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公开(公告)号:US20060252724A1
公开(公告)日:2006-11-09
申请号:US11486532
申请日:2006-07-14
申请人: Karen Lyons , Vicki Rosen , Aaron Daluiski , Thomas Engstrand , Matthew Bahamonde , Laura Gamer , Eric Agius , Karen Cox
发明人: Karen Lyons , Vicki Rosen , Aaron Daluiski , Thomas Engstrand , Matthew Bahamonde , Laura Gamer , Eric Agius , Karen Cox
IPC分类号: A61K48/00 , A61K39/395
CPC分类号: C07K14/51 , A61K38/00 , C12N2799/027
摘要: Methods and compositions are provided for the treatment of defects and disease involving osteoporosis or osteopenic conditions. The methods comprise applying to the site of osteoporotic or osteopenic conditions a composition comprising a BMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utlizing BMP-3 conditions.
摘要翻译: 提供了用于治疗涉及骨质疏松症或骨质疏松症的缺陷和疾病的方法和组合物。 所述方法包括将包含BMP-3抑制剂或拮抗剂的组合物应用于骨质疏松或骨质疏松症状的部位。 本发明还提供了调节或调节BMP-3骨形成条件的方法和组合物。
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公开(公告)号:US5618924A
公开(公告)日:1997-04-08
申请号:US655579
申请日:1991-03-18
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N1/21 , C12N15/12 , C07K14/435 , C12N15/00
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2蛋白质及其制备方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5108922A
公开(公告)日:1992-04-28
申请号:US561496
申请日:1990-07-31
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-1 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-1蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5013649A
公开(公告)日:1991-05-07
申请号:US179100
申请日:1988-04-08
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US20070026437A1
公开(公告)日:2007-02-01
申请号:US11472281
申请日:2006-06-22
申请人: Elizabeth Wang , John Wozney , Vicki Rosen
发明人: Elizabeth Wang , John Wozney , Vicki Rosen
IPC分类号: C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/475
CPC分类号: A61L27/227 , A61K38/00 , C07K14/51
摘要: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2和BMP-4蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US20070004005A1
公开(公告)日:2007-01-04
申请号:US11154826
申请日:2005-06-17
申请人: Anthony Celeste , John Wozney , Vicki Rosen , Neil Wolfman , Gerald Thomsen , Douglas Melton
发明人: Anthony Celeste , John Wozney , Vicki Rosen , Neil Wolfman , Gerald Thomsen , Douglas Melton
IPC分类号: A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译: 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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公开(公告)号:US5116738A
公开(公告)日:1992-05-26
申请号:US692827
申请日:1991-04-26
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-3蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US06432919B1
公开(公告)日:2002-08-13
申请号:US07655578
申请日:1991-03-04
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
IPC分类号: A61K3816
CPC分类号: C07K14/51 , A61K38/00 , A61L24/043 , A61L27/227 , C08L89/00
摘要: Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-3蛋白质及其生产方法。 它们可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US4877864A
公开(公告)日:1989-10-31
申请号:US31346
申请日:1987-03-26
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
CPC分类号: C07K14/51 , A61K35/32 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Human and bovine bone inductive factors are provided. Such factors may be produced by recombinant techniques and be useful in the treatment of bone defects.
摘要翻译: 提供了人骨和牛骨诱导因子。 这些因素可以通过重组技术产生并且可用于治疗骨缺损。
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公开(公告)号:US20050159348A9
公开(公告)日:2005-07-21
申请号:US10397214
申请日:2003-03-27
申请人: Elizabeth Wang , John Wozney , Vicki Rosen
发明人: Elizabeth Wang , John Wozney , Vicki Rosen
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/12 , C12N15/18 , A61K38/17 , C07K14/47
CPC分类号: A61L27/227 , A61K38/00 , A61L24/043 , C07K14/51 , Y10S514/801 , Y10S514/90 , Y10S930/12 , C08L89/00
摘要: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2和BMP-4蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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