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4 条记录 (耗时 0.016 秒)

    Methods for identifying analgesic agents
    1.
    发明申请
    Methods for identifying analgesic agents 有权
    镇痛剂鉴别方法

    公开(公告)号：US20070212685A1

    公开(公告)日：2007-09-13

    申请号：US10369909

    申请日：2003-02-19

    申请人： Marcia MacDonald ,  Mark Samuels ,  Robin Sherrington ,  Yigal Goldberg

    发明人： Marcia MacDonald ,  Mark Samuels ,  Robin Sherrington ,  Yigal Goldberg

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/6893 ,  C07H21/04 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6897

    摘要： The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.

    摘要翻译： 本发明涉及SCN9A中的突变引起人类先天性疼痛（CIP）的因素的发现。 本发明还涉及利用SCN9A基因及其表达产物的方法来筛选和鉴定对SCN9A有选择性的治疗剂，包括小的有机化合物，并且可用于治疗疼痛和其它疾病。 本发明还涉及使用这些化合物来治疗或改善这些病症的方法。

    Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof
    2.
    发明申请
    Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof 失效

    公开(公告)号：US20060073497A1

    公开(公告)日：2006-04-06

    申请号：US11197710

    申请日：2005-08-04

    申请人： Yigal Goldberg ,  Rajender Kamboj

    发明人： Yigal Goldberg ,  Rajender Kamboj

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/79

    CPC分类号： G01N33/5023 ,  A61K38/40 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5091 ,  G01N2500/10 ,  Y10T436/143333

    摘要： Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed, such fragments being of molecular weight of approximately 7 kDa to 43 kDa. Also disclosed are corresponding isolated polynucleotides encoding the fragments of the HFE2A protein. The invention includes derivatives and analogs of the polypeptide fragments of HFE2A, along with compositions of these, that are functionally active, i.e. capable of interacting with the HFE2A, as well as methods of production of the HFE2A cleavage products, derivatives and analogs, e.g. by recombinant means. Methods for identifying modulators of HFE2A, comprising contacting a test compound with HFE2A and determining a change in HFE2A activity due to the compound, are provided. Also taught are methods of diagnosing an animal afflicted with or at risk of developing a disease of iron metabolism comprising determining a change in the level, amount or activity of a fragment of an HFE2A obtained in a sample from said animal relative to the level, amount or activity of a fragment of an HFE2A obtained in a control sample from an unaffected animal, wherein a change identifies said individual as being affect by or at risk of developing a disease of iron metabolism. Methods for treating and/or preventing a disorder in animals comprising administering to an animal afflicted therewith, or at risk of developing said disorder, a therapeutically effective amount of an HFE2A modulator are provided.

    Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof
    3.
    发明授权
    Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof 有权
    少年血色素沉着病基因（HFE2A）裂解产物及其用途

    公开(公告)号：US08507435B2

    公开(公告)日：2013-08-13

    申请号：US13553321

    申请日：2012-07-19

    申请人： Yigal Goldberg ,  Rajender K. Kamboj

    发明人： Yigal Goldberg ,  Rajender K. Kamboj

    IPC分类号： A61K38/00

    CPC分类号： G01N33/5023 ,  A61K38/40 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5091 ,  G01N2500/10 ,  Y10T436/143333

    摘要： Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed. Also disclosed are corresponding isolated polynucleotides encoding the fragments of the HFE2A protein. Methods for identifying modulators of HFE2A, comprising contacting a test compound with HFE2A and determining a change in HFE2A activity due to the compound, are provided. Also taught are methods of diagnosing an animal afflicted with or at risk of developing a disease of iron metabolism. Methods for treating and/or preventing a disorder in animals comprising administering to an animal afflicted therewith, or at risk of developing said disorder, a therapeutically effective amount of an HFE2A modulator are provided.

    摘要翻译： 公开了能够结合和调节参与铁代谢途径的HFE2A和其它蛋白质（例如铁调素）的HFE2A蛋白质的分离片段。 还公开了编码HFE2A蛋白片段的相应的分离的多核苷酸。 用于鉴定HFE2A调节剂的方法，包括使测试化合物与HFE2A接触并确定由于该化合物引起的HFE2A活性的变化。 还教导了诊断患有或有发生铁代谢疾病风险的动物的方法。 用于治疗和/或预防动物疾病的方法包括向患有其的动物施用或处于发展所述病症的风险中，提供治疗有效量的HFE2A调节剂。