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公开(公告)号：US08546432B2
公开(公告)日：2013-10-01
申请号：US13101978
申请日：2011-05-05
申请人： Adilah Bahadoor , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Adilah Bahadoor , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： A61K31/41 , A61K31/4184 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/7056 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D257/04 , C07D295/185 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/421 , Y02A50/422 , Y02A50/423 , Y02A50/478 , Y02A50/491 , Y02A50/492
摘要： Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
摘要翻译： 本文提供式（I）的四唑酮FASN抑制剂：或其药学上可接受的形式; 其中变量RA，RB和RC在本文中定义。 本文还提供本文提供的化合物的药物组合物及其用于治疗各种疾病如过度增殖性疾病，炎症性疾病，肥胖相关病症和微生物感染的方法。
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公开(公告)号：US08450350B2
公开(公告)日：2013-05-28
申请号：US13101970
申请日：2011-05-05
申请人： Adilah Bahadoor , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Thomas T. Tibbitts
发明人： Adilah Bahadoor , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Thomas T. Tibbitts
IPC分类号： A61K31/41 , A61K31/4192 , C07D249/00 , C07D249/06
CPC分类号： A61K31/4192 , A61K31/454 , A61K31/4709 , A61K45/06 , C07D249/04 , C07D249/06 , C07D249/18 , C07D401/06 , C07D401/12 , C07D471/04
摘要： Provided herein are triazole FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, X, RB, and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
摘要翻译： 本文提供式（I）的三唑FASN抑制剂：或其药学上可接受的形式; 其中变量RA，X，RB和RC在本文中定义。 本文还提供本文提供的化合物的药物组合物及其用于治疗各种疾病如过度增殖性疾病，炎症性疾病，肥胖相关病症和微生物感染的方法。
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公开(公告)号：US20110274655A1
公开(公告)日：2011-11-10
申请号：US13101978
申请日：2011-05-05
申请人： Adilah BAHADOOR , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Adilah BAHADOOR , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/41 , C07D417/10 , C07D403/10 , C07D401/06 , C07D401/12 , C07D413/12 , C07D417/06 , A61K31/433 , A61K31/454 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K38/21 , A61K31/7056 , A61P33/02 , A61P33/06 , A61P33/00 , A61P31/10 , A61P31/04 , A61P31/12 , A61P31/16 , A61P29/00 , A61P3/04 , A61P3/10 , A61P1/16 , C07D257/04
CPC分类号： A61K31/41 , A61K31/4184 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/7056 , A61K38/21 , A61K38/212 , A61K38/217 , A61K45/06 , C07D257/04 , C07D295/185 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/421 , Y02A50/422 , Y02A50/423 , Y02A50/478 , Y02A50/491 , Y02A50/492
摘要： Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein.Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
摘要翻译： 本文提供式（I）的四唑酮FASN抑制剂：或其药学上可接受的形式; 其中变量RA，RB和RC在本文中定义。 本文还提供本文提供的化合物的药物组合物及其用于治疗各种疾病如过度增殖性疾病，炎症性疾病，肥胖相关病症和微生物感染的方法。
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公开(公告)号：US20110274654A1
公开(公告)日：2011-11-10
申请号：US13101970
申请日：2011-05-05
申请人： Adilah BAHADOOR , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Thomas T. Tibbitts
发明人： Adilah BAHADOOR , Alfredo C. Castro , Lawrence K. Chan , Gregg F. Keaney , Marta Nevalainen , Vesa Nevalainen , Stephane Peluso , Thomas T. Tibbitts
IPC分类号： A61K38/21 , C07D249/04 , A61K31/4709 , A61K31/454 , A61K31/4192 , A61K31/7056 , A61P31/04 , A61P31/10 , A61P31/06 , A61P33/00 , A61P33/02 , A61P33/12 , A61P33/10 , A61P33/04 , A61P33/06 , C07D401/06
CPC分类号： A61K31/4192 , A61K31/454 , A61K31/4709 , A61K45/06 , C07D249/04 , C07D249/06 , C07D249/18 , C07D401/06 , C07D401/12 , C07D471/04
摘要： Provided herein are triazole FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, X, RB, and RC are defined herein.Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.
摘要翻译： 本文提供式（I）的三唑FASN抑制剂：或其药学上可接受的形式; 其中变量RA，X，RB和RC在本文中定义。 本文还提供本文提供的化合物的药物组合物及其用于治疗各种疾病如过度增殖性疾病，炎症性疾病，肥胖相关病症和微生物感染的方法。
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