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    CARBOHYDRATE BASED TOLL-LIKE RECEPTOR (TLR) ANTAGONISTS
    1.
    发明申请
    CARBOHYDRATE BASED TOLL-LIKE RECEPTOR (TLR) ANTAGONISTS 审中-公开
    基于碳氢化合物的类似受体（TLR）拮抗剂

    公开(公告)号：US20090215710A1

    公开(公告)日：2009-08-27

    申请号：US12236358

    申请日：2008-09-23

    申请人： Shakti Upadhyay ,  Ashwani Sharma ,  Anuradha Sharma ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

    发明人： Shakti Upadhyay ,  Ashwani Sharma ,  Anuradha Sharma ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

    IPC分类号： A61K31/7028 ,  C07H5/06 ,  C12N5/06 ,  C12Q1/02

    CPC分类号： C07H5/04 ,  C07H15/06 ,  C07H15/10 ,  C07H15/12

    摘要： The invention provides carbohydrate based compounds, methods of preparation, and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a carbohydrate based compound of the invention having a core structure comprising of one or more sugar moieties. The carbohydrate based compounds are useful for inhibiting immune stimulation involving TLR ligands, especially TLR4 and TLR2. The compounds also are suitable for inhibition of inflammatory conditions resulting from infections. The compounds have use in the treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.

    摘要翻译： 本发明提供了基于碳水化合物的化合物，制备方法和用于通过Toll样受体调节信号传导的组合物。 所述方法包括使表达TLR的细胞与具有包含一个或多个糖部分的核心结构的本发明的基于碳水化合物的化合物接触。 基于碳水化合物的化合物可用于抑制涉及TLR配体，特别是TLR4和TLR2的免疫刺激。 所述化合物还适用于抑制由感染引起的炎性病症。 该化合物可用于治疗炎症，自身免疫，过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

    Compounds for treatment of lipase-mediated diseases
    3.
    发明申请
    Compounds for treatment of lipase-mediated diseases 失效
    用于治疗脂肪酶介导的疾病的化合物

    公开(公告)号：US20070054958A1

    公开(公告)日：2007-03-08

    申请号：US11222901

    申请日：2005-09-08

    申请人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

    发明人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

    IPC分类号： C07C50/04 ,  A61K31/275 ,  A61K31/215 ,  A61K31/13 ,  A61K31/26

    CPC分类号： C07C50/28 ,  C07C69/76 ,  C07C69/78 ,  C07C205/57

    摘要： Novel benzoquinone-derived compounds and polymorphs, prodrugs, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, and metabolic disorders are provided. Methods of use of the compounds for skin care, hair care and cosmetics are provided.

    摘要翻译： 提供了新的苯醌衍生化合物及其多晶型物，前体药物，几何或光学异构体，以及这些化合物的药学上可接受的酯，醚，氨基甲酸酯，肟，多晶型物，前体药物和异构体。 制备本发明化合物的方法和含有这些化合物的药物组合物及其用于降低或抑制脂肪酶基因家族用于治疗，改善或预防脂肪酶基因家族介导的疾病和病症（包括超重，肥胖，高脂血症，高胆固醇血症，高甘油三酯血症 ，胰腺炎，糖尿病，动脉粥样硬化，其他心血管疾病，代谢综合征和代谢紊乱。 提供了化合物用于护肤，护发和化妆品的方法。

    Compounds for treatment of lipase-mediated diseases
    4.
    发明授权
    Compounds for treatment of lipase-mediated diseases 失效
    用于治疗脂肪酶介导的疾病的化合物

    公开(公告)号：US07355055B2

    公开(公告)日：2008-04-08

    申请号：US11222901

    申请日：2005-09-08

    申请人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

    发明人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

    IPC分类号： C07C50/04 ,  C07C69/74 ,  A01N43/02

    CPC分类号： C07C50/28 ,  C07C69/76 ,  C07C69/78 ,  C07C205/57

    摘要： Novel benzoquinone-derived compounds and polymorphs, prodrugs, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, and metabolic disorders are provided. Methods of use of the compounds for skin care, hair care and cosmetics are provided.

    摘要翻译： 提供了新的苯醌衍生化合物及其多晶型物，前体药物，几何或光学异构体，以及这些化合物的药学上可接受的酯，醚，氨基甲酸酯，肟，多晶型物，前体药物和异构体。 制备本发明化合物的方法和含有这些化合物的药物组合物及其用于降低或抑制脂肪酶基因家族用于治疗，改善或预防脂肪酶基因家族介导的疾病和病症（包括超重，肥胖，高脂血症，高胆固醇血症，高甘油三酯血症 ，胰腺炎，糖尿病，动脉粥样硬化，其他心血管疾病，代谢综合征和代谢紊乱。 提供了化合物用于护肤，护发和化妆品的方法。

    A Composition Comprising Ex-Vivo Generated Dendritic Cells
    5.
    发明申请
    A Composition Comprising Ex-Vivo Generated Dendritic Cells 审中-公开
    包含体外生成树突状细胞的组合物

    公开(公告)号：US20170072049A1

    公开(公告)日：2017-03-16

    申请号：US15122718

    申请日：2015-03-05

    申请人： Shakti Upadhyay

    发明人： Shakti Upadhyay

    IPC分类号： A61K39/39 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K31/716 ,  A61K31/728 ,  A61K35/15 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/55583 ,  A61K2300/00

    摘要： The present invention relates to a composition comprising ex-vivo generated antigen-loaded dendritic cells in combination with β-glucan and hyaluronic acid or pharmaceutically acceptable derivatives thereof and methods of preparing and delivering the same. The present composition of the present invention enhances antigen-specific T cell response against cancer cells. The composition or formulation comprising the same is delivered through injection, biocampitable scaffold or implant by intradermal, subcutaneous, intramuscular, intratumoral, or intranodal administration for providing an effective immune response for treatment and/or prevention of cancer progression, recurrence, and/or metastasis in a cancer patient.

    摘要翻译： 本发明涉及包含与β-葡聚糖和透明质酸组合的离体产生的抗原负载的树突细胞或其药学上可接受的衍生物的组合物及其制备和递送方法。 本发明的本发明的组合物增强针对癌细胞的抗原特异性T细胞应答。 包含该组合物的组合物或制剂通过皮内，皮下，肌肉内，肿瘤内或淋巴管内注射，生物缓释支架或植入物递送，以提供用于治疗和/或预防癌症进展，复发和/或转移的有效免疫应答 在癌症患者。