公开(公告)号：US11919899B2

公开(公告)日：2024-03-05

申请号：US18002717

申请日：2020-09-21

申请人： Wei Zhong

发明人： Wei Zhong

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00 ,  C07B2200/05

摘要： The present invention discloses substituted 1-(3,3-difluoropiperidin-4-yl)-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one compounds having a capacity to cross the blood-brain barrier; the compound has the structural formula represented by formula (I):




The substituted 1-(3,3-difluoropiperidin-4-yl)-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one compounds, derivatives and pharmaceutically acceptable salts thereof of the present invention have the ability to cross the blood-brain barrier and are capable of acting as a drug characteristic of a protein kinase inhibitor, in particular for the expression of a protein through an Ataxia-telangiectasia mutated kinase (ATM) and can be used to treat or prevent disorders associated with abnormal protein kinase activity, such as cancer, cancer with brain metastases, cancer with meningeal metastases, glioma, glioblastoma, DIPG, and the like either as monotherapy or combination with other treatment.

公开(公告)号：US20150296202A1

公开(公告)日：2015-10-15

申请号：US14680245

申请日：2015-04-07

申请人： Wei ZHONG ,  Kiichiro Saito

发明人： Wei ZHONG ,  Kiichiro Saito

IPC分类号： H04N13/02 ,  G06K9/46 ,  B60R1/00 ,  H04N5/265 ,  G06K9/62 ,  G06T7/00

CPC分类号： H04N13/296 ,  B60R1/00 ,  B60R2300/107 ,  G06K9/00805 ,  G06K9/6202 ,  G06K2209/40 ,  G06T7/593 ,  G06T2207/20016 ,  G06T2207/30252 ,  H04N13/239 ,  H04N2013/0081

摘要： An image reducer executes a reduction process on a comparison image to generate a reduced comparison image, and executes a reduction process on a reference image to generate a reduced reference image. A disparity value deriver (a deriving unit) derives a disparity value by setting the minimum value of synthesized costs of pixels in the reduced comparison image in connection with a reference pixel in the reduced reference image, which have been calculated by a cost synthesizer. A disparity image generator generates a reduced disparity image, which is an image obtained by replacing the luminance values of the respective pixels in the reduced reference image with the disparity values corresponding to the pixels. The disparity image enlarger executes an enlargement process for enlarging the image size of the reduced disparity image generated by the disparity image generator to generate a disparity image.

摘要翻译： 图像缩小器对比较图像执行缩小处理以生成缩小的比较图像，并对参考图像执行缩小处理以生成缩小的参考图像。 视差值提升（派生单元）通过将缩减比较图像中的像素的合成成本的最小值与已经由成本合成器计算的缩小参考图像中的参考像素相关联地导出视差值。 视差图像生成器生成缩小的视差图像，其是通过用与像素对应的视差值替换缩小参考图像中的各个像素的亮度值而获得的图像。 视差图像放大器执行放大处理，用于放大由视差图像发生器产生的缩小的视差图像的图像尺寸，以产生视差图像。

公开(公告)号：US07475112B2

公开(公告)日：2009-01-06

申请号：US11073417

申请日：2005-03-04

申请人： Andrew Sinclair ,  Timothy M. Moore ,  Warren Vincent Barkley ,  Wei Zhong

发明人： Andrew Sinclair ,  Timothy M. Moore ,  Warren Vincent Barkley ,  Wei Zhong

IPC分类号： G06F15/16 ,  G06T1/00 ,  G06T15/00

CPC分类号： H04N7/15 ,  G06F2203/04802 ,  H04N7/142 ,  H04N7/147

摘要： A presentation system receives streams of videos of a video conference and presents the videos on the faces of a three-dimensional object. The presentation system selects which video should be presented more prominently than the other videos. The presentation system generates an image of the three-dimensional object that represents a view location from which the selected video is prominently visible and videos of other conference participants are less prominently visible. The presentation system then displays the image to the conference participant.

摘要翻译： 呈现系统接收视频会议的视频流，并将视频呈现在三维对象的面上。 演示系统选择哪个视频应该比其他视频更显眼。 演示系统生成三维物体的图像，该三维物体表示所选择的视频显着地可见的观看位置，而其他会议参与者的视频不那么突出地可见。 演示系统然后将该图像显示给会议参与者。

公开(公告)号：US20090001127A1

公开(公告)日：2009-01-01

申请号：US11814664

申请日：2005-06-29

申请人： Wang-dong Chen ,  Quan Chen ,  Jiang Lin ,  Ming-yao Lu ,  Wei-zhong Yin

发明人： Wang-dong Chen ,  Quan Chen ,  Jiang Lin ,  Ming-yao Lu ,  Wei-zhong Yin

IPC分类号： A61B17/03

CPC分类号： A61B17/115 ,  A61B17/1114 ,  A61B17/1155 ,  A61B17/32053

摘要： The present invention provides a rotatable stapling head of a surgical stapler, which comprises a staple cartridge (1), a staple driver (2), a scalpel (3), a compression rod (4), a staple casing (5) and a rotating assembly. The above parts constitute a rotating forward mechanism which can rotatablely forward the scalpel therein.

