公开(公告)号：US20090036519A1

公开(公告)日：2009-02-05

申请号：US12233069

申请日：2008-09-18

申请人： Tatsumasa MAE ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa MAE ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A61K31/352 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient.The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

摘要翻译： 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

公开(公告)号：US20070129427A1

公开(公告)日：2007-06-07

申请号：US10580588

申请日：2003-11-25

申请人： Yutaka Sashida ,  Yoshihiro Mimaki ,  Minpei Kuroda ,  Ryosuke Kobayashi ,  Hiroaki Kando ,  Kosuke Nosaka ,  Hiroyasu Ishii ,  Takao Yamori

发明人： Yutaka Sashida ,  Yoshihiro Mimaki ,  Minpei Kuroda ,  Ryosuke Kobayashi ,  Hiroaki Kando ,  Kosuke Nosaka ,  Hiroyasu Ishii ,  Takao Yamori

IPC分类号： A61K31/365 ,  A61K31/353

CPC分类号： C07D307/935 ,  C07C45/80 ,  C07C49/743 ,  C07D311/30

摘要： There are provided novel compounds that have been extracted and isolated from a plant belonging to the family Compositae. Compounds represented by general formula (I): wherein R1 represents hydroxyl and R2 represents methoxy.

摘要翻译： 提供从属于菊科的植物提取和分离的新化合物。 由通式（I）表示的化合物：其中R 1表示羟基，R 2表示甲氧基。

公开(公告)号：US20050014819A1

公开(公告)日：2005-01-20

申请号：US10490641

申请日：2002-10-11

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A23K1/16 ,  A23K1/18 ,  A23L1/30 ,  A61K31/12 ,  A61K31/353 ,  A61K31/366 ,  A61K31/37 ,  A61K36/00 ,  A61K36/484 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P37/02 ,  A61P43/00 ,  C07D311/06 ,  C07D311/18 ,  C07D311/30 ,  C07D311/36 ,  C07D311/38 ,  C07D311/58 ,  C07D493/04

CPC分类号： C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenyl flavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

摘要翻译： 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯黄酮，不含异戊烯基类黄酮的查耳酮衍生物，不包含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或酯化物质 或食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

公开(公告)号：US20150037440A1

公开(公告)日：2015-02-05

申请号：US14517818

申请日：2014-10-18

申请人： KAZUE TAGUCHI ,  SHIGERU TAGUCHI ,  YUTAKA SASHIDA

发明人： KAZUE TAGUCHI ,  SHIGERU TAGUCHI ,  YUTAKA SASHIDA

IPC分类号： A61K36/752 ,  A23L2/52 ,  A23L1/30

CPC分类号： A61K36/752 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/75 ,  A23V2200/318 ,  A23V2250/21

摘要： The present invention provides a method for suppressing and relieving itching and inflammation, by administering to a host in need of such treatment an effective amount of the pharmaceutical composition containing highly lipophilic polyalkoxyflavonoid. The pharmaceutical composition and functional food of the present invention for suppressing and relieving itching and inflammation contain highly lipophilic polyalkoxyflavonoid extracted from squeezed juice of a whole portion of a citrus fruit (inclusive of pericarp thereof). Furthermore, the functional food of the present invention contains it.

摘要翻译： 本发明提供抑制和缓解瘙痒和炎症的方法，通过向需要这种治疗的宿主施用有效量的含有高度亲脂性的聚烷氧基黄酮酮的药物组合物。 用于抑制和缓解瘙痒和炎症的本发明的药物组合物和功能性食品包含从柑橘类水果的全部部分（包括其果皮）的榨汁中提取的高度亲脂性的聚烷氧基类黄酮。 此外，本发明的功能性食品含有它。

公开(公告)号：US20120141615A1

公开(公告)日：2012-06-07

申请号：US13371085

申请日：2012-02-10

申请人： Kazue TAGUCHI ,  Shigeru TAGUCHI ,  Yutaka SASHIDA

发明人： Kazue TAGUCHI ,  Shigeru TAGUCHI ,  Yutaka SASHIDA

IPC分类号： A61K36/752 ,  A61P17/04 ,  A61K31/353

CPC分类号： A61K36/752 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/75 ,  A23V2200/318 ,  A23V2250/21

摘要： The present invention provides a method for suppressing and relieving itching and inflammation, by administering to a host in need of such treatment an effective amount of the pharmaceutical composition containing highly lipophilic polyalkoxyflavonoid. The pharmaceutical composition and functional food of the present invention for suppressing and relieving itching and inflammation contain highly lipophilic polyalkoxyflavonoid extracted from squeezed juice of a whole portion of a citrus fruit (inclusive of pericarp thereof). Furthermore, the functional food of the present invention contains it.

