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8 条记录 (耗时 0.032 秒)

    Recombinant antibodies specific for a growth factor receptor
    1.
    发明授权
    Recombinant antibodies specific for a growth factor receptor 失效
    对生长因子受体特异的重组抗体

    公开(公告)号：US5571894A

    公开(公告)日：1996-11-05

    申请号：US235838

    申请日：1994-04-29

    申请人： Winfried S. Wels ,  Nancy E. Hynes ,  Ina-Maria Harweth ,  Bernd Groner ,  Norman Hardman ,  Markus Zwickl

    发明人： Winfried S. Wels ,  Nancy E. Hynes ,  Ina-Maria Harweth ,  Bernd Groner ,  Norman Hardman ,  Markus Zwickl

    IPC分类号： A61K38/00 ,  C07K16/32 ,  C07K16/28 ,  C07K16/46 ,  C12N15/62

    CPC分类号： C07K16/32 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/00

    摘要： The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacturing those recombinant and monoclonal antibodies, hybridoma cells secreting those monoclonal antibodies, a method of manufacturing those hybridoma cells, DNAs encoding the heavy and light chain variable domains and the recombinant antibody, a method of manufacturing that DNA, hybrid vectors suitable for the expression of that DNA, host cells transformed with that DNA, and processes of using those recombinant and monoclonal antibodies in the diagnosis and treatment of tumors.

    摘要翻译： 本发明涉及针对人生长因子受体c-erbB-2细胞外结构域的重组抗体，其包含轻链可变结构域和单克隆抗体的重链可变区，针对c-erbB-2本身的单克隆抗体， 制备这些重组和单克隆抗体的方法，分泌这些单克隆抗体的杂交瘤细胞，制备这些杂交瘤细胞的方法，编码重链和轻链可变区的DNA和重组抗体，制备该DNA的方法，适用于 该DNA的表达，用该DNA转化的宿主细胞，以及使用这些重组和单克隆抗体进行肿瘤诊断和治疗的过程。

    Recombinant antibodies specific for a growth factor receptor
    2.
    发明授权
    Recombinant antibodies specific for a growth factor receptor 失效
    对生长因子受体特异的重组抗体

    公开(公告)号：US5939531A

    公开(公告)日：1999-08-17

    申请号：US465473

    申请日：1995-06-05

    申请人： Winfried Stephan Wels ,  Nancy E. Hynes ,  Ina-Maria Harwerth ,  Bernd Groner ,  Norman Hardman ,  Markus Zwickl

    发明人： Winfried Stephan Wels ,  Nancy E. Hynes ,  Ina-Maria Harwerth ,  Bernd Groner ,  Norman Hardman ,  Markus Zwickl

    IPC分类号： A61K38/00 ,  C07K16/32 ,  C07K16/30 ,  C07K16/46

    CPC分类号： C07K16/32 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/00

    摘要： The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.

    摘要翻译： 本发明涉及针对人生长因子受体c-erbB-2细胞外结构域的重组抗体，其包含轻链可变结构域和单克隆抗体的重链可变区，针对c-erbB-2本身的单克隆抗体， 所述重组抗体和所述单克隆抗体的制备方法，分泌所述单克隆抗体的杂交瘤细胞，所述杂交瘤细胞的制备方法，编码轻链可变结构域的DNA，重链可变结构域和重组抗体的编码方法 所述DNA的制备方法，适于表达所述DNA的杂交载体，用所述DNA转化的宿主细胞，以及所述重组抗体和所述单克隆抗体在诊断和治疗肿瘤中的用途。

    Chimeric antibodies
    3.
    发明授权
    Chimeric antibodies 失效
    嵌合抗体

    公开(公告)号：US6020153A

    公开(公告)日：2000-02-01

    申请号：US307087

    申请日：1994-09-16

    申请人： Norman Hardman ,  Laura Lee Gill ,  Ronald F. J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

    发明人： Norman Hardman ,  Laura Lee Gill ,  Ronald F. J. de Winter ,  Kathrin Wagner ,  Christoph Heusser

    IPC分类号： C07K16/30 ,  C07K16/46 ,  C12P21/08 ,  G01N33/574 ,  C12N15/00 ,  C07H21/04 ,  C12N5/00 ,  C12P21/06 ,  C12D21/08

    CPC分类号： C07K16/3007 ,  C07K16/462 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/33

    摘要： The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.

    摘要翻译： 本发明涉及对人癌胚抗原（CEA）具有高特异性和亲和力的鼠/人嵌合单克隆抗体，其衍生物，制备这些抗体及其衍生物的方法，编码这些抗体重链和轻链的DNA，过程 用于制备所述DNA，产生和分泌抗体的哺乳动物细胞系和用于制备所述细胞系的方法。 嵌合抗体及其衍生物在体外和体内用于临床目的，特别是用于诊断癌症，用于肿瘤的定位和体内成像，用于治疗，例如癌症。 细胞毒素的定点递送和类似目的。 本发明还涉及含有所述嵌合单克隆抗体和/或其衍生物的测试试剂盒和药物组合物。