ,  Gebhard Hug

    IPC分类号： C07F953

    CPC分类号： C09D11/101 ,  A61K6/0052 ,  A61K6/08 ,  B33Y70/00 ,  C07F9/28 ,  C07F9/5036 ,  C07F9/5337 ,  C07F9/6521 ,  C08F2/50 ,  C09D4/00 ,  G03F7/0045 ,  G03F7/029 ,  G03F7/0384 ,  G03F7/0388 ,  G03F7/0755 ,  Y10S430/124 ,  A61K6/083 ,  C08L33/08 ,  C08L33/10 ,  C08L33/20 ,  C08L33/26 ,  C08L27/00 ,  C08L31/04 ,  C08L25/06 ,  C08L27/04 ,  C08L39/06 ,  A61K6/09 ,  C08L75/04 ,  A61K6/087 ,  C08L67/00 ,  C08L71/02 ,  A61K6/097 ,  C08L1/08

    摘要： Compounds of the formula I R1 and R2 independently of one another are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 independently of one another are hydrogen, C1-C20alkyl, OR1 or halogen; R6, R7, R8, R9 and R10 independently of one another are hydrogen, C1-C20alkyl; C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R6, R7, R8, R9 and R10 are OR11, SR11, N(R12)(R13), phenyl or halogen; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; R12 and R13 independently of one another are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R12 and R13 together are C3-C5alkylene which can be interrupted by O, S or NR14; R14 is hydrogen, phenyl, C1-C12alkyl or C2-C12alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; and M is hydrogen, Li, Na or K; are valuable intermediates for the preparation of unsymmetrical bisacylphosphine oxides and monoacylphosphine oxides.

    摘要翻译： 式IR1和R2的化合物彼此独立地为C1-C20烷基，OR11，CF3或卤素; R 3，R 4和R 5彼此独立地是氢，C 1 -C 20烷基，OR 1或卤素; R 6，R 7，R 8，R 9和R 10彼此独立地是氢，C 1 -C 20烷基; 被不连续的O原子中断一次或多于一次且未被取代或被OH和/或SH取代的C 2 -C 20烷基; 或R 6，R 7，R 8，R 9和R 10为OR 11，SR 11，N（R 12）（R 13），苯基或卤素; R 11是被O或S间隔一次或多于一次并且未被取代或被OH和/或SH取代的C 1 -C 20烷基，C 3 -C 8环烷基，苯基，苄基或C 2 -C 20烷基。 R 12和R 13彼此独立地是氢，C 1 -C 20烷基，C 3 -C 8环烷基，苯基，苄基或C 2 -C 20烷基，其被非连续的O原子中断一次或多于一次，并且是未取代的或被OH和/或SH取代; 或R 12和R 13一起是可被O，S或NR14中断的C 3 -C 5亚烷基; R 14是氢，苯基，C 1 -C 12烷基或C 2 -C 12烷基，其被O或S间隔一次或多于一次，并且是未取代的或被OH和/或SH取代; M为氢，Li，Na或K; 是制备不对称双酰基氧化膦和单酰基氧化膦的有价值的中间体。

    Calcium phosphate cements prepared from silicate solutions
    9.
    发明授权
    Calcium phosphate cements prepared from silicate solutions 有权
    由硅酸盐溶液制备的磷酸钙水泥

    公开(公告)号：US06375935B1

    公开(公告)日：2002-04-23

    申请号：US09561324

    申请日：2000-04-28

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K716

    CPC分类号： A61L24/02 ,  A61K6/0612 ,  A61K6/0643 ,  A61K6/097 ,  A61L27/12 ,  Y10S514/951 ,  Y10S514/953 ,  A61K6/087 ,  C08L89/00

    摘要： Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.

    摘要翻译： 提供生产可流动组合物的方法，例如 糊剂，即磷酸钙产品。 在本发明的方法中，将包含钙源和磷酸盐源的干燥反应物与可溶性硅酸盐的溶液合并。 并将混合的液体和固体混合以产生可流动的组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如， 骨缺损。

    Organometallic monoacylarylphosphines
    10.
    发明申请
    Organometallic monoacylarylphosphines 失效
    有机金属一酰基芳基膦

    公开(公告)号：US20010031898A1

    公开(公告)日：2001-10-18

    申请号：US09776657

    申请日：2001-02-05

    发明人： Jean-Pierre Wolf ,  Beat Michael Aebli ,  Gebhard Hug

    IPC分类号： C07F009/576 ,  C07F009/28 ,  C07F009/572

    CPC分类号： C09D11/101 ,  A61K6/0052 ,  A61K6/08 ,  B33Y70/00 ,  C07F9/28 ,  C07F9/5036 ,  C07F9/5337 ,  C07F9/6521 ,  C08F2/50 ,  C09D4/00 ,  G03F7/0045 ,  G03F7/029 ,  G03F7/0384 ,  G03F7/0388 ,  G03F7/0755 ,  Y10S430/124 ,  A61K6/083 ,  C08L33/08 ,  C08L33/10 ,  C08L33/20 ,  C08L33/26 ,  C08L27/00 ,  C08L31/04 ,  C08L25/06 ,  C08L27/04 ,  C08L39/06 ,  A61K6/09 ,  C08L75/04 ,  A61K6/087 ,  C08L67/00 ,  C08L71/02 ,  A61K6/097 ,  C08L1/08

    摘要： 1 R1 and R2 independently of one another are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 independently of one another are hydrogen, C-C20alkyl, OR11 or halogen; R6, R7, R8, R9 and R10 independently of one another are hydrogen, C1-C20alkyl; C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R6, R7, R8, R9 and R10 are OR11, SR11, N(R12)(R13), phenyl or halogen; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; R12 and R13 independently of one another are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R12 and R13 together are C3-C5alkylene which can be interrupted by O, S or NR14; R14 is hydrogen, phenyl, C1-C12alkyl or C2-C12alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; and M is hydrogen, Li, Na or K; are valuable intermediates for the preparation of unsymmetrical bisacylphosphine oxides and monoacylphosphine oxides.

    摘要翻译： R 1和R 2彼此独立地是C 1 -C 20烷基，OR 11，CF 3或卤素; R 3，R 4和R 5彼此独立地是氢，C 1 -C 20烷基，OR 11或卤素; R 6，R 7，R 8，R 9和R 10彼此独立地是氢，C 1 -C 20烷基; 被不连续的O原子中断一次或多于一次且未被取代或被OH和/或SH取代的C 2 -C 20烷基; 或R 6，R 7，R 8，R 9和R 10为OR 11，SR 11，N（R 12）（R 13），苯基或卤素; R 11是被O或S间隔一次或多于一次并且未被取代或被OH和/或SH取代的C 1 -C 20烷基，C 3 -C 8环烷基，苯基，苄基或C 2 -C 20烷基。 R 12和R 13彼此独立地是氢，C 1 -C 20烷基，C 3 -C 8环烷基，苯基，苄基或C 2 -C 20烷基，其被非连续的O原子中断一次或多于一次，并且是未取代的或被OH和/或SH取代; 或R 12和R 13一起是可被O，S或NR14中断的C 3 -C 5亚烷基; R 14是氢，苯基，C 1 -C 12烷基或C 2 -C 12烷基，其被O或S间隔一次或多于一次，并且是未取代的或被OH和/或SH取代; M为氢，Li，Na或K; 是制备不对称双酰基氧化膦和单酰基氧化膦的有价值的中间体