摘要翻译： 本发明提供抑制和缓解瘙痒和炎症的方法，通过向需要这种治疗的宿主施用有效量的含有高度亲脂性的聚烷氧基黄酮酮的药物组合物。 用于抑制和缓解瘙痒和炎症的本发明的药物组合物和功能性食品包含从柑橘类水果的全部部分（包括其果皮）的榨汁中提取的高度亲脂性的聚烷氧基类黄酮。 此外，本发明的功能性食品含有它。

公开(公告)号：US07888388B2

公开(公告)日：2011-02-15

申请号：US12233069

申请日：2008-09-18

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A01N43/16

CPC分类号： C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient.The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

摘要翻译： 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

公开(公告)号：US07090874B2

公开(公告)日：2006-08-15

申请号：US10752643

申请日：2004-01-08

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A61K36/9066

CPC分类号： A61K31/12 ,  A21D2/14 ,  A23D7/0056 ,  A23D9/007 ,  A23K20/111 ,  A23K50/40 ,  A23L7/109 ,  A23L27/60 ,  A23L33/105 ,  A61K31/00

摘要： The object of the present invention is to provide PPARγ ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPARγ ligand as an active agent.The present invention relates to a ligand for peroxisome proliferator-activated receptor which comprises curcumin or its derivatives. The composition according to the present invention, which comprises the PPARγ ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

公开(公告)号：US20090304828A1

公开(公告)日：2009-12-10

申请号：US12224193

申请日：2007-02-19

申请人： Kazue Taguchi ,  Shigeru Taguchi ,  Yutaka Sashida

发明人： Kazue Taguchi ,  Shigeru Taguchi ,  Yutaka Sashida

IPC分类号： A61K36/752 ,  A61K31/35

CPC分类号： A61K36/752 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/75 ,  A23V2200/318 ,  A23V2250/21

摘要： It is intended to provide a drug and a functional food by which any itching such as common itching and intractable itching can be safely controlled and relieved and, furthermore, inflammation can be controlled and relieved. A medicine capable of controlling and relieving itching and inflammation which contains a highly lipophilic polyalkoxyflavonoid extracted from a press juice of a whole citrus fruit (a fruit having its peel), and a function food containing this medicine.

摘要翻译： 旨在提供一种药物和功能性食品，其中可以安全地控制和缓解诸如瘙痒和顽固性瘙痒的任何瘙痒，此外，可以控制和缓解炎症。 一种能够控制和缓解瘙痒和炎症的药物，其含有从整个柑橘类水果（具有其果皮的果实）的榨汁中提取的高度亲脂性的聚烷氧基黄酮，以及含有该药物的功能食品。

公开(公告)号：US08889198B2

公开(公告)日：2014-11-18

申请号：US13371085

申请日：2012-02-10

申请人： Kazue Taguchi ,  Shigeru Taguchi ,  Yutaka Sashida

发明人： Kazue Taguchi ,  Shigeru Taguchi ,  Yutaka Sashida

IPC分类号： A01N65/00 ,  A61K36/752 ,  A23L1/30 ,  A61K36/75 ,  A61K31/353

CPC分类号： A61K36/752 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/75 ,  A23V2200/318 ,  A23V2250/21

摘要： The present invention provides a method for suppressing and relieving itching and inflammation, by administering to a host in need of such treatment an effective amount of the pharmaceutical composition containing highly lipophilic polyalkoxyflavonoid. The pharmaceutical composition and functional food of the present invention for suppressing and relieving itching and inflammation contain highly lipophilic polyalkoxyflavonoid extracted from squeezed juice of a whole portion of a citrus fruit (inclusive of pericarp thereof). Furthermore, the functional food of the present invention contains it.

摘要翻译： 本发明提供抑制和缓解瘙痒和炎症的方法，通过向需要这种治疗的宿主施用有效量的含有高度亲脂性的聚烷氧基黄酮酮的药物组合物。 用于抑制和缓解瘙痒和炎症的本发明的药物组合物和功能性食品包含从柑橘类水果的全部部分（包括其果皮）的榨汁中提取的高度亲脂性的聚烷氧基类黄酮。 此外，本发明的功能性食品含有它。

公开(公告)号：US07524975B2

公开(公告)日：2009-04-28

申请号：US10490641

申请日：2002-10-11

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： C07D311/00

CPC分类号： C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

摘要翻译： 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。