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8 条记录 (耗时 0.018 秒)

    Modulators of angiogenesis
    1.
    发明授权
    Modulators of angiogenesis 有权
    血管生成调节剂

    公开(公告)号：US07244576B2

    公开(公告)日：2007-07-17

    申请号：US09935124

    申请日：2001-08-21

    申请人： James B. Lorens ,  Weiduan Xu ,  Robert E. Atchison ,  Jakob Bogenberger

    发明人： James B. Lorens ,  Weiduan Xu ,  Robert E. Atchison ,  Jakob Bogenberger

    IPC分类号： G01N33/567

    CPC分类号： C12Q1/42 ,  A61K38/00 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

    摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding C1-angiogenesis protein, also called integrin-linked kinase associated protein (“ILKAP”) and ILKAP protein, which is involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate angiogenesis via modulation of ILKAP and ILKAP-related cascades; as well as to the use of expression profiles and compositions in diagnosis and therapy of angiogenesis.

    摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码C1-血管发生蛋白的核酸，也称为整合素连接的激酶相关蛋白（“ILKAP”）和ILKAP蛋白，其涉及血管发生的调节。 本发明进一步涉及用于鉴定和使用通过调节ILKAP和ILKAP相关级联来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸和核酶的方法; 以及在血管生成诊断和治疗中使用表达谱和组合物。

    Modulators of angiogenesis
    3.
    发明申请
    Modulators of angiogenesis 有权
    血管生成调节剂

    公开(公告)号：US20060264392A1

    公开(公告)日：2006-11-23

    申请号：US10525573

    申请日：2003-09-02

    申请人： James Lorens ,  Jakob Bogenberger ,  Sacha Holland ,  Weiduan Xu

    发明人： James Lorens ,  Jakob Bogenberger ,  Sacha Holland ,  Weiduan Xu

    IPC分类号： A61K48/00 ,  A61K38/54 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6883 ,  C07K14/4702 ,  C12Q2600/158

    摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic adds, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.

    摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管生成调节蛋白和核酸调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸添加物，RNAi和核酶的试剂; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。

    Modulators of angiogenesis
    4.
    发明授权
    Modulators of angiogenesis 有权
    血管生成调节剂

    公开(公告)号：US07527936B2

    公开(公告)日：2009-05-05

    申请号：US11036643

    申请日：2005-01-13

    申请人： Weiduan Xu ,  Sacha J. Holland ,  James Lorens

    发明人： Weiduan Xu ,  Sacha J. Holland ,  James Lorens

    IPC分类号： G01N33/573 ,  C12N15/06 ,  C12N15/52 ,  C12N9/14 ,  C12N5/10

    CPC分类号： G01N33/566 ,  C12Q1/32 ,  C12Q1/37 ,  C12Q1/485 ,  G01N2333/515

    摘要： The present invention relates to regulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis; as well as to the use of expression profiles and compositions in diagnosis and therapy of angiogenesis and cancer.

    摘要翻译： 本发明涉及血管发生的调节。 本发明还涉及用于鉴定和使用调节血管发生的试剂的方法，所述试剂包括调节血管生成的小有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶; 以及在血管发生和癌症的诊断和治疗中使用表达谱和组合物。

    Modulators of angiogenesis
    5.
    发明授权
    Modulators of angiogenesis 有权
    血管生成调节剂

    公开(公告)号：US07419779B2

    公开(公告)日：2008-09-02

    申请号：US10525573

    申请日：2003-09-02

    申请人： James B. Lorens ,  Jakob Bogenberger ,  Sacha Holland ,  Weiduan Xu

    发明人： James B. Lorens ,  Jakob Bogenberger ,  Sacha Holland ,  Weiduan Xu

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C12N5/00

    CPC分类号： C12Q1/6883 ,  C07K14/4702 ,  C12Q2600/158

    摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.

    摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管发生调节蛋白和核酸来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶的试剂; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。

    Modulators of angiogenesis and tumorigenesis
    6.
    发明授权
    Modulators of angiogenesis and tumorigenesis 有权
    血管发生和肿瘤发生的调节剂

    公开(公告)号：US07566546B2

    公开(公告)日：2009-07-28

    申请号：US11060659

    申请日：2005-02-16

    申请人： James Lorens ,  Sacha J. Holland ,  Weiduan Xu

    发明人： James Lorens ,  Sacha J. Holland ,  Weiduan Xu

    IPC分类号： G01N33/567 ,  G01N33/53 ,  G01N33/573

    CPC分类号： G01N33/5029 ,  G01N33/5011 ,  G01N33/5064

    摘要： The present invention relates to regulation of angiogenesis and tumorigenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis via modulation of endothelial cell haptotaxis; as well as to the use of expression profiles and compositions in diagnosis and therapy of angiogenesis and cancer.

    摘要翻译： 本发明涉及血管生成和肿瘤发生的调节。 本发明还涉及用于鉴定和使用通过调节内皮细胞触觉性调节血管生成的试剂，包括小的有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶等的方法。 以及在血管发生和癌症的诊断和治疗中使用表达谱和组合物。

    Modulators of angiogenesis
    7.
    发明授权
    Modulators of angiogenesis 有权
    血管生成调节剂

    公开(公告)号：US07485414B2

    公开(公告)日：2009-02-03

    申请号：US10231956

    申请日：2002-08-30

    申请人： James B. Lorens ,  Weiduan Xu ,  Jakob Bogenberger ,  Sacha Holland

    发明人： James B. Lorens ,  Weiduan Xu ,  Jakob Bogenberger ,  Sacha Holland

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C12N5/00

    CPC分类号： C12Q1/6883 ,  C07K14/4702 ,  C12Q2600/158

    摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.

    摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管发生调节蛋白和核酸来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶的方法; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。