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    Hsan II related gene and expression products and uses thereof
    4.
    发明申请
    Hsan II related gene and expression products and uses thereof 审中-公开
    Hsan II相关基因及其表达产物及其用途

    公开(公告)号：US20060166207A1

    公开(公告)日：2006-07-27

    申请号：US10534419

    申请日：2003-11-12

    申请人： Ronald Lafreniere ,  Marie-Pierre Dube ,  Marcia MacDonald ,  Mark Samuels

    发明人： Ronald Lafreniere ,  Marie-Pierre Dube ,  Marcia MacDonald ,  Mark Samuels

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/6896

    摘要： Methods of utilizing a gene related to pain perception, herein dubbed HSN2, or its encoded protein, dubbed herein “sensorin,” for the screening and identification of agents for the treatment of pain, neuropathy and related disorders, especially small organic compounds, as well as methods of using these compounds to treat or otherwise ameliorate pain, neuropathy and related disorders in human patients. Novel polypeptides and polynucleotides, along with their nucleotide and amino acid sequences, are also disclosed.

    摘要翻译： 用于本文称为“感染蛋白”的HSN2或其编码的蛋白质，用于筛选和鉴定用于治疗疼痛，神经病和相关病症，特别是小有机化合物的药剂的疼痛感知相关基因的方法，以及 作为使用这些化合物治疗或改善人类患者的疼痛，神经病和相关疾病的方法。 还公开了新的多肽和多核苷酸及其核苷酸和氨基酸序列。

    Methods for identifying analgesic agents
    6.
    发明申请
    Methods for identifying analgesic agents 有权
    镇痛剂鉴别方法

    公开(公告)号：US20070212685A1

    公开(公告)日：2007-09-13

    申请号：US10369909

    申请日：2003-02-19

    申请人： Marcia MacDonald ,  Mark Samuels ,  Robin Sherrington ,  Yigal Goldberg

    发明人： Marcia MacDonald ,  Mark Samuels ,  Robin Sherrington ,  Yigal Goldberg

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/6893 ,  C07H21/04 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6897

    摘要： The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.

    摘要翻译： 本发明涉及SCN9A中的突变引起人类先天性疼痛（CIP）的因素的发现。 本发明还涉及利用SCN9A基因及其表达产物的方法来筛选和鉴定对SCN9A有选择性的治疗剂，包括小的有机化合物，并且可用于治疗疼痛和其它疾病。 本发明还涉及使用这些化合物来治疗或改善这些病症的方法。

    Vacuum device for substance extraction
    7.
    发明申请
    Vacuum device for substance extraction 有权
    物质提取真空装置

    公开(公告)号：US20050037483A1

    公开(公告)日：2005-02-17

    申请号：US10934229

    申请日：2004-09-03

    申请人： Danny Lincoln ,  Krishna Kumar ,  Mark Samuels

    发明人： Danny Lincoln ,  Krishna Kumar ,  Mark Samuels

    IPC分类号： F04B17/00 ,  F04B43/00 ,  F04B43/04 ,  F04B45/047 ,  C12M1/34 ,  F04B35/04

    CPC分类号： F04B45/047 ,  F04B17/00 ,  F04B43/0009 ,  F04B43/043

    摘要： A vacuum device and method for extraction of a substance from a fluid source, the vacuum device including an upper member that may be selectively, and operably, connected to a lower member. The upper member defines a bottom opening, and has a vacuum pump in fluid communication with the bottom opening. The vacuum pump is selectively coupled to an energy source. The lower member defines an inner cavity, a first opening, and a second opening, the inner cavity in communication with the first opening and the second opening. An elastic membrane defining an interior cavity is disposed in the inner cavity and is coupled to the first opening of the lower member. In use, the second opening of the lower member in placed in selective fluid communication with the fluid source, and the lower member is selectively coupled to the upper member such that the vacuum pump is electrically coupled to the energy source and the bottom opening of the upper member is in sealed contact with the first opening of the lower member so that the vacuum pump is in fluid communication with the interior cavity defined by the elastic membrane.

    摘要翻译： 一种用于从流体源提取物质的真空装置和方法，所述真空装置包括可以选择性地且可操作地连接到下部构件的上部构件。 上部构件限定底部开口，并且具有与底部开口流体连通的真空泵。 真空泵选择性地耦合到能量源。 下部构件限定内腔，第一开口和第二开口，内腔与第一开口和第二开口连通。 限定内腔的弹性膜设置在内腔中并且联接到下构件的第一开口。 在使用中，下部构件的第二开口放置成与流体源选择性地流体连通，并且下部构件选择性地联接到上部构件，使得真空泵电耦合到能量源和底部开口 上部构件与下部构件的第一开口密封接触，使得真空泵与由弹性膜限定的内部空腔流体连通。