公开(公告)号：US20060040364A1

公开(公告)日：2006-02-23

申请号：US11091899

申请日：2005-03-29

申请人： Vitaly Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokmakova

发明人： Vitaly Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokmakova

IPC分类号： C12P13/04 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08

摘要： A bacterium which has an ability to produce an amino acid and in which a novel rhtB gene encodes a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and cause accumulation of the amino acid in the medium, and the amino acid is recovered from the medium.

公开(公告)号：US20060014258A1

公开(公告)日：2006-01-19

申请号：US11091889

申请日：2005-03-29

申请人： Vitaly Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokmakova

发明人： Vitaly Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokmakova

IPC分类号： C12P13/04 ,  C12P13/08 ,  C12N1/21

CPC分类号： C12P13/06 ,  C07K14/245 ,  C12P13/04 ,  C12P13/08

摘要： A bacterium which has an ability to produce an amino acid and in which a novel rhtB gene encodes a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and cause accumulation of the amino acid in the medium, and the amino acid is recovered from the medium.

摘要翻译： 在培养基中培养具有生产氨基酸的能力的新型rhtB基因编码具有使具有L-高丝氨酸抗性蛋白的细菌的活性的蛋白质的细菌，从而产生并引起积累 的培养基中的氨基酸，并且从培养基中回收氨基酸。

公开(公告)号：US20050202543A1

公开(公告)日：2005-09-15

申请号：US11116286

申请日：2005-04-28

申请人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

发明人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

IPC分类号： C12P13/04 ,  C07K14/195 ,  C07K14/245 ,  C12N20060101 ,  C12N1/20 ,  C12N1/21 ,  C12N15/09 ,  C12N15/11 ,  C12N15/31 ,  C12P20060101 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12R1/185 ,  C12R1/19 ,  C12N15/74

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/24

摘要： A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.

摘要翻译： 描述了具有生产L-氨基酸能力的属于埃希氏菌属的细菌，其中通过增加L-氨基酸排泄蛋白的表达来增加产生L-氨基酸的能力。 还描述了使用该细菌生产L-氨基酸的方法。

公开(公告)号：US20080050784A1

公开(公告)日：2008-02-28

申请号：US11854850

申请日：2007-09-13

申请人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

发明人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

IPC分类号： C12P13/08 ,  C12P13/14 ,  C12P13/24

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/24

摘要： A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.

公开(公告)号：US20080050785A1

公开(公告)日：2008-02-28

申请号：US11854868

申请日：2007-09-13

申请人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

发明人： Vitaliy Livshits ,  Natalia Zakataeva ,  Kazuo Nakanishi ,  Vladimir Aleshin ,  Petr Troshin ,  Irina Tokhmakova

IPC分类号： C12P13/08 ,  C12P13/10 ,  C12P13/14

CPC分类号： C07K14/245 ,  C12P13/04 ,  C12P13/08 ,  C12P13/10 ,  C12P13/14 ,  C12P13/24

摘要： A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.

摘要翻译： 描述了具有生产L-氨基酸能力的属于埃希氏菌属的细菌，其中通过增加L-氨基酸排泄蛋白的表达来增加产生L-氨基酸的能力。 还描述了使用该细菌生产L-氨基酸的方法。

公开(公告)号：US20050239177A1

公开(公告)日：2005-10-27

申请号：US11106455

申请日：2005-04-15

申请人： Vitaliy Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokhmakova

发明人： Vitaliy Livshits ,  Natalia Zakataeva ,  Vladimir Aleshin ,  Alla Belareva ,  Irina Tokhmakova

IPC分类号： C12N15/09 ,  C07K14/245 ,  C12N1/20 ,  C12N1/21 ,  C12N15/31 ,  C12P13/06 ,  C12P13/08 ,  C12R1/19 ,  C12P13/04

CPC分类号： C12P13/08 ,  C07K14/245 ,  C12P13/06

摘要： The present invention describes a bacterium which has an ability to produce an amino acid and in which the rhtC gene encoding a protein having an enhanced activity of imparting L-threonine resistance to a bacterium expressing the protein. Preferably, the bacterium further includes an rhtB gene encoding for a protein having an enhanced activity of imparting to a bacterium L-homoserine resistance expressing the protein. The present invention also describes a method of cultivating the bacterium in a culture medium to produce and accumulate amino acids in the medium, and the amino acid is recovered from the medium.

摘要翻译： 本发明描述了具有产生氨基酸的能力的细菌，其中编码具有增强的表达蛋白质的细菌的L-苏氨酸抗性活性的蛋白质的rhtC基因。 优选地，细菌还包括编码具有增强的表达蛋白质的L-高丝氨酸抗性细菌活性的蛋白质的rhtB基因。 本发明还描述了在培养基中培养细菌以在培养基中产生和积累氨基酸的方法，并且从培养基中回收氨基酸。