公开(公告)号：US20050186286A1

公开(公告)日：2005-08-25

申请号：US10785090

申请日：2004-02-25

申请人： Yoshihiro Takami

发明人： Yoshihiro Takami

IPC分类号： A61K35/12 ,  A61K35/36 ,  A61L27/60 ,  C12N5/00 ,  C12P21/06

CPC分类号： A61K35/36 ,  A61L27/60 ,  C12N5/0068 ,  C12N2533/92

摘要： A method for decellularizing separated skin is provided, the method involving simultaneous treatment with a protease and a surfactant. A highly reliable acellular dermal matrix and an optimum allogeneic acellular dermal matrix for simultaneous grafting with an autologous skin graft are also provided. Furthermore, there is provided a method for producing an acellular dermal matrix, the method including a decellularizing step of treating separated skin simultaneously with a protease and a surfactant, and there is also provided a composite cultured skin employing as a substrate the acellular dermal matrix.

摘要翻译： 提供了分离皮肤脱细胞化的方法，该方法包括用蛋白酶和表面活性剂同时处理。 还提供了高度可靠的无细胞真皮基质和用于与自体皮肤移植同时移植的最佳同种异体脱细胞真皮基质。 此外，提供了一种生产无细胞真皮基质的方法，该方法包括与蛋白酶和表面活性剂同时处理分离的皮肤的脱细胞化步骤，并且还提供了使用无细胞真皮基质作为底物的复合培养皮肤。

公开(公告)号：US6126387A

公开(公告)日：2000-10-03

申请号：US147691

申请日：1999-05-05

申请人： Shigeru Yoshida ,  Yoshihiro Takami ,  Masaru Matsuda

发明人： Shigeru Yoshida ,  Yoshihiro Takami ,  Masaru Matsuda

IPC分类号： F04D5/00

CPC分类号： F04D5/002 ,  F04D5/007 ,  F05B2250/503 ,  F05B2260/96

摘要： A pump housing PH surrounding an impeller 21 comprises an inlet port 19 and an outlet port 20 disposed in a spaced-apart relationship from each other in a direction of rotation of the impeller 21, a pump passage 23 corresponding to vane grooves 22 of the impeller 21 and extending from the inlet port 19 to the outlet port 20 along the direction of the impeller rotation, and a partition 25 for partitioning between the outlet port 20 and the inlet port 19 along the direction of the impeller rotation. A passage-communicating portion 29 for communication between the inlet port 19 and the pump passage 23 is offset from the partition 25 in the direction of the impeller rotation, and a passage-enlarged portion 30 is provided between the partition 25 and the passage-communicating portion 29.

摘要翻译： PCT No.PCT / JP97 / 02915 Sec。 371日期1999年5月5日 102（e）日期1999年5月5日PCT提交1997年8月21日PCT公布。 第WO98 / 09082号公报 日期1998年3月5日围绕叶轮21的泵壳体PH包括沿叶轮21的旋转方向彼此间隔开地设置的入口端口19和出口端口20，对应于叶片的泵通道23 叶轮21的槽22并沿着叶轮旋转的方向从入口19延伸到出口20，以及用于沿着叶轮旋转方向在出口20和入口19之间分隔的隔板25。 用于在入口19和泵通道23之间连通的通道连通部分29沿着叶轮旋转方向从分隔件25偏移，并且通道扩大部分30设置在分隔件25与通道连通 部分29。

公开(公告)号：US06824366B2

公开(公告)日：2004-11-30

申请号：US10324853

申请日：2002-12-20

申请人： Kenzo Nagasaka ,  Yoshihiro Takami

发明人： Kenzo Nagasaka ,  Yoshihiro Takami

IPC分类号： F04B3504

CPC分类号： F02M37/08

摘要： A fuel pump in which a terminal plate can be liquid-tightly mounted to a body upper and prevented from being dislodged from the body upper without the need of other component parts is provided. The terminal plate is formed with a cut and raised portion for preventing dislodging. When the terminal plate is inserted into a terminal plate through-hole having a step portion, a projection and a press-fit portion, the cut and raised portion is closed by being pressed with the projection and allowed to reach the step portion without contacting the press-fit portion. Then, the cut and raised portion returns to its natural configuration. Thus, the terminal plate is prevented from being dislodged to fall into the fuel pump. Because the press-fit portion is not damaged when the terminal plate is inserted, the terminal plate can be placed in liquid-tight contact with the body upper block.

