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公开(公告)号：US07419779B2
公开(公告)日：2008-09-02
申请号：US10525573
申请日：2003-09-02
申请人： James B. Lorens , Jakob Bogenberger , Sacha Holland , Weiduan Xu
发明人： James B. Lorens , Jakob Bogenberger , Sacha Holland , Weiduan Xu
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/567 , C12N5/00
CPC分类号： C12Q1/6883 , C07K14/4702 , C12Q2600/158
摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.
摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管发生调节蛋白和核酸来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶的试剂; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。
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公开(公告)号：US07485414B2
公开(公告)日：2009-02-03
申请号：US10231956
申请日：2002-08-30
申请人： James B. Lorens , Weiduan Xu , Jakob Bogenberger , Sacha Holland
发明人： James B. Lorens , Weiduan Xu , Jakob Bogenberger , Sacha Holland
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/567 , C12N5/00
CPC分类号： C12Q1/6883 , C07K14/4702 , C12Q2600/158
摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.
摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管发生调节蛋白和核酸来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸，RNAi和核酶的方法; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。
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公开(公告)号：US07244576B2
公开(公告)日：2007-07-17
申请号：US09935124
申请日：2001-08-21
IPC分类号： G01N33/567
CPC分类号： C12Q1/42 , A61K38/00 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding C1-angiogenesis protein, also called integrin-linked kinase associated protein (“ILKAP”) and ILKAP protein, which is involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate angiogenesis via modulation of ILKAP and ILKAP-related cascades; as well as to the use of expression profiles and compositions in diagnosis and therapy of angiogenesis.
摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码C1-血管发生蛋白的核酸，也称为整合素连接的激酶相关蛋白（“ILKAP”）和ILKAP蛋白，其涉及血管发生的调节。 本发明进一步涉及用于鉴定和使用通过调节ILKAP和ILKAP相关级联来调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸和核酶的方法; 以及在血管生成诊断和治疗中使用表达谱和组合物。
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公开(公告)号：US20060264392A1
公开(公告)日：2006-11-23
申请号：US10525573
申请日：2003-09-02
申请人： James Lorens , Jakob Bogenberger , Sacha Holland , Weiduan Xu
发明人： James Lorens , Jakob Bogenberger , Sacha Holland , Weiduan Xu
IPC分类号： A61K48/00 , A61K38/54 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6883 , C07K14/4702 , C12Q2600/158
摘要： The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic adds, RNAi, and ribozymes, that modulate angiogenesis via modulation of angiogenesis regulatory proteins and nucleic acids; as well as to the use of expression profiles and compositions in diagnosis and therapy of diseases related to angiogenesis.
摘要翻译： 本发明涉及血管发生的调节。 更具体地，本发明涉及编码血管发生调节的“血管发生调节蛋白和核酸”的核酸。 本发明还涉及用于鉴定和使用通过调节血管生成调节蛋白和核酸调节血管生成的试剂，包括小有机分子，抗体，肽，环肽，核酸，反义核酸添加物，RNAi和核酶的试剂; 以及在血管生成相关疾病的诊断和治疗中使用表达谱和组合物。
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5.发明申请Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use 审中-公开双向克隆随机cDNA表达载体文库，组合物和使用方法公开(公告)号：US20070166769A1
公开(公告)日：2007-07-19
申请号：US11715649
申请日：2007-03-07
申请人： James Lorens , Jakob Bogenberger
发明人： James Lorens , Jakob Bogenberger
CPC分类号： C12N15/1082 , C07K2319/03 , C07K2319/60 , C12N15/62 , G01N2500/10
摘要： The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector types to host cells. Methods for producing these libraries through bi-directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.
摘要翻译： 本发明提供了随机cDNA表达载体文库，其包含表达载体，其包含位于正义和反义方向的随机cDNA，其可用于将宿主细胞的遗传效应子类型的组合递送和表达。 还提供了通过双向克隆随机cDNA产生这些文库的方法。 本文还提供了使用这些文库筛选能够以期望的方式调节细胞表型的试剂的方法。
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