公开(公告)号：US09572872B2

公开(公告)日：2017-02-21

申请号：US14426832

申请日：2013-09-09

申请人： ProThera Biologics, Inc. ,  Women & Infants Hospital of Rhode Island

发明人： Yow-Pin Lim ,  Barbara Stonestreet

IPC分类号： A61K38/00 ,  A61K38/57

CPC分类号： A61K38/57 ,  Y02A50/385 ,  Y02A50/393

摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

摘要翻译： 本发明涉及治疗哺乳动物（例如人）中的医学病症（例如疾病和损伤）的方法，例如缺氧/缺血，烧伤和病毒感染（例如，流感，西尼罗病毒和登革热 ），在成人和儿童（如新生儿）中，通过施用包含IAIP的组合物。

公开(公告)号：US20150238578A1

公开(公告)日：2015-08-27

申请号：US14426832

申请日：2013-09-09

申请人： PROTHERA BIOLOGICS, INC. ,  WOMEN & INFANTS HOSPITAL OF RHODE ISLAND

发明人： Yow-Pin Lim ,  Barbara Stonestreet

IPC分类号： A61K38/57

CPC分类号： A61K38/57 ,  Y02A50/385 ,  Y02A50/393

摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

摘要翻译： 本发明涉及治疗哺乳动物（例如人）中的医学病症（例如疾病和损伤）的方法，例如缺氧/缺血，烧伤和病毒感染（例如，流感，西尼罗河病毒和登革热 ），在成人和儿童（如新生儿）中，通过施用包含IAIP的组合物。

公开(公告)号：US10258675B2

公开(公告)日：2019-04-16

申请号：US15407805

申请日：2017-01-17

申请人： ProThera Biologics, Inc. ,  Women & Infants Hospital of Rhode Island

发明人： Yow-Pin Lim ,  Barbara Stonestreet

IPC分类号： A61K38/57

摘要： The invention relates to methods of treatment of medical conditions (e.g., diseases and injuries) in a mammal (e.g., a human), such as hypoxia/ischemia, burns, and viral infections (e.g., influenza, West Nile virus, and Dengue fever), in adults and in children (e.g., neonates) by administering a composition that includes an IAIP.

公开(公告)号：US20210393750A1

公开(公告)日：2021-12-23

申请号：US17287952

申请日：2019-10-24

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Denice Spero ,  Andre Richard Santoso

IPC分类号： A61K38/57 ,  A61K45/06 ,  A61K9/00 ,  A61P31/12 ,  A61P11/00 ,  A61P1/00 ,  A61P37/06 ,  G01N33/68 ,  C07K14/81 ,  A23L33/17 ,  A23L33/19 ,  A23L2/66 ,  A23C9/152 ,  A23L33/00

摘要： Featured are a foodstuff containing an inter-alpha inhibitor protein (lαlp) (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof), methods of preparing a food-stuff containing an lαlp, and methods of treating and/or reducing the likelihood of developing a disease or condition (e.g., a disease or condition characterized by inflammation and/or low levels of an lαlp) in a subject in need thereof by administering a composition or a foodstuff containing an lαlp. Also featured are methods of purifying an lλlp (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof) from milk.

公开(公告)号：US20220099684A1

公开(公告)日：2022-03-31

申请号：US17404841

申请日：2021-08-17

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Denice Spero

IPC分类号： G01N33/68 ,  A61K38/57 ,  A61K45/06

摘要： Described herein are methods for quantifying IAIP levels in a sample.

公开(公告)号：US20230190894A1

公开(公告)日：2023-06-22

申请号：US17821713

申请日：2022-08-23

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Denice Spero ,  Richard Andrews

IPC分类号： A61K38/57 ,  A61P31/04 ,  A61P11/00 ,  A61K9/00 ,  C07K14/81 ,  A61K38/55

CPC分类号： A61K38/57 ,  A61P31/04 ,  A61P11/00 ,  A61K9/0019 ,  C07K14/811 ,  A61K38/55 ,  A61K45/06

摘要： The invention features methods for treating or preventing pulmonary diseases, including acute respiratory distress syndrome (ARDS) and pneumonia, in a subject in need thereof that involve administering to the subject inter-alpha inhibitor proteins (IαIps), including, e.g., inter-alpha inhibitor (IαI) and/or pre-alpha inhibitor (PαI).

公开(公告)号：US20230055086A1

公开(公告)日：2023-02-23

申请号：US17407063

申请日：2021-08-19

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Denice Spero

IPC分类号： G01N33/68 ,  G01N33/53

摘要： Described herein are methods for quantifying IAIP levels in a sample.

公开(公告)号：US09758570B2

公开(公告)日：2017-09-12

申请号：US14859705

申请日：2015-09-21

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Edward S. Sirya ,  Peter Brne

IPC分类号： A61K38/16 ,  A61K35/14 ,  C07K14/81 ,  A61K38/00

CPC分类号： A61K38/57 ,  A61K38/00 ,  C07K14/811

摘要： The present invention generally provides processes for purification of Inter-alpha inhibitor proteins (IαIp) and compositions thereof from blood.

公开(公告)号：US10076559B2

公开(公告)日：2018-09-18

申请号：US15439328

申请日：2017-02-22

申请人： ProThera Biologics, Inc.

发明人： Yow-Pin Lim ,  Edward S. Sirya ,  Peter Brne

IPC分类号： A61K39/395 ,  A61K38/00 ,  A61K38/57

CPC分类号： A61K38/57 ,  A61K38/00 ,  C07K14/811

摘要： The present invention generally provides processes for purification of Inter-alpha inhibitor proteins (IαIp) and compositions thereof from blood.