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    METHOD FOR EVALUATING CELL AGING BY EXPRESSION LEVEL OF COFILIN
    2.
    发明申请
    METHOD FOR EVALUATING CELL AGING BY EXPRESSION LEVEL OF COFILIN 有权
    通过COFILIN表达水平评估细胞衰老的方法

    公开(公告)号：US20130004962A1

    公开(公告)日：2013-01-03

    申请号：US13175505

    申请日：2011-07-01

    Applicant: Yi-Jang Lee ,  Cheng-Han Tsai

    Inventor： Yi-Jang Lee ,  Cheng-Han Tsai

    IPC: G01N33/566 ,  C12N15/85 ,  C12N5/071 ,  C12Q1/02 ,  C12Q1/34

    CPC classification number: G01N33/6872 ,  G01N2800/7042

    Abstract: The present invention discloses a concept that the expression level of cofilin may reflect the senescent condition of a cell or tissue. According to the findings in present invention, a method for determining the cellular senescent condition in a cell or tissue sample by evaluating the expression level of cofilin is provided. The detection of the expression level of cofilin is also used to screen an effective compound or composition for regulating the senescent condition in target cells.

    Abstract translation: 本发明公开了一种概念，即cofilin的表达水平可以反映细胞或组织的衰老状态。 根据本发明的发现，提供了通过评价柯菲林的表达水平来测定细胞或组织样品中的细胞衰老状态的方法。 检测cofilin的表达水平也用于筛选有效的化合物或组合物，用于调节靶细胞中的衰老状况。

    Method for evaluating cell aging by expression level of cofilin
    3.
    发明授权
    Method for evaluating cell aging by expression level of cofilin 有权
    通过cofilin表达水平评估细胞衰老的方法

    公开(公告)号：US08574852B2

    公开(公告)日：2013-11-05

    申请号：US13175505

    申请日：2011-07-01

    Applicant: Yi-Jang Lee ,  Cheng-Han Tsai

    Inventor： Yi-Jang Lee ,  Cheng-Han Tsai

    IPC: G01N33/53

    CPC classification number: G01N33/6872 ,  G01N2800/7042

    Abstract: The present invention discloses a concept that the expression level of cofilin may reflect the senescent condition of a cell or tissue. According to the findings in present invention, a method for determining the cellular senescent condition in a cell or tissue sample by evaluating the expression level of cofilin is provided. The detection of the expression level of cofilin is also used to screen an effective compound or composition for regulating the senescent condition in target cells.

    Abstract translation: 本发明公开了一种概念，即cofilin的表达水平可以反映细胞或组织的衰老状态。 根据本发明的发现，提供了通过评价柯菲林的表达水平来测定细胞或组织样品中的细胞衰老状态的方法。 检测cofilin的表达水平也用于筛选有效的化合物或组合物，用于调节靶细胞中的衰老状况。

    SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO
    4.
    发明申请
    SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO 审中-公开
    在体外或体外对肿瘤进行肿瘤生长抑制评估的蛋白质的系统和方法

    公开(公告)号：US20110217239A1

    公开(公告)日：2011-09-08

    申请号：US12717143

    申请日：2010-03-04

    Applicant: Yi-Jang LEE ,  Cheng-Han TSAI ,  Liang-Ting LIN

    Inventor： Yi-Jang LEE ,  Cheng-Han TSAI ,  Liang-Ting LIN

    IPC: A61K49/00 ,  A61K31/7088 ,  C12N5/09 ,  C12N5/071 ,  A61P35/00

    CPC classification number: A61K31/7088 ,  A61K49/00

    Abstract: Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker. The present disclosure provides an expression composition for stably transforming cells, preferably tumor cells. The expression composition includes two vectors respectively include polynucleotides encoding a protein of interest and a visible marker, wherein each polynucleotide is operably linked to a tet-on system such that the protein of interest and the visible marker are co-expressed upon activation of the tet-on system. The present disclosure also provides stably transfected cell lines, which may be used to access real-time biological processes, including tumor cell proliferation.

    Abstract translation: 本文公开了用于在体内或体外通过共表达可见标记物追踪肿瘤同时评估肿瘤生长抑制的目的蛋白质的系统和方法。 本公开提供了用于稳定转化细胞，优选肿瘤细胞的表达组合物。 表达组合物包括两个载体，分别包括编码目的蛋白质和可见标记的多核苷酸，其中每个多核苷酸可操作地连接到tet-on系统，使得感兴趣的蛋白质和可见标记物在激活tet时共表达 - 系统。 本公开还提供了稳定转染的细胞系，其可用于接近实时生物过程，包括肿瘤细胞增殖。

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