公开(公告)号：US06927229B2

公开(公告)日：2005-08-09

申请号：US10462412

申请日：2003-06-16

申请人： Jackson Boling Hester, Jr. ,  Wade J. Adams ,  Jeffrey Charles Stevens ,  Mikhail Fedor Gordeev ,  Upinder Singh ,  Carole Scott

发明人： Jackson Boling Hester, Jr. ,  Wade J. Adams ,  Jeffrey Charles Stevens ,  Mikhail Fedor Gordeev ,  Upinder Singh ,  Carole Scott

IPC分类号： C07D263/26 ,  A61K31/422 ,  A61K31/541 ,  A61K31/554 ,  A61P31/04 ,  C07D263/20 ,  C07D413/10 ,  C07D417/10

CPC分类号： C07D263/20 ,  C07D413/10 ,  C07D417/10

摘要： The present invention describes difluororthioacetamide oxazolidinones of formula I: R is —CH2— or —CH2CH2—; R2 and R3 are independently —H or —F; X is —CH—; Y is —SO—, —SO2—, or —SONR4—; and R4 is —H or —C1-4alkyl. These compounds are useful to treat infectives diseases caused by gram-positive and gram-negative bacteria.

摘要翻译： 本发明描述了式I的二氟代乙酰胺恶唑烷酮：R是-CH 2 - 或-CH 2 CH 2 - 。 R 2和R 3独立地是-H或-F; X是-CH-; Y是-SO - ， - SO 2 - 或-SONR 4 - 。 R 4是-H或-C 1-4烷基。 这些化合物可用于治疗由革兰氏阳性和革兰氏阴性菌引起的感染性疾病。

公开(公告)号：US4335620A

公开(公告)日：1982-06-22

申请号：US169327

申请日：1980-07-16

申请人： Wade J. Adams

发明人： Wade J. Adams

IPC分类号： G01N1/18 ,  G01N30/24 ,  G01N30/30 ,  G01N35/04

CPC分类号： G01N1/18 ,  G01N30/30 ,  G01N30/24

摘要： A temperature controlled sample carrier, usable in liquid chromatography apparatus, includes a rotating sample rack having a circumferential array of upward facing sample holes adjacent its periphery for receiving sample vials and orbiting same sequentially past a sampling station. The rack is a solid cylindrical block of heat conducting material which forms a massive heat sink. An insulative cup receives the sample block and rotates therewith. A temperature control device carries a controlled temperature fluid in heat conductive contact with the central portion of the sample block and is overlaid by an insulative cover device which rotates with the block. An insulative cover ring is fixed with respect to the sampling station, overlies the array of sample holes in the block, and extends between the peripheral wall of the cup and the cover device. A circumferentially narrow opening in the cover ring permits access by a sampling device at the sampling station to the upper ends of sequentially presented sample vials rotating therepast with the sample block.

摘要翻译： 可用于液相色谱装置的温度控制的样品载体包括旋转的样品架，其具有与其周边相邻的向上面向的样品孔的周向阵列，用于接收样品瓶并且顺序地通过取样台。 机架是形成大块散热片的实心圆柱形导热材料块。 绝缘杯接收样品块并随之旋转。 温度控制装置承载与样品块的中心部分导热接触的受控温度流体，并且由与块一起旋转的绝缘覆盖装置覆盖。 绝缘盖环相对于采样台固定，覆盖在块体中的样品孔阵列上，并且在杯的周壁和覆盖装置之间延伸。 盖环中的周向狭窄的开口允许通过采样站的采样装置进入与样品块一起旋转的顺序呈现的样品瓶的上端。

公开(公告)号：US06124306A

公开(公告)日：2000-09-26

申请号：US157975

申请日：1998-09-21

申请人： Joel Morris ,  Wade J. Adams ,  Janice M. Friis ,  Donn G. Wishka

发明人： Joel Morris ,  Wade J. Adams ,  Janice M. Friis ,  Donn G. Wishka

IPC分类号： C07D239/58 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61P31/18 ,  C07D239/26 ,  C07D239/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D491/04 ,  C07D491/048 ,  C07D239/34

CPC分类号： C07D401/12 ,  C07D491/04

摘要： The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R.sub.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; andR.sub.6 is --S--C.sub.1-6 alkyl (preferably --SCH.sub.3);The compounds of Formula I are useful in the treatment of individuals who are HIV positive.

摘要翻译： 本发明涉及式I的嘧啶 - 硫代烷基和烷基醚化合物和式I的嘧啶 - 硫代烷基和烷基醚，其中R 4选自-H或-NR 15 R 16，其中R 15是-H且R 16是-H，C 1 -C 1-6烷基，-NH 2或R 15和R 16与-N形式的1-吡咯烷子基，1-吗啉代或1-哌啶子基一起使用; 并且R 6是-S-C 1-6烷基（优选-SCH 3）; 式I的化合物可用于治疗HIV阳性的个体。