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    Benzamide derivative and use thereof
    5.
    发明授权
    Benzamide derivative and use thereof 有权
    苯甲酰胺衍生物及其用途

    公开(公告)号：US09359346B2

    公开(公告)日：2016-06-07

    申请号：US14361638

    申请日：2012-11-29

    Applicant: VIVOZON, INC.

    Inventor： Doo Hyun Lee ,  Myung Soo Ham ,  Ji-Hyun Lee

    IPC: A61K31/47 ,  C07D295/12 ,  C07D217/22 ,  C07D211/26 ,  C07D413/04 ,  C07D211/58 ,  C07D207/09 ,  C07D455/02 ,  C07D285/12 ,  C07D405/04 ,  C07D211/44 ,  C07D207/14 ,  C07D453/02 ,  C07D309/14 ,  C07D215/38 ,  C07C235/50 ,  C07C235/54 ,  C07D211/34 ,  C07D295/15

    CPC classification number: C07D453/02 ,  A61K31/47 ,  C07C235/50 ,  C07C235/54 ,  C07D207/09 ,  C07D207/14 ,  C07D211/26 ,  C07D211/34 ,  C07D211/44 ,  C07D211/58 ,  C07D215/38 ,  C07D217/22 ,  C07D285/12 ,  C07D295/12 ,  C07D295/15 ,  C07D309/14 ,  C07D405/04 ,  C07D413/04 ,  C07D455/02

    Abstract: Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.

    Abstract translation: 公开了一种新型的苯甲酰胺衍生物及其药物用途，更具体地说，涉及具有式1结构的新型苯甲酰胺衍生物或其药学上可接受的盐，以及用于预防或治疗包括上述物质的疼痛或瘙痒的组合物。 根据本发明的新型苯甲酰胺衍生物及其药学上可接受的盐在神经病动物模型中表现出优异的疼痛抑制作用，特别是疼痛抑制作用，但也表现出其它模型如福尔马林模型，因此可能 用于抑制不良疼痛，例如伤害性疼痛，慢性疼痛等。此外，由于证明本发明即使在瘙痒模型中也显示抗瘙痒功效，其中针对疼痛建立了机制和治疗概念 本发明也可以有效地用于通过将本发明产品应用于抗瘙痒组合物进行自身治疗特应性皮炎，以抑制初始瘙痒期并治疗其症状，从而防止皮肤损伤或刮伤后的炎症 阶段。

    NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF
    7.
    发明申请
    NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF 有权
    新的苯甲酰衍生物及其用途

    公开(公告)号：US20140336378A1

    公开(公告)日：2014-11-13

    申请号：US14361638

    申请日：2012-11-29

    Applicant: VIVOZON, INC.

    Inventor： Doo Hyun Lee

    IPC: C07D453/02 ,  C07D215/38 ,  C07C235/54 ,  C07D309/14 ,  C07C235/50 ,  C07D295/15 ,  C07D211/34

    CPC classification number: C07D453/02 ,  A61K31/47 ,  C07C235/50 ,  C07C235/54 ,  C07D207/09 ,  C07D207/14 ,  C07D211/26 ,  C07D211/34 ,  C07D211/44 ,  C07D211/58 ,  C07D215/38 ,  C07D217/22 ,  C07D285/12 ,  C07D295/12 ,  C07D295/15 ,  C07D309/14 ,  C07D405/04 ,  C07D413/04 ,  C07D455/02

    Abstract: Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.

    Abstract translation: 公开了一种新型的苯甲酰胺衍生物及其药物用途，更具体地说，涉及具有式1结构的新型苯甲酰胺衍生物或其药学上可接受的盐，以及用于预防或治疗包括上述物质的疼痛或瘙痒的组合物。 根据本发明的新型苯甲酰胺衍生物及其药学上可接受的盐在神经病动物模型中表现出优异的疼痛抑制作用，特别是疼痛抑制作用，但也表现出其它模型如福尔马林模型，因此可能 用于抑制不良疼痛，例如伤害性疼痛，慢性疼痛等。此外，由于证明本发明即使在瘙痒模型中也显示抗瘙痒功效，其中针对疼痛建立了机制和治疗概念 本发明也可以有效地用于通过将本发明产品应用于抗瘙痒组合物进行自身治疗特应性皮炎，以抑制初始瘙痒期并治疗其症状，从而防止皮肤损伤或刮伤后的炎症 阶段。

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