公开(公告)号：US20090185160A1

公开(公告)日：2009-07-23

申请号：US12278573

申请日：2007-02-02

Applicant: Werner Mäntele ,  Vitali Vogel ,  Oliver Klein ,  Lea Schröder

Inventor： Werner Mäntele ,  Vitali Vogel ,  Oliver Klein ,  Lea Schröder

IPC: G01N33/48 ,  G01N21/47 ,  G01N15/02

CPC classification number: G01N15/0205 ,  G01N21/51 ,  G01N21/532 ,  G01N2015/0038 ,  G01N2015/0065 ,  G01N2021/4711 ,  G01N2021/4742 ,  G01N2021/4769

Abstract: The present invention relates to a measuring device to determine the size, size distribution and/or concentration of nanoscopic particles or hollow spaces in a measuring sample, the degree of opacity of such measuring samples, or the degree of roughness of surfaces by determining the wavelength and scattering angle dependent intensities of a measuring radiation scattered on a measuring sample, comprising a retaining device for a measuring sample to be measured, a detector, comprising at least one detector inlet, an evaluation unit and at least two radiation sources, which are respectively at a distance from each other and at a distance from the measuring sample, which comprise a multiple wavelength spectrum or a continuous spectrum, and the radiation intensities of which are adjustable and/or determinable, wherein via the radiation sources one ray bundle can in each case be emitted in an essentially parallel beam in the direction of a measuring sample, and wherein the ray bundles which can be directed onto the measuring sample, which have different radiation sources in relation to the axis between the detector inlet and the measuring sample, are aligned or can be aligned in different angles onto the measuring sample.Furthermore, the invention relates to a method for determining the size and/or concentration of particles or hollow spaces in the nanoscopic range in a viscous, fluid or gaseous measuring sample, comprising the following stages: a) the provision of a measuring device according to the invention, b) the provision of a measuring sample to be measured in the retaining device for the measuring sample, c) the radiation of the measuring sample with at least two radiation sources, comprising the radiation of a multiple wavelength or of a continuous spectrum, with ray bundles of essentially parallel rays, d) the detection of the radiation scattered at a particular angle on the measuring sample using a detector comprising a detector inlet, and e) the wavelength and angle-dependent evaluation of the detected signal intensities of the scattered radiation in an evaluation unit in order to determine the size, size distribution and/or concentration of the nanoscopic particles present in the measuring sample. The invention also relates to a method for determining the heparin share in blood samples or in blood serum samples, comprising: a) the provision of a measuring device according to the invention, b) the provision of a blood or blood serum sample in the retaining device for the measuring sample, which has already been mixed with at least one heparin antagonist and/or which, when present in the retaining device, is mixed with at least one heparin antagonist in order to form an antagonist/heparin complex, c) in particular successive radiation of the measuring sample with at least two radiation sources, comprising the radiation of a multiple wavelength or of a continuous spectrum, with ray bundles of essentially parallel rays, d) the detection of the radiation scattered at a particular angle on the measuring sample using a detector comprising a detector inlet, and e) the wavelength and angle-dependent evaluation of the detected signal intensities in an evaluation unit in order to determine the concentration of the antagonist/heparin complex present in the measuring sample.

公开(公告)号：US07920260B2

公开(公告)日：2011-04-05

申请号：US12278573

申请日：2007-02-02

Applicant: Werner Mäntele ,  Vitali Vogel ,  Oliver Klein ,  Lea Schröder

Inventor： Werner Mäntele ,  Vitali Vogel ,  Oliver Klein ,  Lea Schröder

IPC: G01N15/02 ,  G01N21/00

CPC classification number: G01N15/0205 ,  G01N21/51 ,  G01N21/532 ,  G01N2015/0038 ,  G01N2015/0065 ,  G01N2021/4711 ,  G01N2021/4742 ,  G01N2021/4769

Abstract: A measuring device determines the size, size distribution, and/or concentration of nanoscopic particles or hollow spaces in a measuring sample, the degree of opacity of such measuring samples, or the degree of roughness of surfaces by determining the wavelength and scattering angle dependent intensities of a measuring radiation scattered on a measuring sample. The measuring device comprises a retaining device for a measuring sample to be measured, a detector comprising at least one detector inlet, an evaluation unit, and at least two radiation sources that are respectively at a distance from each other and at a distance from the measuring sample. Via the radiation sources, a ray bundle can in each case be emitted in an essentially parallel beam in the direction of the measuring sample. The ray bundles directed onto the measuring sample are aligned or can be aligned in different angles onto the measuring sample.

Abstract translation: 测量装置通过确定波长和散射角相关强度来确定测量样品中的纳米级颗粒或中空空间的尺寸，尺寸分布和/或浓度，这些测量样品的不透明度或表面粗糙度 的测量辐射散射在测量样品上。 测量装置包括用于待测量的测量样品的保持装置，包括至少一个检测器入口，评估单元和至少两个辐射源的检测器，所述至少两个辐射源分别彼此距离并且距离测量 样品。 通过辐射源，射线束可以在每种情况下沿测量样品的方向以基本平行的光束发射。 被引导到测量样品上的射线束对准或可以以不同的角度对准到测量样品上。

公开(公告)号：US07812312B2

公开(公告)日：2010-10-12

申请号：US10510017

申请日：2003-04-03

Applicant: Werner Mäntele ,  Oliver Klein ,  Christian Zscherp ,  Andreas Barth ,  Hermann Von Lillienfeld-Toal ,  Hellmuth Von Prollius ,  Frithjof von Germar ,  Heribert Offermanns

Inventor： Werner Mäntele ,  Oliver Klein ,  Christian Zscherp ,  Andreas Barth ,  Hermann Von Lillienfeld-Toal ,  Hellmuth Von Prollius ,  Frithjof von Germar ,  Heribert Offermanns

IPC: G01J5/02

CPC classification number: G01N21/552 ,  G01J3/45 ,  G01J2003/425 ,  G01N21/3577 ,  G01N21/85

Abstract: The invention relates to an infrared measuring device, especially for the spectrometry of aqueous systems. Said device comprises at least one measuring unit, especially a measuring cell, also comprising at least one ATR-body and at least one infrared light source. The measuring unit contains at least one ATR-body which comprises at least two planar, substantially parallel limiting surfaces and which is transparent with respect to measuring radiation and which has an index of refraction which is greater than that of the medium which is arranged next to at least one limiting surface and which is to be examined, especially larger or equal to 1.5. The IR-measuring radiation on at least one of the planar, parallel limiting surfaces of the ATR-body can be totally reflected in an attenuated manner by at least six times.

Abstract translation: 本发明涉及一种红外测量装置，特别是用于水系统的光谱测定。 所述装置包括至少一个测量单元，特别是测量单元，还包括至少一个ATR体和至少一个红外光源。 测量单元包含至少一个ATR体，该ATR体包括至少两个平坦的基本上平行的限制表面，并且其相对于测量辐射是透明的，并且其具有大于被布置在邻近的介质的折射率 至少一个限制表面，并且要被检查，特别是大于或等于1.5。 在ATR体的至少一个平面平行限制表面上的IR测量辐射可以以衰减方式全部反射至少六次。