摘要翻译： 一种燃料泵，其中端子板可以液密地安装到主体上部并且防止其从主体上部移出而不需要其它部件。 端子板形成有用于防止脱落的切割和凸起部分。 当端子板插入到具有台阶部，突起部和压入部的端子板贯通孔中时，通过用突起部被按压而将切入部和凸起部封闭，并使其到达台阶部而不与 压合部分。 然后，切割和凸起部分返回其自然构造。 因此，能够防止端子板脱落而进入燃料泵。 由于当插入端子板时压配合部分不被损坏，所以端子板可以与主体上部块液密接触。

公开(公告)号：US06846155B2

公开(公告)日：2005-01-25

申请号：US10324852

申请日：2002-12-20

申请人： Yoshihiro Takami ,  Kenzo Nagasaka

发明人： Yoshihiro Takami ,  Kenzo Nagasaka

IPC分类号： F02M37/10 ,  F04D5/00 ,  F04D29/18 ,  F04D29/22

CPC分类号： F04D29/188

摘要： A fuel pump improved in pump efficiency is provided. An impeller rotating in a pump casing has an approximately disk-shaped configuration with a group of recesses formed in a region extending along the outer peripheries of the obverse and reverse sides of the impeller. The recesses are repeatedly arranged in the circumferential direction at a distance between each pair of adjacent recesses. The radially outer end face of each recess slantingly extends radially outward from a middle plane in the direction of thickness toward the obverse and reverse sides. With this fuel pump, the incidence of separation or vortex formation in the flow of fuel is minimized, and a high pump efficiency can be obtained.

摘要翻译： 提供了泵效率提高的燃料泵。 在泵壳体中旋转的叶轮具有大致圆盘形构造，在沿着叶轮的正反面的外周延伸的区域中形成有一组凹部。 凹部在圆周方向上以每对相邻凹部之间的距离重复地布置。 每个凹部的径向外端面从厚度方向上的中间平面向正反侧倾斜地向外延伸。 利用该燃料泵，燃料流中的分离或涡流形成的发生率被最小化，并且可以获得高泵效率。

公开(公告)号：US20070269791A1

公开(公告)日：2007-11-22

申请号：US10584630

申请日：2004-12-24

申请人： Yoshihiro Takami ,  Ryo Yamaguchi ,  Yasushi Matsuda

发明人： Yoshihiro Takami ,  Ryo Yamaguchi ,  Yasushi Matsuda

IPC分类号： A01N1/00

CPC分类号： A61L27/3683 ,  A61L27/362 ,  A61L27/60

摘要： An object of the present invention is to provide a method for producing an ADM suitable as a scaffold for a cultured skin, that is, a separation and decellularization method that enables various types of extracellular matrixes such as a basement membrane to be preserved, allows the epidermal layer to be peeled off easily, and does not cause any damage to the dermal matrix. The present invention relates to a skin separation and decellularization method comprising a step of freeze thawing harvested skin and then separating the skin into epidermis and dermis by a treatment with hypertonic saline, and a step of washing the separated dermis.

摘要翻译： 本发明的目的是提供一种适于作为培养皮肤的支架的ADM的制造方法，即能够保持各种类型的细胞外基质如基底膜的分离和脱细胞化方法， 表皮层容易剥离，并且不会对真皮基质造成任何损伤。 皮肤分离和脱细胞方法技术领域本发明涉及一种皮肤分离和脱细胞化方法，其包括冻融收获的皮肤，然后通过用高渗盐水处理将皮肤分离成表皮和真皮的步骤，以及洗涤分离的真皮的步骤。