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27 条记录 (耗时 0.024 秒)

    Detection and Treatment of Pregnancy Complications Comprising Determining Sialyl Lewis Antigens and Administering hCG
    1.
    发明申请
    Detection and Treatment of Pregnancy Complications Comprising Determining Sialyl Lewis Antigens and Administering hCG 审中-公开

    公开(公告)号：US20200166527A1

    公开(公告)日：2020-05-28

    申请号：US16777444

    申请日：2020-01-30

    申请人： Women & Infants Hospital of Rhode Island

    发明人： Surendra Sharma ,  Satyan Kalkunte ,  Udo Jeschke

    IPC分类号： G01N33/76 ,  A61K38/24 ,  G01N33/68

    摘要： Disclosed herein is a method of identifying and/or addressing incipient preeclampsia in a patient-subject by the steps of (a) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a said patient-subject at about 25 weeks of pregnancy or earlier; (b) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a pregnant non-preeclampsia one or more subjects at about 30 weeks of pregnancy or later, wherein said at least one sialyl Lewis antigen assay is for a sialyl Lewis antigen assayed in step (a) is and if more than one subject is assayed, averaging said results; and (c) managing said patient-subject for preeclampsia, if said level of at least one sialyl Lewis antigen of step (a) is at or greater than about 20% above the level of such silalyl Lewis antigen assayed in step (b).

    Treatment of disease using inter-alpha inhibitor proteins
    3.
    发明授权
    Treatment of disease using inter-alpha inhibitor proteins 有权
    使用α间期抑制蛋白治疗疾病

    公开(公告)号：US09572872B2

    公开(公告)日：2017-02-21

    申请号：US14426832

    申请日：2013-09-09

    申请人： ProThera Biologics, Inc. ,  Women & Infants Hospital of Rhode Island

    发明人： Yow-Pin Lim ,  Barbara Stonestreet

    IPC分类号： A61K38/00 ,  A61K38/57

    CPC分类号： A61K38/57 ,  Y02A50/385 ,  Y02A50/393

    摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

    摘要翻译： 本发明涉及治疗哺乳动物（例如人）中的医学病症（例如疾病和损伤）的方法，例如缺氧/缺血，烧伤和病毒感染（例如，流感，西尼罗病毒和登革热 ），在成人和儿童（如新生儿）中，通过施用包含IAIP的组合物。

    TREATMENT OF DISEASE USING INTER-ALPHA INHIBITOR PROTEINS
    6.
    发明申请
    TREATMENT OF DISEASE USING INTER-ALPHA INHIBITOR PROTEINS 有权
    用ALPHA抑制蛋白治疗疾病

    公开(公告)号：US20150238578A1

    公开(公告)日：2015-08-27

    申请号：US14426832

    申请日：2013-09-09

    申请人： PROTHERA BIOLOGICS, INC. ,  WOMEN & INFANTS HOSPITAL OF RHODE ISLAND

    发明人： Yow-Pin Lim ,  Barbara Stonestreet

    IPC分类号： A61K38/57

    CPC分类号： A61K38/57 ,  Y02A50/385 ,  Y02A50/393

    摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

    摘要翻译： 本发明涉及治疗哺乳动物（例如人）中的医学病症（例如疾病和损伤）的方法，例如缺氧/缺血，烧伤和病毒感染（例如，流感，西尼罗河病毒和登革热 ），在成人和儿童（如新生儿）中，通过施用包含IAIP的组合物。

    Detection and Treatment of Pregnancy Complications
    8.
    发明申请
    Detection and Treatment of Pregnancy Complications 审中-公开

    公开(公告)号：US20180321262A1

    公开(公告)日：2018-11-08

    申请号：US15889261

    申请日：2018-02-06

    申请人： Women & Infants Hospital of Rhode Island

    发明人： Surendra Sharma ,  Satyan Kalkunte ,  Udo Jeschke

    IPC分类号： G01N33/76 ,  A61K38/24 ,  G01N33/68

    CPC分类号： G01N33/76 ,  A61K38/24 ,  G01N33/689 ,  G01N2400/10 ,  G01N2440/38 ,  G01N2800/368

    摘要： Disclosed herein is a method of identifying and/or addressing incipient preeclampsia in a patient-subject by the steps of (a) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a said patient-subject at about 25 weeks of pregnancy or earlier; (b) performing a bioassay to determine the level of at least one sialyl Lewis antigen in a pregnant non-preeclampsia one or more subjects at about 30 weeks of pregnancy or later, wherein said at least one sialyl Lewis antigen assay is for a sialyl Lewis antigen assayed in step (a) is and if more than one subject is assayed, averaging said results; and (c) managing said patient-subject for preeclampsia, if said level of at least one sialyl Lewis antigen of step (a) is at or greater than about 20% above the level of such silalyl Lewis antigen assayed in step (b).

    METHOD FOR THE DETECTION AND TREATMENT OF PROTEINOPATHIES
    10.
    发明公开
    METHOD FOR THE DETECTION AND TREATMENT OF PROTEINOPATHIES 审中-公开

    公开(公告)号：US20240077500A1

    公开(公告)日：2024-03-07

    申请号：US18260661

    申请日：2022-01-13

    申请人： Women & Infants Hospital of Rhode Island

    发明人： Surendra Sharma

    IPC分类号： G01N33/68 ,  G01N33/50

    CPC分类号： G01N33/6896 ,  G01N33/5091 ,  C12N2503/00 ,  G01N2333/4709 ,  G01N2800/28

    摘要： The present disclosure relates in part to a blood-based method for the detection of a proteinopathy in a subject including, but not limited to, Alzheimer's disease (AD), mild cognitive impairment (MCI), and preeclampsia (PE), utilizing autophagy-deficient trophoblast (ADT) cells to sequester protein aggregates from the serum of said subject, and permit detection thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a proteinopathy in a subject by the administration of trehalose, a salt, solvate, stereoisomer, derivative, prodrug and or any mixture thereof.