-
公开(公告)号：US20100255488A1
公开(公告)日：2010-10-07
申请号：US12749859
申请日：2010-03-30
申请人： Xiangxu Kong , Gene Shen
发明人： Xiangxu Kong , Gene Shen
CPC分类号： C12Q1/6818 , C07H19/207 , C12Q1/6869 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N2021/6441 , Y10T436/143333
摘要： FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
摘要翻译： 提供FRET标记的化合物用于分析反应。 在某些实施方案中，FRET标记的核苷酸类似物用于代替包含核酸的分析反应中天然存在的核苷三磷酸或其它类似物，例如模板指导的核酸合成，DNA测序，RNA测序，单碱基鉴定，杂交 ，结合测定和其他分析反应。
-
2.发明申请公开(公告)号：US20100136592A1
公开(公告)日：2010-06-03
申请号：US12622375
申请日：2009-11-19
申请人： Xiangxu Kong , Gene Shen , Andrei Fedorov , John Lyle , Grace Lee , Lubomir Sebo , Duc Do , Robert Weber , Stephen Dudek
发明人： Xiangxu Kong , Gene Shen , Andrei Fedorov , John Lyle , Grace Lee , Lubomir Sebo , Duc Do , Robert Weber , Stephen Dudek
IPC分类号： C12Q1/48 , C12N9/00 , C12N11/00 , C12N9/12 , C12Q1/00 , C07H19/04 , C12N9/96 , C12M1/34 , C09K15/08
CPC分类号： C07C49/255 , G01N21/6428 , G01N33/5306 , G01N2021/6432
摘要： Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
摘要翻译： 用于通过向反应混合物中加入一种或多种光诱导的损伤缓解剂来减少和/或防止一种或多种反应物在照明分析反应中的光诱导损伤的组合物，装置，系统和方法，并允许反应进行 这个时间小于光致伤害阈值期。
-
公开(公告)号：US08927212B2
公开(公告)日：2015-01-06
申请号：US12749859
申请日：2010-03-30
申请人： Xiangxu Kong , Gene Shen
发明人： Xiangxu Kong , Gene Shen
CPC分类号： C12Q1/6818 , C07H19/207 , C12Q1/6869 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N2021/6441 , Y10T436/143333
摘要： FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
摘要翻译： 提供FRET标记的化合物用于分析反应。 在某些实施方案中，FRET标记的核苷酸类似物用于代替包含核酸的分析反应中天然存在的核苷三磷酸或其它类似物，例如模板指导的核酸合成，DNA测序，RNA测序，单碱基鉴定，杂交 ，结合测定和其他分析反应。
-
公开(公告)号：US08834847B2
公开(公告)日：2014-09-16
申请号：US13208151
申请日：2011-08-11
申请人： Stephen Yue , Robert Weber , Xiangxu Kong , Andrei Fedorov , John Lyle
发明人： Stephen Yue , Robert Weber , Xiangxu Kong , Andrei Fedorov , John Lyle
IPC分类号： A61B5/00 , C12Q1/68 , C12Q1/25 , G01N33/52 , G01N33/543
CPC分类号： C12Q1/6869 , C12N13/00 , C12Q1/25 , G01N33/52 , G01N33/54373 , G01N2333/91245 , G01N2333/916
摘要： Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
摘要翻译： 用于通过向反应混合物中加入一种或多种光保护性化合物并允许反应进行一段时间，以减少和/或防止照明分析反应中的一种或多种反应物的光诱导损伤的组合物，装置，系统和方法 小于光致伤害阈值期。
-
公开(公告)号：US08501922B2
公开(公告)日：2013-08-06
申请号：US12367411
申请日：2009-02-06
申请人： Geoffrey Otto , Gene Shen , Xiangxu Kong , Robin Emig
发明人： Geoffrey Otto , Gene Shen , Xiangxu Kong , Robin Emig
摘要： The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
-
公开(公告)号：US20130071849A1
公开(公告)日：2013-03-21
申请号：US13427611
申请日：2012-03-22
申请人： Xiangxu Kong , Gene Shen
发明人： Xiangxu Kong , Gene Shen
