公开(公告)号：US20070264306A1

公开(公告)日：2007-11-15

申请号：US11745953

申请日：2007-05-08

申请人： Willem FLAMENG ,  Geofrey DE VISSCHER

发明人： Willem FLAMENG ,  Geofrey DE VISSCHER

IPC分类号： A61K38/48 ,  A61F2/00

CPC分类号： A61L27/3641 ,  A61L27/3625 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3843 ,  A61L27/50

摘要： The present invention relates to the use of matrices in cell recruitment and the to modified matrices comprising homing factors for in vivo recellularisation of implantable medical devices such as cardiac valves and vascular grafts.

摘要翻译： 本发明涉及基质在细胞募集中的用途，以及包含归位因子的修饰基质，用于可植入医疗装置如心脏瓣膜和血管移植物的体内补体化。

公开(公告)号：US08613777B2

公开(公告)日：2013-12-24

申请号：US12208879

申请日：2008-09-11

申请人： Thorsten Siess ,  Willem Flameng

发明人： Thorsten Siess ,  Willem Flameng

IPC分类号： A61F2/72

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2433 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/125

摘要： For the treatment of an insufficient cardiac valve or a cardiac valve with a stenosis, a device is provided that comprises a micro axial pump (40). The pump portion (14) of the micro axial pump carries a dilating device (18) suitable for pushing open a stenosis in a valve. The dilating device is designed as a high-pressure balloon. During dilation, the micro axial pump (40) operates so that the heart is relieved. With insufficient cardiac valves, a stent (21) is fastened to the dilating device (17), the stent surrounding a flexible cardiac valve prosthesis (20). By dilation, the stent (21) is pressed against the insufficient cardiac valve and the same is passivated. The cardiac valve of the cardiac valve prosthesis is unfolded to assume the function of the natural cardiac valve.

摘要翻译： 为了治疗心脏瓣膜不足或具有狭窄的心脏瓣膜，提供了包括微型轴向泵（40）的装置。 微型轴向泵的泵部分（14）承载适于推动打开瓣膜狭窄的扩张装置（18）。 扩张装置设计为高压气球。 在扩张期间，微型轴向泵（40）运行，使得心脏被释放。 在心脏瓣膜不足的情况下，将支架（21）紧固到扩张装置（17），支架围绕柔性心脏瓣膜假体（20）。 通过扩张，支架（21）被压在不足的心脏瓣膜上并且被钝化。 心脏瓣膜假体的心脏瓣膜展开以承担自然心脏瓣膜的功能。

公开(公告)号：US07390822B2

公开(公告)日：2008-06-24

申请号：US10492778

申请日：2002-10-10

申请人： Frans Eduard Janssens ,  Joseph Elisabeth Leenaerts ,  Francisco Javier Fernández-Gadea ,  Paul Joannes Ludovicus Herijgers ,  Theo Frans Meert ,  Antonio Gómez-Sánchez ,  Willem Flameng ,  Marcel J. M. Borgers

发明人： Frans Eduard Janssens ,  Joseph Elisabeth Leenaerts ,  Francisco Javier Fernández-Gadea ,  Paul Joannes Ludovicus Herijgers ,  Theo Frans Meert ,  Antonio Gómez-Sánchez ,  Willem Flameng ,  Marcel J. M. Borgers

IPC分类号： A61K31/445 ,  A61K31/454

CPC分类号： A61K31/454

摘要： The present invention relates to an agent for reducing ischaemic damage to an organ, in particular to a heart and a brain, pharmaceutical compositions comprising said agent and the use of said agent for the treatment of ischaemic diseases to the heart and the brain. The agent comprises a substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivative according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof, the N-oxide forms thereof and the prodrugs thereof. In particular are claimed the compounds according to Formula (I) in which A=B is C═O or SO2, X is a covalent bond, R1 is alkyloxy, alkyloxyalkyl, Ar or NR9R10, wherein R9 and R10 each independently are hydrogen or Ar; or A=B and R1 together form a benzoxazolyl radical; p is zero, R3 is benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and R4 and R5 each are hydrogen. The use of said agents has important clinical ramifications with regard to the reduction of ischaemic damage to an organ in a mammal, in particular to a heart and/or a brain, the prevention of coronary artery diseases in a mammal by inducing a cardioprotective effect and the treatment and prevention of stroke.

