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    Imidazole derivatives for the treatment of gastrointestinal disorders
    6.
    发明授权
    Imidazole derivatives for the treatment of gastrointestinal disorders 失效
    咪唑衍生物用于治疗胃肠道疾病

    公开(公告)号：US07745474B2

    公开(公告)日：2010-06-29

    申请号：US12158167

    申请日：2006-12-21

    申请人： Udo Bauer ,  Wayne Brailsford ,  Linda Gustafsson ,  Tor Svensson ,  Maria Saxin

    发明人： Udo Bauer ,  Wayne Brailsford ,  Linda Gustafsson ,  Tor Svensson ,  Maria Saxin

    IPC分类号： A61K31/417 ,  A61K31/4174 ,  C07D233/64 ,  C07D233/88

    CPC分类号： C07D233/90 ,  C07D405/12

    摘要： The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R1, R2, R3 and Y are as defined in the description. For example, R1 may be phenyl, R2 may be dimethylamino, R3 may be alkoxy and Y may be a thioylamino- or methyl eneamino- linked substitutuent containing an aryl group.

    摘要翻译： 本发明涉及具有正变构GABA B受体（GBR）调节剂作用的新型咪唑衍生物，用于制备所述化合物的方法及其用途，任选与GABAB激动剂组合用于抑制短暂食管括约肌松弛， 用于治疗胃食管反流疾病，以及治疗功能性胃肠道疾病和肠易激综合征（IBS）。 化合物由通式（I）表示，其中R 1，R 2，R 3和Y如说明书中所定义。 例如，R 1可以是苯基，R 2可以是二甲基氨基，R 3可以是烷氧基，Y可以是含有芳基的硫代氨基 - 或甲基烯氨基连接的取代基。

    Mixer apparatus
    8.
    发明授权
    Mixer apparatus 失效
    搅拌机

    公开(公告)号：US4104737A

    公开(公告)日：1978-08-01

    申请号：US685737

    申请日：1976-05-13

    申请人： Gerold Wayne Brailsford

    发明人： Gerold Wayne Brailsford

    IPC分类号： B07B1/52 ,  B28C5/12 ,  B28C5/00 ,  B01F7/18

    CPC分类号： B07B1/528 ,  B28C5/1215

    摘要： A portable mixer includes a generally cylindrical housing open at one end thereof, and a mixer blade disposed to rotate within the housing. Located at the other end of the housing is a driven pulley coupled by a belt to a drive pulley mounted on a motor. The driven pulley is coupled through the end of the housing to the mixer blade so that when the driven pulley is rotated, the mixer blade is caused to rotate. The mixer blade includes an elongate, generally flat member which is disposed to rotate in a plane defined by the opening in the housing so that when the housing is placed upon a flat surface, the elongate member rotates just above the surface. The mixer blade also includes a second elongate, generaly flat member spaced from the first mentioned member and disposed to rotate adjacent the inside surface of the wall at the other end of the housing, and a third elongate, generally flat member which extends between the first and second members at one end thereof and is disposed to move adjacent the inside surface of the cylindrical walls of the housing. A switch is mounted in the housing to enable the operation of the motor when the housing is placed with the opening face down on a surface, and to disable the motor when the housing is lifted from the surface.

    摘要翻译： 便携式混合器包括在其一端开口的大致圆柱形的壳体和设置成在壳体内旋转的混合器叶片。 位于壳体另一端的是由皮带轮连接到安装在马达上的驱动皮带轮的从动皮带轮。 从动带轮通过壳体的端部联接到混合器叶片，使得当从动带轮旋转时，使混合器叶片旋转。 混合器叶片包括细长的大致平坦的构件，其被设置为在由壳体中的开口限定的平面中旋转，使得当壳体被放置在平坦表面上时，细长构件刚好在表面上方旋转。 混合器叶片还包括与第一所述构件间隔开并设置成在壳体的另一端处邻近壁的内表面旋转的第二细长的通用平面构件，以及第三细长的大体上平坦的构件，其在第一 并且其一端具有第二构件，并且设置成邻近壳体的圆柱形壁的内表面移动。 开关安装在壳体中，以便当壳体以开口面向下放置在表面上时使马达能够操作，并且当壳体从表面抬起时禁止马达。

    Carbazole derivatives and their use as NPY5 receptor antagonists
    9.
    发明授权
    Carbazole derivatives and their use as NPY5 receptor antagonists 有权
    咔唑衍生物及其用作NPY5受体拮抗剂

    公开(公告)号：US07408064B2

    公开(公告)日：2008-08-05

    申请号：US10488982

    申请日：2002-09-09

    申请人： Kevin Michael Foote ,  Michael Howard Block ,  Wayne Brailsford

    发明人： Kevin Michael Foote ,  Michael Howard Block ,  Wayne Brailsford

    IPC分类号： C07D471/04 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor: wherein: R1, R2, R3 and X1-X6 are as defined within or a pharmaceutically acceptable salt, prodrug or solvate thereof, is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.

    摘要翻译： 式（I）化合物在制备用于在温血动物中治疗由神经肽Y5受体介导的病症的药物中的用途：其中：R 1，R 2， R 2，R 3和X 1 -X 6如本文所定义或其药学上可接受的盐，前药或溶剂化物 描述。 还描述了制备式（I）化合物的药物组合物，方法和方法。