IPC分类号： G01N21/64
CPC分类号： C12Q1/6818 , C07H19/207 , C12Q1/6869 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N2021/6441 , Y10T436/143333
摘要： FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
摘要翻译： 提供FRET标记的化合物用于分析反应。 在某些实施方案中，FRET标记的核苷酸类似物用于代替包含核酸的分析反应中天然存在的核苷三磷酸或其它类似物，例如模板指导的核酸合成，DNA测序，RNA测序，单碱基鉴定，杂交 ，结合测定和其他分析反应。
-
公开(公告)号：US20090325260A1
公开(公告)日：2009-12-31
申请号：US12367411
申请日：2009-02-06
申请人： Geoffrey Otto , Gene Shen , Xiangxu Kong , Robin Emig
发明人： Geoffrey Otto , Gene Shen , Xiangxu Kong , Robin Emig
摘要： The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
摘要翻译： 本发明提供用于进行照明反应，特别是测序反应的方法和组合物，同时减轻和/或防止可能由长时间照射引起的反应物的光损伤。 特别地，本发明提供了将光保护剂掺入包含报告分子和核苷多磷酸酯的缀合物中的方法和组合物。
-
公开(公告)号：US09551660B2
公开(公告)日：2017-01-24
申请号：US13427611
申请日：2012-03-22
申请人： Xiangxu Kong , Gene Shen
发明人： Xiangxu Kong , Gene Shen
IPC分类号： C12Q1/68 , C07H19/04 , C07H21/04 , G01N21/64 , C07H19/207 , G01N33/542 , G01N33/58
CPC分类号： C12Q1/6818 , C07H19/207 , C12Q1/6869 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N2021/6441 , Y10T436/143333
摘要： FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
摘要翻译： 提供FRET标记的化合物用于分析反应。 在某些实施方案中，FRET标记的核苷酸类似物用于代替包含核酸的分析反应中天然存在的核苷三磷酸或其它类似物，例如模板指导的核酸合成，DNA测序，RNA测序，单碱基鉴定，杂交 ，结合测定和其他分析反应。
-
9.发明授权Photo-induced damage mitigating agents and preparation and methods of use thereof 有权光诱导的损伤缓解剂及其制备方法及其使用方法公开(公告)号：US08388982B2
公开(公告)日：2013-03-05
申请号：US12622375
申请日：2009-11-19
申请人： Xiangxu Kong , Gene Shen , Andrei Fedorov , John Lyle , Grace Lee , Lubomir Sebo , Duc Do , Robert Weber , Stephen Dudek
发明人： Xiangxu Kong , Gene Shen , Andrei Fedorov , John Lyle , Grace Lee , Lubomir Sebo , Duc Do , Robert Weber , Stephen Dudek
CPC分类号： C07C49/255 , G01N21/6428 , G01N33/5306 , G01N2021/6432
摘要： Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
摘要翻译： 用于通过向反应混合物中加入一种或多种光诱导的损伤缓解剂来减少和/或防止一种或多种反应物在照明分析反应中的光诱导损伤的组合物，装置，系统和方法，并允许反应进行 这个时间小于光致伤害阈值周期。
-
公开(公告)号：US20120052488A1
公开(公告)日：2012-03-01
申请号：US13208151
申请日：2011-08-11
申请人： Stephen Yue , Robert Weber , Xiangxu Kong , Andrei Fedorov , John Lyle
发明人： Stephen Yue , Robert Weber , Xiangxu Kong , Andrei Fedorov , John Lyle
IPC分类号： C12Q1/68 , C07D405/14 , C07C243/14 , C07C63/04 , C07C309/19
CPC分类号： C12Q1/6869 , C12N13/00 , C12Q1/25 , G01N33/52 , G01N33/54373 , G01N2333/91245 , G01N2333/916
摘要： Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
摘要翻译： 用于通过向反应混合物中加入一种或多种光保护性化合物并允许反应进行一段时间，以减少和/或防止照明分析反应中的一种或多种反应物的光诱导损伤的组合物，装置，系统和方法 小于光致伤害阈值期。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.015 秒)
