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11 条记录 (耗时 0.018 秒)

    COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE
    6.
    发明申请
    COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
    用于治疗包含长效胰岛素结合剂和长效胰岛素诱导性糖尿病的糖尿病的组合物

    公开(公告)号：US20140120120A1

    公开(公告)日：2014-05-01

    申请号：US14123355

    申请日：2012-06-01

    申请人： Young Eun Woo ,  Myung Hyun Jang ,  Young Jin Park ,  Young Kyung Park ,  Chang Ki Lim ,  Se Chang Kwon

    发明人： Young Eun Woo ,  Myung Hyun Jang ,  Young Jin Park ,  Young Kyung Park ,  Chang Ki Lim ,  Se Chang Kwon

    IPC分类号： A61K47/48 ,  A61K38/26 ,  A61K38/28

    CPC分类号： A61K38/26 ,  A61K38/28 ,  A61K47/68 ,  A61K47/6811 ,  A61K47/6883

    摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.

    摘要翻译： 本发明涉及一种用于预防或治疗糖尿病的组合物，其包含长效胰岛素缀合物和长效促胰岛素肽缀合物，以及用于治疗糖尿病的治疗方法，更具体地说， 作用胰岛素结合物和长效促胰岛素肽结合物抑制胰岛素治疗引起的体重增加，以及由促胰岛素肽治疗引起的呕吐和恶心，并减少所需的胰岛素剂量，从而显着提高药物依从性。 此外，本发明的长效胰岛素缀合物和长效促胰岛素肽缀合物中的每一种都是通过非肽基连接体将胰岛素或促胰岛素肽与免疫球蛋白Fc区连接而制备的，从而显示出改善的体内持续时间 功效和稳定性。

    ILLUMINATION NORMALIZING METHOD AND APPARATUS
    7.
    发明申请
    ILLUMINATION NORMALIZING METHOD AND APPARATUS 有权
    照明正规化方法和装置

    公开(公告)号：US20090003726A1

    公开(公告)日：2009-01-01

    申请号：US12040170

    申请日：2008-02-29

    申请人： Young-Kyung Park ,  Seok-Lai Park ,  Ji-Hyoung Son ,  Kwang-Hee Jung ,  Joong-Kyu Kim

    发明人： Young-Kyung Park ,  Seok-Lai Park ,  Ji-Hyoung Son ,  Kwang-Hee Jung ,  Joong-Kyu Kim

    IPC分类号： G06K9/40

    CPC分类号： G06K9/00228 ,  G06K9/38

    摘要： An illumination normalizing apparatus and a method are disclosed. The illumination normalizing apparatus measures a discontinuity of each pixel of an input image, the discontinuity including a spatial gradient and a local inhomogeneity, produces a weight of each pixel from the discontinuity by using a transfer function, produces an estimated illumination by repeating a convolution operation on each weight, and subtracts the estimated illumination from the input image.

    摘要翻译： 公开了一种照明规范化装置和方法。 照明归一化装置测量输入图像的每个像素的不连续性，包括空间梯度和局部不均匀性的不连续性，通过使用传递函数从不连续性产生每个像素的权重，通过重复卷积运算产生估计的照明 并且从输入图像中减去估计的照明。