摘要翻译： 本发明涉及用于减轻对器官特别是心脏和脑的缺血性损伤的药剂，包含所述药物的药物组合物和所述药物用于治疗心脏和脑部的缺血性疾病的用途。 该试剂包含根据式（I）的取代的4-苯基-4- [1H-咪唑-2-基] - 哌啶衍生物，其药学上可接受的酸或碱加成盐，其立体化学异构形式，其互变异构形式， 其N-氧化物形式及其前药。 特别要求保护的是根据式（I）的化合物，其中A = B是CO或SO 2，X是共价键，R 1是烷氧基，烷氧基烷基， Ar或NR 9 R 10，其中R 9和R 10各自独立地为氢或Ar; 或A = B和R 1一起形成苯并恶唑基; p为0，R 3为任选被羟基，烷基或烷氧基羰基取代的苄基，R 4和R 5各自为氢。 所述试剂的使用对于减少对哺乳动物，特别是心脏和/或脑的器官的缺血损伤，通过诱导心脏保护作用来预防哺乳动物的冠状动脉疾病，具有重要的临床后果，以及 治疗和预防中风。

公开(公告)号：US20090024212A1

公开(公告)日：2009-01-22

申请号：US12208879

申请日：2008-09-11

申请人： Thorsten Siess ,  Willem Flameng

发明人： Thorsten Siess ,  Willem Flameng

IPC分类号： A61F2/24 ,  A61M29/00 ,  A61F2/06 ,  A61N1/362

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2433 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/125

摘要： For the treatment of an insufficient cardiac valve or a cardiac valve with a stenosis, a device is provided that comprises a micro axial pump (40). The pump portion (14) of the micro axial pump carries a dilating device (18) suitable for pushing open a stenosis in a valve. The dilating device is designed as a high-pressure balloon. During dilation, the micro axial pump (40) operates so that the heart is relieved. With insufficient cardiac valves, a stent (21) is fastened to the dilating device (17), the stent surrounding a flexible cardiac valve prosthesis (20). By dilation, the stent (21) is pressed against the insufficient cardiac valve and the same is passivated. The cardiac valve of the cardiac valve prosthesis is unfolded to assume the function of the natural cardiac valve.

摘要翻译： 为了治疗心脏瓣膜不足或具有狭窄的心脏瓣膜，提供了包括微型轴向泵（40）的装置。 微型轴向泵的泵部分（14）承载适于推动打开瓣膜狭窄的扩张装置（18）。 扩张装置设计为高压气球。 在扩张期间，微型轴向泵（40）运行，使得心脏被释放。 在心脏瓣膜不足的情况下，将支架（21）紧固到扩张装置（17），支架围绕柔性心脏瓣膜假体（20）。 通过扩张，支架（21）被压在不足的心脏瓣膜上并且被钝化。 心脏瓣膜假体的心脏瓣膜展开以承担自然心脏瓣膜的功能。

公开(公告)号：US20050049696A1

公开(公告)日：2005-03-03

申请号：US10964066

申请日：2004-10-13

申请人： Thorsten Siess ,  Willem Flameng

发明人： Thorsten Siess ,  Willem Flameng

IPC分类号： A61F2/82 ,  A61F2/24 ,  A61M1/10 ,  A61M1/12 ,  A61M29/02

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2433 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1098 ,  A61M1/122 ,  A61M1/125

摘要： For the treatment of an insufficient cardiac valve or a cardiac valve with a stenosis, a device is provided that comprises a micro axial pump (40). The pump portion (14) of the micro axial pump carries a dilating device (18) suitable for pushing open a stenosis in a valve. The dilating device is designed as a high-pressure balloon. During dilation, the micro axial pump (40) operates so that the heart is relieved. With insufficient cardiac valves, a stent (21) is fastened to the dilating device (17), the stent surrounding a flexible cardiac valve prosthesis (20). By dilation, the stent (21) is pressed against the insufficient cardiac valve and the same is passivated. The cardiac valve of the cardiac valve prosthesis is unfolded to assume the function of the natural cardiac valve.

摘要翻译： 为了治疗心脏瓣膜不足或具有狭窄的心脏瓣膜，提供了包括微型轴向泵（40）的装置。 微型轴向泵的泵部分（14）承载适于推动打开瓣膜狭窄的扩张装置（18）。 扩张装置设计为高压气球。 在扩张期间，微型轴向泵（40）运行，使得心脏被释放。 在心脏瓣膜不足的情况下，将支架（21）紧固到扩张装置（17），支架围绕柔性心脏瓣膜假体（20）。 通过扩张，支架（21）被压在不足的心脏瓣膜上并且被钝化。 心脏瓣膜假体的心脏瓣膜展开以承担自然心脏瓣膜的功能。