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公开(公告)号：US20110201780A1
公开(公告)日：2011-08-18
申请号：US13050848
申请日：2011-03-17
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译： 根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。 本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。 这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物 疾病
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公开(公告)号：US20090011501A1
公开(公告)日：2009-01-08
申请号：US12134169
申请日：2008-06-05
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译： 根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。 本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。 这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物 疾病
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公开(公告)号：US06965023B2
公开(公告)日：2005-11-15
申请号：US10001254
申请日：2001-11-15
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译： 根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。 本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。 这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物 疾病
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公开(公告)号：US20110123483A1
公开(公告)日：2011-05-26
申请号：US12943525
申请日：2010-11-10
申请人： Wilfried ROTH , Georg GDYNIA
发明人： Wilfried ROTH , Georg GDYNIA
IPC分类号： A61K38/19 , A61K31/7088 , A61K48/00 , A61K35/12 , A61P35/00
CPC分类号： A61K31/7088 , A61K38/00 , A61K45/06 , A61K48/00 , C07K14/4702 , A61K2300/00
摘要： The current invention relates to a method for treating a subject suffering from cancer comprising administering to said subject a therapeutically effective dose of High Mobility Group B1 (HMGB1) protein or of a polynucleotide comprising a coding region for an HMGB1 gene in an expressible form. Moreover, it relates to the combination of said method with other cancer treatment regimens.
摘要翻译： 本发明涉及用于治疗患有癌症的受试者的方法，包括向所述受试者施用治疗有效剂量的高迁移率组B1（HMGB1）蛋白或包含可表达形式的HMGB1基因的编码区的多核苷酸。 此外，它涉及所述方法与其他癌症治疗方案的组合。
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公开(公告)号：US20050192427A1
公开(公告)日：2005-09-01
申请号：US11090425
申请日：2005-03-25
申请人： John Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Lee , Wilfried Roth , Frank Stenner-Liewen
IPC分类号： C07K14/295 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/06
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译： 根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。 本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。 本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。 这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物 疾病
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