摘要翻译： 本发明提供了一种外科缝合器的可旋转缝合头，其包括钉仓（1），钉驱动器（2），解剖刀（3），压缩杆（4），钉壳（5）和 旋转组件。 上述部件构成能够使解剖刀旋转的旋转向前机构。

公开(公告)号：US20070294346A1

公开(公告)日：2007-12-20

申请号：US11454593

申请日：2006-06-16

申请人： Tim M. Moore ,  Dalibor Kukoleca ,  Wei Zhong ,  Warren V. Barkley ,  Danny Levin

发明人： Tim M. Moore ,  Dalibor Kukoleca ,  Wei Zhong ,  Warren V. Barkley ,  Danny Levin

IPC分类号： G06F15/16

CPC分类号： H04L63/065 ,  H04N7/15 ,  H04N21/2662 ,  H04N21/64769 ,  H04N21/64792

摘要： A conference server may request a key frame from a conference participant in response to determining that the conference participant should become a most active participant, and the conference server may make the conference participant the most active participant in response to receiving the key frame from the conference participant.

摘要翻译： 响应于确定会议参与者应该成为最活跃的参与者，会议服务器可以从会议参与者请求关键帧，并且会议服务器可以使会议参与者响应于从会议接收到关键帧而使会议参与者成为最活跃的参与者 参与者

公开(公告)号：US20070220162A1

公开(公告)日：2007-09-20

申请号：US11378163

申请日：2006-03-17

申请人： Danny Levin ,  Warren Berkley ,  Wei Zhong ,  Tim Moore ,  Michael VanBuskirk ,  Yiu-Ming Leung

发明人： Danny Levin ,  Warren Berkley ,  Wei Zhong ,  Tim Moore ,  Michael VanBuskirk ,  Yiu-Ming Leung

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： H04L65/1043 ,  H04L65/605 ,  H04N7/17336 ,  H04N21/2368 ,  H04N21/4341 ,  H04N21/4788 ,  H04N21/8106

摘要： Techniques are described for providing media services. A media processor receives one or more input media streams and provides an output media stream to one or more endpoints. A media controller issues commands to the media processor for controlling the media streams. The media controller and the media processor communicate in accordance with a defined protocol allowing for independent control of each of the media streams.

摘要翻译： 描述了提供媒体服务的技术。 媒体处理器接收一个或多个输入媒体流并向一个或多个端点提供输出媒体流。 媒体控制器向媒体处理器发出命令以控制媒体流。 媒体控制器和媒体处理器根据定义的协议进行通信，允许独立控制每个媒体流。

公开(公告)号：US20070165820A1

公开(公告)日：2007-07-19

申请号：US11275559

申请日：2006-01-13

申请人： Anton Krantz ,  Dalibor Kukoleca ,  Wei Zhong ,  Guo-Wei Shieh ,  Zong Zong Yuan ,  Tim Moore ,  Danny Levin ,  Michael VanBuskirk

发明人： Anton Krantz ,  Dalibor Kukoleca ,  Wei Zhong ,  Guo-Wei Shieh ,  Zong Zong Yuan ,  Tim Moore ,  Danny Levin ,  Michael VanBuskirk

IPC分类号： H04M3/42

CPC分类号： H04M7/006 ,  H04M3/568 ,  H04M3/569

摘要： Systems, methods, and/or techniques (“tools”) are described that sort speakers in a network-enabled conference. In some cases, this sorted list of speakers indicates which speaker is dominant. With this sorted list, a participant's communication device may provide context about the speakers. In some cases a participant's communication device has a display that presents real-time video of the speakers or other visual indicia, such as each or the most dominant speaker's name, picture, title, or location. These and other context about speakers may help participants better understand discussions in network-enabled conferences.

摘要翻译： 描述了在启用网络的会议中对扬声器进行排序的系统，方法和/或技术（“工具”）。 在某些情况下，这个排序的扬声器列表指示哪个扬声器占主导地位。 通过该排序列表，参与者的通信设备可以提供关于扬声器的上下文。 在某些情况下，参与者的通信设备具有呈现扬声器的实时视频或其他视觉标记的显示器，例如每个或最主要的扬声器的名称，图片，标题或位置。 关于演讲者的这些和其他背景可能有助于参与者更好地了解网络会议中的讨论。

公开(公告)号：US20070115949A1

公开(公告)日：2007-05-24

申请号：US11281113

申请日：2005-11-17

申请人： Mu Han ,  Warren Barkley ,  Wei Zhong ,  Gurdeep Pall

发明人： Mu Han ,  Warren Barkley ,  Wei Zhong ,  Gurdeep Pall

IPC分类号： H04L12/66

CPC分类号： H04L29/06027 ,  H04L65/103 ,  H04L65/104 ,  H04L65/605 ,  H04L65/80

摘要： Various technologies and techniques are disclosed that improve media communications. In one embodiment, a media server receives a media communication with a first quality from a personal computer with VoIP telephone capabilities. The media server translates the media (e.g., audio, visual, etc.) communication into a second quality, and forwards the media communication to a communication gateway. The translation to improve communications can also be done when receiving the media communication from the communication gateway for forwarding to the persona computer having VoIP telephone capability. In some embodiments, a media server sits in the communication channel between a personal computer with VoIP telephone capabilities and a communication gateway and is able to translate communications into codec protocols they each understand.

摘要翻译： 公开了改进媒体通信的各种技术和技术。 在一个实施例中，媒体服务器从具有VoIP电话能力的个人计算机接收具有第一质量的媒体通信。 媒体服务器将媒体（例如，音频，视频等）通信转换成第二质量，并将媒体通信转发到通信网关。 当从通信网关接收媒体通信以转发到具有VoIP电话能力的个人计算机时，也可以进行改善通信的转换。 在一些实施例中，媒体服务器位于具有VoIP电话能力的个人计算机和通信网关之间的通信信道中，并且能够将通信转换为他们都理解的编解码器协议。

公开(公告)号：US20060029979A1

公开(公告)日：2006-02-09

申请号：US11196305

申请日：2005-08-04

申请人： Chunxue Bai ,  Wei Zhong ,  Yuanlin Song

发明人： Chunxue Bai ,  Wei Zhong ,  Yuanlin Song

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/582 ,  G01N33/84

摘要： The present invention relates to the preparation ad application of a high-sensitive electrochemical luminescent composite material which has anti-biofouling properties useful as a sensor material. This material is prepared by immobilization of electrochemical luminescent material into polymer containing phospholipid groups, wherein, the electrochemical luminescent material including ruthenium complex, osmium complex, etc.; the phospholipid containing polymer is the copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and other polymerisable monomers. Animal experiment results revealed that this composite material has good anti-biofouling properties; it can be used in producing various sensors for bio-related detections.

摘要翻译： 本发明涉及具有抗生物污损性的高灵敏度电化学发光复合材料作为传感器材料的制备方法。 该材料通过将电化学发光材料固定在含有磷脂基团的聚合物中而制备，其中，电化学发光材料包括钌络合物，锇络合物等; 含磷脂的聚合物是2-甲基丙烯酰氧基乙基磷酸胆碱（MPC）和其它可聚合单体的共聚物。 动物实验结果表明，该复合材料具有良好的抗生物污损性能; 它可用于生产用于生物相关检测的各种传感器。

公开(公告)号：US06441960B1

公开(公告)日：2002-08-27

申请号：US09653759

申请日：2000-09-01

申请人： Mark S. Wang ,  Wei-Zhong Li

发明人： Mark S. Wang ,  Wei-Zhong Li

IPC分类号： G02B530

CPC分类号： G02B6/272 ,  G02B6/2766 ,  G02B6/29302 ,  G02B6/29361 ,  G02B6/29386 ,  G02B6/29394 ,  G02B27/283 ,  H04J14/02 ,  H04J14/06

摘要： The present invention provides a line of optical interleavers in which a novel beam-swapping element is utilized. The beam-swapping element of the present invention provides an effective and inexpensive alternative to polarization rotators and birefrigent elements employed in the prior art optical interleavers, hence rendering a simple and low-cost assembly to the optical interleavers of the present invention. The optical interleavers of the present invention further advantageously exploit a combination of two wavelength filters to cancel out wavelength-filter-induced-dispersion. Efforts are also painstakingly made in the optical interleavers of the present invention to substantially minimize other dispersion effects. As such, the optical interleavers of the present invention constitute the first kind in the art in which various dispersion effects are substantially minimized. Such characteristics would be highly desirable in fiber-optic networks. The optical interleavers of the present invention can be advantageously configured as multiplexers, de-multiplexers, or routers.

摘要翻译： 本发明提供了一种光交错器，其中使用了一种新的光束交换元件。 本发明的光束交换元件为现有技术的光学交织器中使用的偏振旋转器和双折射元件提供了有效且便宜的替代方案，因此为本发明的光交错器提供简单且低成本的组件。 本发明的光交织器进一步有利地利用两个波长滤波器的组合来抵消波长滤波器诱导的色散。 在本发明的光学交织器中也努力地进行了努力，以使其它分散效果基本上最小化。 因此，本发明的光学交织器构成了本领域的第一种，其中各种色散效应基本上最小化。 这种特性在光纤网络中将是非常需要的。 本发明的光交织器可以有利地配置为多路复用器，解复用器或路由器。